Genome Property Definition Page

AccessionGenProp0036
Namebiotin biosynthesis
TypePATHWAY
DescriptionBiotin is an essential cofactor for many carboxylation (addition of C02) reactions. This property reflects biosynthesis from pimeloyl-CoA. The source of pimeloyl-CoA may vary. BioF (EC 2.3.1.47, 8-amino-7-oxononanoate synthase, also called 7-keto-8-aminopelargonic acid synthetase) converts pimeloyl-CoA to 8-amino-7-oxononanoate. BioA (EC 2.6.1.62, adenosylmethionine-8-amino-7-oxononanoate aminotransferase) converts the product to 7,8-diaminononanoate, from which BioD (EC 6.3.3.3, dethiobiotin synthase) makes dethiobiotin. BioB (EC 2.8.1.6, biotin synthase) then makes biotin itself. Enzymes such as BioH involved in pimeloyl-CoA biosynthesis typically receive biotin-related annotations but may also appear in genomes in which biotin is not synthesized and pimeloyl-CoA is used for something else.
JCVI RoleBiotin
Parent PropertyGenProp0184: cofactor biosynthesis
GenProp0196: sulfur metabolism
GenProp0184: cofactor biosynthesis
GenProp0196: sulfur metabolism
GenProp0184: cofactor biosynthesis
GenProp0196: sulfur metabolism
Web ReferencesKEGG: Biotin Metabolism
KEGG: Biotin Metabolism
KEGG: Biotin Metabolism
Gene Ontology TermGO:0006355: regulation of transcription, DNA-dependent (biological_process)
GO:0006355: regulation of transcription, DNA-dependent (biological_process)
GO:0006355: regulation of transcription, DNA-dependent (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0018065: protein-cofactor linkage (biological_process)
GO:0018065: protein-cofactor linkage (biological_process)
GO:0018065: protein-cofactor linkage (biological_process)
GO:0006355: regulation of transcription, DNA-dependent (biological_process)
GO:0006355: regulation of transcription, DNA-dependent (biological_process)
GO:0006355: regulation of transcription, DNA-dependent (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0018065: protein-cofactor linkage (biological_process)
GO:0018065: protein-cofactor linkage (biological_process)
GO:0018065: protein-cofactor linkage (biological_process)
GO:0006355: regulation of transcription, DNA-dependent (biological_process)
GO:0006355: regulation of transcription, DNA-dependent (biological_process)
GO:0006355: regulation of transcription, DNA-dependent (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0009102: biotin biosynthetic process (biological_process)
GO:0018065: protein-cofactor linkage (biological_process)
GO:0018065: protein-cofactor linkage (biological_process)
GO:0018065: protein-cofactor linkage (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
8-amino-7-oxononanoate synthase2YESTIGR00858 (HMM): 8-amino-7-oxononanoate synthase
TIGR00858 (HMM): 8-amino-7-oxononanoate synthase
TIGR00858 (HMM): 8-amino-7-oxononanoate synthase
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
8-amino-7-oxononanoate synthase2YESTIGR00858 (HMM): 8-amino-7-oxononanoate synthase
TIGR00858 (HMM): 8-amino-7-oxononanoate synthase
TIGR00858 (HMM): 8-amino-7-oxononanoate synthase
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
8-amino-7-oxononanoate synthase2YESTIGR00858 (HMM): 8-amino-7-oxononanoate synthase
TIGR00858 (HMM): 8-amino-7-oxononanoate synthase
TIGR00858 (HMM): 8-amino-7-oxononanoate synthase
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
adenosylmethionine-8-amino-7-oxononanoate aminotransferase3YESTIGR00508 (HMM): adenosylmethionine-8-amino-7-oxononanoate transaminase
TIGR00508 (HMM): adenosylmethionine-8-amino-7-oxononanoate transaminase
