Genome Property Definition Page

AccessionGenProp0038
Nametetrahydrofolate biosynthesis from GTP and PABA
TypePATHWAY
DescriptionPolyglutamylated tetrahydrofolate is the central cofactor of one-carbon metabolism and is biosynthesized from GTP, para-aminobenzoate (from chorismate), and glutamate in a six step reaction.[1] The first enzyme, GTP cyclohydrolase I, in the biosynthesis of tetrahydrofolate in prokaryotes, of tetrahydrobiopterin in vertebrates, and of pteridine-containing pigments in insects catalizes dihydroneopterin triphosphate from GTP. This pathway is carried out by 6 enzymes, and the complete pathway is absent in animals.
JCVI RoleFolic acid
Parent PropertyGenProp0184: cofactor biosynthesis
Literature References
[ 1 ]Wang P, Wang Q, Aspinall TV, Sims PF, Hyde JE.  Transfection studies to explore essential folate metabolism and antifolate drug synergy in the human malaria parasite Plasmodium falciparum.  Mol Microbiol. 2004 Mar;51(5):1425-38.  PMID 14982635
Web ReferencesKEGG: Folate Biosynthesis
IUBMB: Folate Biosynthesis (early stages)
IUBMB: Folate Biosynthesis (late stages)
Gene Ontology TermGO:0046654: tetrahydrofolate biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
GTP cyclohydrolase I1NOTIGR00063 (HMM): GTP cyclohydrolase IGO:0046654: tetrahydrofolate biosynthetic process
dihydroneopterin aldolase2YESTIGR00525 (HMM): dihydroneopterin aldolaseGO:0046654: tetrahydrofolate biosynthetic process
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase3YESTIGR01498 (HMM): 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinaseGO:0046654: tetrahydrofolate biosynthetic process
dihydropteroate synthase4YESTIGR01496 (HMM): dihydropteroate synthaseGO:0046654: tetrahydrofolate biosynthetic process
dihydrofolate synthase5YESTIGR01499 (HMM): bifunctional protein FolCGO:0046654: tetrahydrofolate biosynthetic process
dihydrofolate reductase6YESPF00186 (HMM): dihydrofolate reductaseGO:0046654: tetrahydrofolate biosynthetic process

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis