Genome Property Definition Page

AccessionGenProp0030
Nameglutathione biosynthesis
TypePATHWAY
DescriptionYES NO Glutathione (GSH) is gamma-Glu-Cys-Gly, a thiol whose -SH group is an important reductant in many systems. Some species use thiols other than glutathione: mycothione in Mycobacterium tuberculosis, gamma-glutamylcysteine in Halobacterium, trypanothione in trypanosomes. Cysteine and CoA may also serve. Glutathione biosynthesis is accomplished by two enzymes. First, glutamate--cysteine ligase links the gamma-COOH of Glu to the NH2 of Cys. Next, glutathione synthase creates a peptide bond from the COOH of Cys to the NH2 of Gly. Species that synthesize glutathione are likely to have a reductase for oxidized glutathione and a number of glutathione-dependent enzymes.
JCVI RoleGlutathione and analogs
Parent PropertyGenProp0184: cofactor biosynthesis
GenProp0184: cofactor biosynthesis
GenProp0184: cofactor biosynthesis
GenProp0196: sulfur metabolism
GenProp0196: sulfur metabolism
GenProp0196: sulfur metabolism
Web ReferencesKEGG: Glutathione Metabolism
KEGG: Glutathione Metabolism
KEGG: Glutathione Metabolism
Gene Ontology TermGO:0006750: glutathione biosynthetic process (biological_process)
GO:0006750: glutathione biosynthetic process (biological_process)
GO:0006750: glutathione biosynthetic process (biological_process)
GO:0006750: glutathione biosynthetic process (biological_process)
GO:0006750: glutathione biosynthetic process (biological_process)
GO:0006750: glutathione biosynthetic process (biological_process)
GO:0006750: glutathione biosynthetic process (biological_process)
GO:0006750: glutathione biosynthetic process (biological_process)
GO:0006750: glutathione biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
glutamate--cysteine ligaseGSH_1YESTIGR01434 (HMM): glutamate--cysteine ligase
TIGR01436 (HMM): glutamate--cysteine ligase
PF03074 (HMM): glutamate-cysteine ligase, catalytic subunit
TIGR02049 (HMM): glutamate--cysteine ligase
TIGR02048 (HMM): putative glutamate--cysteine ligase
TIGR01435 (HMM): glutamate--cysteine ligase/glutathione synthase
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
glutamate--cysteine ligaseGSH_1YESTIGR01434 (HMM): glutamate--cysteine ligase
TIGR01436 (HMM): glutamate--cysteine ligase
PF03074 (HMM): glutamate-cysteine ligase, catalytic subunit
TIGR02049 (HMM): glutamate--cysteine ligase
TIGR02048 (HMM): putative glutamate--cysteine ligase
TIGR01435 (HMM): glutamate--cysteine ligase/glutathione synthase
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
glutamate--cysteine ligaseGSH_1YESTIGR01434 (HMM): glutamate--cysteine ligase
TIGR01436 (HMM): glutamate--cysteine ligase
PF03074 (HMM): glutamate-cysteine ligase, catalytic subunit
TIGR02049 (HMM): glutamate--cysteine ligase
TIGR02048 (HMM): putative glutamate--cysteine ligase
TIGR01435 (HMM): glutamate--cysteine ligase/glutathione synthase
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
glutathione synthetaseGSH_2YESTIGR01380 (HMM): glutathione synthase
TIGR01986 (HMM): glutathione synthetase
TIGR01435 (HMM): glutamate--cysteine ligase/glutathione synthase
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
glutathione synthetaseGSH_2YESTIGR01380 (HMM): glutathione synthase
TIGR01986 (HMM): glutathione synthetase
TIGR01435 (HMM): glutamate--cysteine ligase/glutathione synthase
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
glutathione synthetaseGSH_2YESTIGR01380 (HMM): glutathione synthase
TIGR01986 (HMM): glutathione synthetase
TIGR01435 (HMM): glutamate--cysteine ligase/glutathione synthase
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process
GO:0006750: glutathione biosynthetic process

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis
GenProp0184cofactor biosynthesis
GenProp0184cofactor biosynthesis
GenProp0196sulfur metabolism
GenProp0196sulfur metabolism
GenProp0196sulfur metabolism


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis
GenProp1096coenzyme B biosynthesis
GenProp0149sulfate reduction to sulfide, assimilatory
GenProp0155dissimilatory sulfate reduction
GenProp0161methionine biosynthesis from homoserine
GenProp0182reduction of oxidized methionine
GenProp0191sulfate/thiosulfate ABC transporter
GenProp0624sulfite reductase complex, Salmonella/Clostridium type
GenProp0654intracellular sulfur oxidation
GenProp0729methionine salvage from methylthioadenosine