TIGR00508 (HMM): adenosylmethionine-8-amino-7-oxononanoate transaminase
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
adenosylmethionine-8-amino-7-oxononanoate aminotransferase3YESTIGR00508 (HMM): adenosylmethionine-8-amino-7-oxononanoate transaminase
TIGR00508 (HMM): adenosylmethionine-8-amino-7-oxononanoate transaminase
TIGR00508 (HMM): adenosylmethionine-8-amino-7-oxononanoate transaminase
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
adenosylmethionine-8-amino-7-oxononanoate aminotransferase3YESTIGR00508 (HMM): adenosylmethionine-8-amino-7-oxononanoate transaminase
TIGR00508 (HMM): adenosylmethionine-8-amino-7-oxononanoate transaminase
TIGR00508 (HMM): adenosylmethionine-8-amino-7-oxononanoate transaminase
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
dethiobiotin synthase4YESTIGR00347 (HMM): dethiobiotin synthase
TIGR00347 (HMM): dethiobiotin synthase
TIGR00347 (HMM): dethiobiotin synthase
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
dethiobiotin synthase4YESTIGR00347 (HMM): dethiobiotin synthase
TIGR00347 (HMM): dethiobiotin synthase
TIGR00347 (HMM): dethiobiotin synthase
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
dethiobiotin synthase4YESTIGR00347 (HMM): dethiobiotin synthase
TIGR00347 (HMM): dethiobiotin synthase
TIGR00347 (HMM): dethiobiotin synthase
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
biotin synthase5YESTIGR00433 (HMM): biotin synthase
TIGR00433 (HMM): biotin synthase
TIGR00433 (HMM): biotin synthase
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
biotin synthase5YESTIGR00433 (HMM): biotin synthase
TIGR00433 (HMM): biotin synthase
TIGR00433 (HMM): biotin synthase
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
biotin synthase5YESTIGR00433 (HMM): biotin synthase
TIGR00433 (HMM): biotin synthase
TIGR00433 (HMM): biotin synthase
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
BioCbioCNOTIGR02072 (HMM): malonyl-acyl carrier protein O-methyltransferase BioC
TIGR02072 (HMM): malonyl-acyl carrier protein O-methyltransferase BioC
TIGR02072 (HMM): malonyl-acyl carrier protein O-methyltransferase BioC
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
BioCbioCNOTIGR02072 (HMM): malonyl-acyl carrier protein O-methyltransferase BioC
TIGR02072 (HMM): malonyl-acyl carrier protein O-methyltransferase BioC
TIGR02072 (HMM): malonyl-acyl carrier protein O-methyltransferase BioC
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
BioCbioCNOTIGR02072 (HMM): malonyl-acyl carrier protein O-methyltransferase BioC
TIGR02072 (HMM): malonyl-acyl carrier protein O-methyltransferase BioC
TIGR02072 (HMM): malonyl-acyl carrier protein O-methyltransferase BioC
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
bioH proteinbioHNOTIGR01738 (HMM): pimelyl-[acyl-carrier protein] methyl ester esterase
TIGR01738 (HMM): pimelyl-[acyl-carrier protein] methyl ester esterase
TIGR01738 (HMM): pimelyl-[acyl-carrier protein] methyl ester esterase
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
bioH proteinbioHNOTIGR01738 (HMM): pimelyl-[acyl-carrier protein] methyl ester esterase
TIGR01738 (HMM): pimelyl-[acyl-carrier protein] methyl ester esterase
TIGR01738 (HMM): pimelyl-[acyl-carrier protein] methyl ester esterase
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
bioH proteinbioHNOTIGR01738 (HMM): pimelyl-[acyl-carrier protein] methyl ester esterase
TIGR01738 (HMM): pimelyl-[acyl-carrier protein] methyl ester esterase
TIGR01738 (HMM): pimelyl-[acyl-carrier protein] methyl ester esterase
