Genome Property Definition Page

AccessionGenProp0052
Nametype III secretion
TypeSYSTEM
DescriptionType III secretion systems are found in a number of pathogenenic gram-negative bacteria. These systems consist of approximately twenty-five translocation proteins, as well as those proteins that are transported either across the bacterial inner and outer membrane, into the medium, or further across a eukaryotic target cell membrane. Substrates for type III secretion are not cleaved during transport, although the signal for transport appears to lie near the N-terminus (or in the RNA); chaperones act as well for some substrates and may be a second signal. Proteins delivered to the target cell cytosol and active in pathogenesis are termed effectors. Type III secretion systems resemble some of the flagellar export apparatus. In some cases, a type III pilus is observed and required for effector delivery. Gene nomeclature transposes across genomes: ysc in Yersinia, bsc in Bordetella, esc in enteropathogenic E. coli, hrc in plant pathogens, etc., so that Ysc, EscD, HrcD, etc. are homologous and functionally analogous [1,2].
Parent PropertyGenProp0074: virulence
GenProp0179: protein transport
Literature References
[ 1 ]Cornelis GR, Van Gijsegem F  Assembly and function of type III secretory systems.  Annu Rev Microbiol. 2000; 54: 735-74.  PMID 11018143
[ 2 ]Yap MN, Yang CH, Barak JD, Jahn CE, Charkowski AO  The Erwinia chrysanthemi type III secretion system is required for multicellular behavior.  J Bacteriol 2005 Jan;187(2):639-48.  PMID 15629935
[ 3 ]Pallen MJ, Beatson SA, Bailey CM  Bioinformatics, genomics and evolution of non-flagellar type-III secretion systems: a Darwinian perpective.  FEMS Microbiol Rev 2005 Apr;29(2):201-29.  PMID 15808742
Web ReferencesKEGG: Type III secretion system
Gene Ontology TermGO:0030254: protein secretion by the type III secretion system (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
HpaPHpaPNOTIGR02557 (HMM): type III secretion protein HpaPGO:0030254: protein secretion by the type III secretion system
HrpB1/HrpKHrpB1NOTIGR02561 (HMM): type III secretion protein HrpB1/HrpKGO:0030254: protein secretion by the type III secretion system
HrpB2HrpB2NOTIGR02558 (HMM): type III secretion protein HrpB2GO:0030254: protein secretion by the type III secretion system
HrpB4HrpB4NOTIGR02560 (HMM): type III secretion protein HrpB4GO:0030254: protein secretion by the type III secretion system
HrpB7HrpB7NOTIGR02559 (HMM): type III secretion protein HrpB7GO:0030254: protein secretion by the type III secretion system
LcrE/YopN/InvE/MxiCLcrENOTIGR02568 (HMM): type III secretion regulator YopN/LcrE/InvE/MxiCGO:0030254: protein secretion by the type III secretion system
LcrG/PcrGLcrGNOTIGR02573 (HMM): type III secretion protein LcrGGO:0030254: protein secretion by the type III secretion system
LcrH/SycD/SpaTLcrHNOTIGR02552 (HMM): type III secretion low calcium response chaperone LcrH/SycDGO:0030254: protein secretion by the type III secretion system
regulatory component LcrRLcrRNOTIGR02572 (HMM): type III secretion system regulator LcrRGO:0030254: protein secretion by the type III secretion system
OrgA/MxiKOrgANOTIGR02555 (HMM): type III secretion apparatus protein OrgA/MxiKGO:0030254: protein secretion by the type III secretion system
PrgHPrgHNOTIGR02554 (HMM): type III secretion apparatus protein PrgH/EprHGO:0030254: protein secretion by the type III secretion system
SpaK/InvB/YsaKSpaKNOPF03519 (HMM): invasion protein B familyGO:0030254: protein secretion by the type III secretion system
SseC/YopB/EspDSseCNOPF04888 (HMM): secretion system effector C, SseC-like familyGO:0030254: protein secretion by the type III secretion system
type III secretion chaperone SycHSycHNOPF05932 (HMM): type III secretion chaperone, CesT familyGO:0030254: protein secretion by the type III secretion system
type III secretion chaperone SycNSycNNOTIGR02503 (HMM): type III secretion chaperone SycNGO:0030254: protein secretion by the type III secretion system
type III secretion effector delivery regulator, TyeA familyTyeAYESTIGR02511 (HMM): type III secretion effector delivery regulator, TyeA familyGO:0030254: protein secretion by the type III secretion system
YopDYopDNOPF05844 (HMM): YopD proteinGO:0030254: protein secretion by the type III secretion system
needle length determinantndl_lenNOTIGR02514 (HMM): type III secretion system needle length determinantGO:0030254: protein secretion by the type III secretion system
type III secretion system needle proteinneedleYESTIGR02105 (HMM): type III secretion apparatus needle proteinGO:0030254: protein secretion by the type III secretion system
in operon: flanked by, co-oriented and tight with evidenceoperonNOOPERON (STR-CLUST)
Proximal regulatory componentsregulatoNOPF00165 (HMM-CLUST): transcriptional regulator, AraC family
PF00816 (HMM-CLUST): H-NS histone family
secretin, type III associatedsecretinNOPF03958 (HMM-CLUST): bacterial type II/III secretion system short domain proteinGO:0030254: protein secretion by the type III secretion system
Narrow clade specific componentsspecificNOGENE_CLUSTER (MANUAL)
GO:0030254: protein secretion by the type III secretion system
secreted proteins, effectorstargetNOPF03518 (HMM):
TIGR02101 (HMM): type III secretion target, IpaC/SipC family
TIGR02553 (HMM): type III effector protein IpaD/SipD/SspD
type III secretion system chaperone, YscB familyy_BNOTIGR02513 (HMM): type III secretion system chaperone, YscB familyGO:0030254: protein secretion by the type III secretion system
type III secretion outer membrane pore, YscC/HrcC familyy_C_h_CYESTIGR02516 (HMM): type III secretion outer membrane pore, YscC/HrcC familyGO:0030254: protein secretion by the type III secretion system
type III secretion apparatus protein, YscD/HrpQ familyy_D_h_QYESTIGR02500 (HMM): type III secretion apparatus protein, YscD/HrpQ familyGO:0030254: protein secretion by the type III secretion system
type III secretion system protein, YseE familyy_ENOTIGR02501 (HMM): type III secretion system protein, YseE familyGO:0030254: protein secretion by the type III secretion system
type III secretion protein, YscG familyy_GNOTIGR02508 (HMM): type III secretion protein, YscG familyGO:0030254: protein secretion by the type III secretion system
type III secretion protein YopR(YscH)y_HNOTIGR02509 (HMM): type III secretion effector, YopR familyGO:0030254: protein secretion by the type III secretion system
type III secretion apparatus protein, YscI/HrpBy_I_h_BYESTIGR02497 (HMM): type III secretion apparatus protein, YscI/HrpB, C-terminal domainGO:0030254: protein secretion by the type III secretion system
type III apparatus lipoprotein,y_J_h_JYESTIGR02544 (HMM): type III secretion apparatus lipoprotein, YscJ/HrcJ familyGO:0030254: protein secretion by the type III secretion system
YOP proteins translocation protein Ky_KNOPF06578 (HMM): YOP proteins translocation protein K (YscK)GO:0030254: protein secretion by the type III secretion system
type III secretion apparatus protein, HrpE/YscL familyy_L_h_EYESTIGR02499 (HMM): type III secretion apparatus protein, HrpE/YscL familyGO:0030254: protein secretion by the type III secretion system
type III secretion ATPasey_N_ATPYESTIGR02546 (HMM): type III secretion apparatus H+-transporting two-sector ATPaseGO:0030254: protein secretion by the type III secretion system
type III secretion protein YscOy_ONOPF07321 (HMM): type III secretion protein YscOGO:0030254: protein secretion by the type III secretion system
YscQ/HrcQ/SpaOy_Q_h_QYESTIGR02551 (HMM): type III secretion apparatus protein, YscQ/HrcQ familyGO:0030254: protein secretion by the type III secretion system
type III secretion apparatus protein, YscR/HrcR familyy_R_h_RYESTIGR01102 (HMM): type III secretion apparatus protein, YscR/HrcR familyGO:0030254: protein secretion by the type III secretion system
YscS/HrcS/SctS/EscSy_S_h_SYESTIGR01403 (HMM): type III secretion protein, HrpO familyGO:0030254: protein secretion by the type III secretion system
type III secretion protein, YscT/HrpX familyy_T_h_XYESTIGR01401 (HMM): type III secretion apparatus protein SpaR/YscT/HrcTGO:0030254: protein secretion by the type III secretion system
type III secretion protein, YscU/HrpY familyy_U_h_YYESTIGR01404 (HMM): type III secretion protein, YscU/HrpY familyGO:0030254: protein secretion by the type III secretion system
type III secretion protein, HrcVy_VYESTIGR01399 (HMM): type III secretion protein, HrcV familyGO:0030254: protein secretion by the type III secretion system
type III secretion chaperone YscWy_WNOTIGR02567 (HMM): type III secretion system chaperone YscWGO:0030254: protein secretion by the type III secretion system
type III secretion protein, YscX familyy_XNOTIGR02502 (HMM): type III secretion protein, YscX familyGO:0030254: protein secretion by the type III secretion system

Parent Properties
AccessionName
GenProp0074virulence
GenProp0179protein transport


Sibling Properties
AccessionName
GenProp0032pathogen of plants
GenProp0049spore formation
GenProp0051urease
GenProp0056type IV pilus
GenProp0062capsule
GenProp0154intrinsic pathogen of animals
GenProp0648phage shock protein regulon
GenProp0707botulinum toxin system
GenProp0849quorum-sensing, Bacillus PlcR-PapR system
GenProp0053type II secretion
GenProp0054type IV secretion
GenProp0059type I secretion
GenProp0127Tat (Sec-independent) protein export
GenProp0205signal recognition system, bacterial
GenProp0207lipoprotein localization system lolABCDE
GenProp0209Sec system preprotein translocase
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0326protein sorting system, PEP-CTERM/exosortase (generic)
GenProp0626protein sorting system, sortase type, LPXTG/SrtA class
GenProp0664protein sorting system, sortase type, SrtB class
GenProp0669protein sorting system, putative, exosortase G class
GenProp0735type VI secretion
GenProp0778protein sorting system, GlyGly-CTERM/rhombosortase
GenProp0844accessory Sec system for serine-rich glycoprotein transport
GenProp0845protein sorting system, KxYKxGKxW class
GenProp0847exosporium
GenProp0859protein sorting system, proteobacterial dedicated sortase type
GenProp0904type VII secretion, Actinobacteria form
GenProp0905type VII secretion, Firmicutes form
GenProp0928OMP chaperone system: SurA-Skp-DegP
GenProp0957protein sorting system, SipW class
GenProp0978protein sorting system, PGF-CTERM/archaeosortase A
GenProp0979protein sorting system, PEF-CTERM/archaeosortase C
GenProp0980protein sorting system, putative, exosortase F class
GenProp0983protein sorting system, VPXXXP-CTERM/archaeosortase B
GenProp0985protein sorting system, VPDSG-CTERM/exosortase C
GenProp0986protein sorting system, VPLPA-CTERM/exosortase D
GenProp0987protein sorting system, cyano-PEP-CTERM class
GenProp0989protein sorting system, VPEID-CTERM/exosortase E
GenProp0993protein sorting system, PIP-CTERM/archaeosortase D
GenProp0996protein sorting system, IPTLxxWG-CTERM/exosortase H
GenProp0999Por secretion system
GenProp1005protein sorting system, putative, exosortase J class
GenProp1054protein sorting system, MSEP-CTERM/exosortase K
GenProp1055protein sorting system, PEFG-CTERM/thaumarchaeosortase
GenProp1074type V secretion
GenProp1087protein sorting system, vault protein/exosortase N