Genome Property Definition Page

AccessionGenProp0030
Nameglutathione biosynthesis
TypePATHWAY
DescriptionYES NO Glutathione (GSH) is gamma-Glu-Cys-Gly, a thiol whose -SH group is an important reductant in many systems. Some species use thiols other than glutathione: mycothione in Mycobacterium tuberculosis, gamma-glutamylcysteine in Halobacterium, trypanothione in trypanosomes. Cysteine and CoA may also serve. Glutathione biosynthesis is accomplished by two enzymes. First, glutamate--cysteine ligase links the gamma-COOH of Glu to the NH2 of Cys. Next, glutathione synthase creates a peptide bond from the COOH of Cys to the NH2 of Gly. Species that synthesize glutathione are likely to have a reductase for oxidized glutathione and a number of glutathione-dependent enzymes.
JCVI RoleGlutathione and analogs
Parent PropertyGenProp0184: cofactor biosynthesis
GenProp0196: sulfur metabolism
Web ReferencesKEGG: Glutathione Metabolism
Gene Ontology TermGO:0006750: glutathione biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
glutamate--cysteine ligaseGSH_1YESTIGR01434 (HMM): glutamate--cysteine ligase
TIGR01436 (HMM): glutamate--cysteine ligase
PF03074 (HMM): glutamate-cysteine ligase, catalytic subunit
TIGR02049 (HMM): glutamate--cysteine ligase
TIGR02048 (HMM): putative glutamate--cysteine ligase
TIGR01435 (HMM): glutamate--cysteine ligase/glutathione synthase
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
glutathione synthetaseGSH_2YESTIGR01380 (HMM): glutathione synthase
TIGR01986 (HMM): glutathione synthetase
TIGR01435 (HMM): glutamate--cysteine ligase/glutathione synthase
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis
GenProp0196sulfur metabolism


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis
GenProp0149sulfate reduction to sulfide, assimilatory
GenProp0155dissimilatory sulfate reduction
GenProp0161methionine biosynthesis from homoserine
GenProp0182reduction of oxidized methionine
GenProp0191sulfate/thiosulfate ABC transporter
GenProp0624sulfite reductase complex, Salmonella/Clostridium type
GenProp0654intracellular sulfur oxidation
GenProp0729methionine salvage from methylthioadenosine