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
BioY family proteinbioYNOPF02632 (HMM): BioY family
PF02632 (HMM): BioY family
PF02632 (HMM): BioY family
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
BioY family proteinbioYNOPF02632 (HMM): BioY family
PF02632 (HMM): BioY family
PF02632 (HMM): BioY family
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
BioY family proteinbioYNOPF02632 (HMM): BioY family
PF02632 (HMM): BioY family
PF02632 (HMM): BioY family
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
GO:0009102: biotin biosynthetic process
biotin ligase domain proteinbirANOTIGR00121 (HMM): biotin--[acetyl-CoA-carboxylase] ligase
TIGR00121 (HMM): biotin--[acetyl-CoA-carboxylase] ligase
TIGR00121 (HMM): biotin--[acetyl-CoA-carboxylase] ligase
GO:0018065: protein-cofactor linkage
GO:0018065: protein-cofactor linkage
GO:0018065: protein-cofactor linkage
biotin ligase domain proteinbirANOTIGR00121 (HMM): biotin--[acetyl-CoA-carboxylase] ligase
TIGR00121 (HMM): biotin--[acetyl-CoA-carboxylase] ligase
TIGR00121 (HMM): biotin--[acetyl-CoA-carboxylase] ligase
GO:0018065: protein-cofactor linkage
GO:0018065: protein-cofactor linkage
GO:0018065: protein-cofactor linkage
biotin ligase domain proteinbirANOTIGR00121 (HMM): biotin--[acetyl-CoA-carboxylase] ligase
TIGR00121 (HMM): biotin--[acetyl-CoA-carboxylase] ligase
TIGR00121 (HMM): biotin--[acetyl-CoA-carboxylase] ligase
GO:0018065: protein-cofactor linkage
GO:0018065: protein-cofactor linkage
GO:0018065: protein-cofactor linkage
biotin repressorrepressoNOTIGR00122 (HMM): biotin operon repressor
TIGR00122 (HMM): biotin operon repressor
TIGR00122 (HMM): biotin operon repressor
GO:0006355: regulation of transcription, DNA-dependent
GO:0009102: biotin biosynthetic process
GO:0006355: regulation of transcription, DNA-dependent
GO:0009102: biotin biosynthetic process
GO:0006355: regulation of transcription, DNA-dependent
GO:0009102: biotin biosynthetic process
biotin repressorrepressoNOTIGR00122 (HMM): biotin operon repressor
TIGR00122 (HMM): biotin operon repressor
TIGR00122 (HMM): biotin operon repressor
GO:0006355: regulation of transcription, DNA-dependent
GO:0009102: biotin biosynthetic process
GO:0006355: regulation of transcription, DNA-dependent
GO:0009102: biotin biosynthetic process
GO:0006355: regulation of transcription, DNA-dependent
GO:0009102: biotin biosynthetic process
biotin repressorrepressoNOTIGR00122 (HMM): biotin operon repressor
TIGR00122 (HMM): biotin operon repressor
TIGR00122 (HMM): biotin operon repressor
GO:0006355: regulation of transcription, DNA-dependent
GO:0009102: biotin biosynthetic process
GO:0006355: regulation of transcription, DNA-dependent
GO:0009102: biotin biosynthetic process
GO:0006355: regulation of transcription, DNA-dependent
GO:0009102: biotin biosynthetic process

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis
GenProp0196sulfur metabolism
GenProp0184cofactor biosynthesis
GenProp0196sulfur metabolism
GenProp0184cofactor biosynthesis
GenProp0196sulfur metabolism


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis
GenProp1096coenzyme B biosynthesis
GenProp0149sulfate reduction to sulfide, assimilatory
GenProp0155dissimilatory sulfate reduction
GenProp0161methionine biosynthesis from homoserine
GenProp0182reduction of oxidized methionine
GenProp0191sulfate/thiosulfate ABC transporter
GenProp0624sulfite reductase complex, Salmonella/Clostridium type
GenProp0654intracellular sulfur oxidation
GenProp0729methionine salvage from methylthioadenosine