Genome Property Definition Page

AccessionGenProp0061
Namelipoprotein system lgt/lsp/lnt
TypeSYSTEM
DescriptionYES NO Some membrane proteins are anchored to the membrane by a lipid moiety attached to a modified N-terminus rather than by a transmembrane helix. The characteristic enzymes of this modification system are lsp: prolipoprotein signal peptidase lgt: prolipoprotein diacylglycerol transferase lnt: apolipoprotein N-acyltransferase The modifications are cleavage (by Lsp) of the lipoprotein signal sequence at a motif resembling L-X-G/A-C to leave Cys as the new N-terminal residue, then modification of the Cys sulfhydryl by prolipoprotein diacylglyceryl transferase (Lgt), then acylation of the Cys NH2 by apolipoprotein N-acyltransferase (Lnt).
JCVI RoleProtein modification and repair
Parent PropertyGenProp0075: protein modification, prosthetic groups and cofactors
Gene Ontology TermGO:0006497: protein lipidation (biological_process)
GO:0042158: lipoprotein biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
prolipoprotein diacylglyceryl transferaselgtYESTIGR00544 (HMM): prolipoprotein diacylglyceryl transferaseGO:0006497: protein lipidation
GO:0042158: lipoprotein biosynthetic process
apolipoprotein N-acyltransferaselntNOTIGR00546 (HMM): apolipoprotein N-acyltransferaseGO:0006497: protein lipidation
GO:0042158: lipoprotein biosynthetic process
prolipoprotein signal peptidaselspYESTIGR00077 (HMM): signal peptidase IIGO:0006497: protein lipidation
GO:0042158: lipoprotein biosynthetic process

Parent Properties
AccessionName
GenProp0075protein modification, prosthetic groups and cofactors


Sibling Properties
AccessionName
GenProp0002coenzyme F420 utilization
GenProp0016selenocysteine system
GenProp0127Tat (Sec-independent) protein export
GenProp0284cobalamin-utilizing enzymes
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0726selenium-dependent molybdenum hydroxylase system
GenProp0745lipoyl-protein attachment
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0918anaerobic sulfatase/maturase system
GenProp0923mycothiol system
GenProp0933bacillithiol utilization
GenProp0938glycine radical enzyme system, YjjI/YjjW pair
GenProp0943pyruvate formate-lyase system
GenProp1080protein O-heptosyltransferase with autotransporter target