Genome Property Definition Page

AccessionGenProp0036
Namebiotin biosynthesis
TypePATHWAY
DescriptionBiotin is an essential cofactor for many carboxylation (addition of C02) reactions. This property reflects biosynthesis from pimeloyl-CoA. The source of pimeloyl-CoA may vary. BioF (EC 2.3.1.47, 8-amino-7-oxononanoate synthase, also called 7-keto-8-aminopelargonic acid synthetase) converts pimeloyl-CoA to 8-amino-7-oxononanoate. BioA (EC 2.6.1.62, adenosylmethionine-8-amino-7-oxononanoate aminotransferase) converts the product to 7,8-diaminononanoate, from which BioD (EC 6.3.3.3, dethiobiotin synthase) makes dethiobiotin. BioB (EC 2.8.1.6, biotin synthase) then makes biotin itself. Enzymes such as BioH involved in pimeloyl-CoA biosynthesis typically receive biotin-related annotations but may also appear in genomes in which biotin is not synthesized and pimeloyl-CoA is used for something else.
JCVI RoleBiotin
Parent PropertyGenProp0184: cofactor biosynthesis
GenProp0196: sulfur metabolism
Web ReferencesKEGG: Biotin Metabolism
Gene Ontology TermGO:0006355: regulation of transcription, DNA-dependent (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0018065: protein-cofactor linkage (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
8-amino-7-oxononanoate synthase2YESTIGR00858 (HMM): 8-amino-7-oxononanoate synthaseGO:0009102: biotin biosynthetic process
adenosylmethionine-8-amino-7-oxononanoate aminotransferase3YESTIGR00508 (HMM): adenosylmethionine-8-amino-7-oxononanoate transaminaseGO:0009102: biotin biosynthetic process
dethiobiotin synthase4YESTIGR00347 (HMM): dethiobiotin synthaseGO:0009102: biotin biosynthetic process
biotin synthase5YESTIGR00433 (HMM): biotin synthaseGO:0009102: biotin biosynthetic process
BioCbioCNOTIGR02072 (HMM): malonyl-acyl carrier protein O-methyltransferase BioCGO:0009102: biotin biosynthetic process
bioH proteinbioHNOTIGR01738 (HMM): pimelyl-[acyl-carrier protein] methyl ester esteraseGO:0009102: biotin biosynthetic process
BioY family proteinbioYNOPF02632 (HMM): BioY familyGO:0009102: biotin biosynthetic process
biotin ligase domain proteinbirANOTIGR00121 (HMM): biotin--[acetyl-CoA-carboxylase] ligaseGO:0018065: protein-cofactor linkage
biotin repressorrepressoNOTIGR00122 (HMM): biotin operon repressorGO:0006355: regulation of transcription, DNA-dependent
GO:0009102: biotin biosynthetic process

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis
GenProp0196sulfur metabolism


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis
GenProp0149sulfate reduction to sulfide, assimilatory
GenProp0155dissimilatory sulfate reduction
GenProp0161methionine biosynthesis from homoserine
GenProp0182reduction of oxidized methionine
GenProp0191sulfate/thiosulfate ABC transporter
GenProp0624sulfite reductase complex, Salmonella/Clostridium type
GenProp0654intracellular sulfur oxidation
GenProp0729methionine salvage from methylthioadenosine