Genome Property Definition Page

AccessionGenProp0048
NameIPP biosynthesis via deoxyxylulose
TypePATHWAY
DescriptionThe pathway for the biosynthesis of isoprenyl pyrophosphate (IPP) in most bacteria has been variously referred to as the non-mevalonate pathway (in contrast to the pathway found in eukaryotes), the glyceraldehyde-3-phosphate(GAP)-pyruvate pathway and the deoxyxylulose pathway. This pathway contains six characterized enzymes and may involve additional proteins as well.
JCVI RoleOther
Parent PropertyGenProp0046: IPP biosynthesis
GenProp0046: IPP biosynthesis
GenProp0046: IPP biosynthesis
Web ReferencesKEGG: Sterol biosynthesis
IUBMB: Non-Mevalonate Terpenoid biosynthesis
KEGG: Sterol biosynthesis
IUBMB: Non-Mevalonate Terpenoid biosynthesis
KEGG: Sterol biosynthesis
IUBMB: Non-Mevalonate Terpenoid biosynthesis
Gene Ontology TermGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway (biological_process)
GO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway (biological_process)
GO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway (biological_process)
GO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway (biological_process)
GO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway (biological_process)
GO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway (biological_process)
GO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway (biological_process)
GO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway (biological_process)
GO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
deoxyxylulose-5-phosphate synthase1YESTIGR00204 (HMM): 1-deoxy-D-xylulose-5-phosphate synthaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
deoxyxylulose-5-phosphate synthase1YESTIGR00204 (HMM): 1-deoxy-D-xylulose-5-phosphate synthaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
deoxyxylulose-5-phosphate synthase1YESTIGR00204 (HMM): 1-deoxy-D-xylulose-5-phosphate synthaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
1-deoxy-D-xylulose 5-phosphate reductoisomerase2YESTIGR00243 (HMM): 1-deoxy-D-xylulose 5-phosphate reductoisomeraseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
1-deoxy-D-xylulose 5-phosphate reductoisomerase2YESTIGR00243 (HMM): 1-deoxy-D-xylulose 5-phosphate reductoisomeraseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
1-deoxy-D-xylulose 5-phosphate reductoisomerase2YESTIGR00243 (HMM): 1-deoxy-D-xylulose 5-phosphate reductoisomeraseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseispDYESTIGR00453 (HMM): 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseispDYESTIGR00453 (HMM): 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseispDYESTIGR00453 (HMM): 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
4-diphosphocytidyl-2C-methyl-D-erythritol kinaseispEYESTIGR00154 (HMM): 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
4-diphosphocytidyl-2C-methyl-D-erythritol kinaseispEYESTIGR00154 (HMM): 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
4-diphosphocytidyl-2C-methyl-D-erythritol kinaseispEYESTIGR00154 (HMM): 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseispFYESTIGR00151 (HMM): 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseispFYESTIGR00151 (HMM): 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseispFYESTIGR00151 (HMM): 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthaseispGYESTIGR00612 (HMM): 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthaseispGYESTIGR00612 (HMM): 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthaseispGYESTIGR00612 (HMM): 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
4-hydroxy-3-methylbut-2-enyl diphosphate reductaseispHYESTIGR00216 (HMM): 4-hydroxy-3-methylbut-2-enyl diphosphate reductaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
4-hydroxy-3-methylbut-2-enyl diphosphate reductaseispHYESTIGR00216 (HMM): 4-hydroxy-3-methylbut-2-enyl diphosphate reductaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
4-hydroxy-3-methylbut-2-enyl diphosphate reductaseispHYESTIGR00216 (HMM): 4-hydroxy-3-methylbut-2-enyl diphosphate reductaseGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway

Parent Properties
AccessionName
GenProp0046IPP biosynthesis
GenProp0046IPP biosynthesis
GenProp0046IPP biosynthesis


Sibling Properties
AccessionName
GenProp0047IPP biosynthesis via mevalonate