Genome Property Definition Page

AccessionGenProp0047
NameIPP biosynthesis via mevalonate
TypePATHWAY
DescriptionIsoprenyl pyrophosphate (IPP) is synthesized in eukaryotes, archaea and certain bacteria by the mevalonate pathway (which is in contrast to the non-mevalonate pathway found more generally in prokaryotes). The bacteria containing this pathway are believed to have acquired it by lateral transfer, possible in more than one independent event [Wilding, et. al. (2000) J. Bacteriol. 182, 4319-4327]. Archaea are believed to possess a mevalonate pathway for production of IPP, but several of the steps are divergent from the known enzymes in eukaryotes and have not yet been conclusively identified [PMID: 11042147]. In eukaryotes this pathway is highly regulated to control the production of steroids which require IPP as a precursor. IPP is also required for the synthesis of menaquinone, ubiquinone, terpenoids, isoprene and prenylated proteins. The pathway begins with synthesis of (S)-3-hydroxy-3-methylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA by HMG-CoA synthase and contains 5 steps all of which are included as required elements for the assignment of the YES state for this property. Some organisms contain a pathway-specific acetoacetyl-CoA synthase which is included in the gene lists for this property but is not a required element for the determination of the property state. Other species likely obtain acetoacetyl-CoA from beta-oxidation of fatty acids or related processes.
JCVI RoleOther
Parent PropertyGenProp0046: IPP biosynthesis
GenProp0046: IPP biosynthesis
GenProp0046: IPP biosynthesis
Web ReferencesKEGG: Sterol biosynthesis
IUBMB: Mevalonate Biosynthesis
IUBMB: Terpenoid biosynthesis
KEGG: Sterol biosynthesis
IUBMB: Mevalonate Biosynthesis
IUBMB: Terpenoid biosynthesis
KEGG: Sterol biosynthesis
IUBMB: Mevalonate Biosynthesis
IUBMB: Terpenoid biosynthesis
Gene Ontology TermGO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway (biological_process)
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway (biological_process)
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway (biological_process)
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway (biological_process)
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway (biological_process)
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway (biological_process)
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway (biological_process)
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway (biological_process)
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
acetoacetyl-CoA synthase1NO2.3.1.9 (ECNUM)

TIGR01217 (HMM): acetoacetate-CoA ligase
acetoacetyl-CoA synthase1NO2.3.1.9 (ECNUM)

TIGR01217 (HMM): acetoacetate-CoA ligase
acetoacetyl-CoA synthase1NO2.3.1.9 (ECNUM)

TIGR01217 (HMM): acetoacetate-CoA ligase
hydroxymethylglutaryl-CoA synthase2YESTIGR01833 (HMM): hydroxymethylglutaryl-CoA synthase
TIGR01835 (HMM): hydroxymethylglutaryl-CoA synthase
TIGR00748 (HMM): putative hydroxymethylglutaryl-CoA synthase
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
hydroxymethylglutaryl-CoA synthase2YESTIGR01833 (HMM): hydroxymethylglutaryl-CoA synthase
TIGR01835 (HMM): hydroxymethylglutaryl-CoA synthase
TIGR00748 (HMM): putative hydroxymethylglutaryl-CoA synthase
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
hydroxymethylglutaryl-CoA synthase2YESTIGR01833 (HMM): hydroxymethylglutaryl-CoA synthase
TIGR01835 (HMM): hydroxymethylglutaryl-CoA synthase
TIGR00748 (HMM): putative hydroxymethylglutaryl-CoA synthase
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
hydroxymethylglutaryl-CoA reductase3YES1.1.1.34 (ECNUM)

1.1.1.88 (ECNUM)

TIGR00533 (HMM): hydroxymethylglutaryl-CoA reductase (NADPH)
TIGR00532 (HMM): hydroxymethylglutaryl-CoA reductase, degradative
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
hydroxymethylglutaryl-CoA reductase3YES1.1.1.34 (ECNUM)

1.1.1.88 (ECNUM)

TIGR00533 (HMM): hydroxymethylglutaryl-CoA reductase (NADPH)
TIGR00532 (HMM): hydroxymethylglutaryl-CoA reductase, degradative
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
hydroxymethylglutaryl-CoA reductase3YES1.1.1.34 (ECNUM)

1.1.1.88 (ECNUM)

TIGR00533 (HMM): hydroxymethylglutaryl-CoA reductase (NADPH)
TIGR00532 (HMM): hydroxymethylglutaryl-CoA reductase, degradative
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
mevalonate kinase4YESTIGR00549 (HMM): mevalonate kinaseGO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
mevalonate kinase4YESTIGR00549 (HMM): mevalonate kinaseGO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
mevalonate kinase4YESTIGR00549 (HMM): mevalonate kinaseGO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
phosphomevalonate kinase5YESTIGR01219 (HMM): phosphomevalonate kinase
TIGR01220 (HMM): phosphomevalonate kinase
TIGR01223 (HMM): phosphomevalonate kinase
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
phosphomevalonate kinase5YESTIGR01219 (HMM): phosphomevalonate kinase
TIGR01220 (HMM): phosphomevalonate kinase
TIGR01223 (HMM): phosphomevalonate kinase
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
phosphomevalonate kinase5YESTIGR01219 (HMM): phosphomevalonate kinase
TIGR01220 (HMM): phosphomevalonate kinase
TIGR01223 (HMM): phosphomevalonate kinase
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
diphosphomevalonate decarboxylase6YESTIGR01240 (HMM): diphosphomevalonate decarboxylaseGO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
diphosphomevalonate decarboxylase6YESTIGR01240 (HMM): diphosphomevalonate decarboxylaseGO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway
diphosphomevalonate decarboxylase6YESTIGR01240 (HMM): diphosphomevalonate decarboxylaseGO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway

Parent Properties
AccessionName
GenProp0046IPP biosynthesis
GenProp0046IPP biosynthesis
GenProp0046IPP biosynthesis


Sibling Properties
AccessionName
GenProp0048IPP biosynthesis via deoxyxylulose