Genome Property Definition Page

Accession

GenProp0109

Name

histidine biosynthesis from ribose-5-phosphate

Type

PATHWAY

Description

Histidine is synthesized in a ten step pathway from phosphoribosyl-pyrophosphate. It is found in bacteria, archaebacteria, fungi, and plants. The early stage of this pathway takes a ribose and transforms it into Imadiazoleglycerol phosphate. Once the imadiazole ring is formed, glutamate donates the a-amino group and the newly formed amine is oxidized to histidine.[1] In Salmonella typhimurium and Escherichia coli, this pathway is carried out by the eight genes in his operon. HisI, hisB, hisD are bifunctional enzymes, hisF and hisH form a monofunctional dimer, and the rest are monofunctional enzymes.[1]

JCVI Role

Histidine family

Parent Property

GenProp0126: amino acid biosynthesis

Literature References

[ 1 ]Barbosa JA, Sivaraman J, Li Y, Larocque R, Matte A, Schrag JD, Cygler M. Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1859-64. Epub 2002 Feb 12. PMID 11842181
[ 2 ]Alifano P, Fani R, Lio P, Lazcano A, Bazzicalupo M, Carlomagno MS, Bruni CB. Histidine biosynthetic pathway and genes: structure, regulation, and evolution. Microbiol Rev. 1996 Mar;60(1):44-69. PMID 8852895

Web References

KEGG: Histidine Metabolism
IUBMB: Histidine Biosynthesis (early stages)
IUBMB: Histidine Biosynthesis (late stages)

Gene Ontology Term

GO:0000105: histidine biosynthetic process (biological_process)

Components

Step Name	Step Num	Required	Evidence (Method)	Evidence Go Terms
ribose-phosphate pyrophosphokinase		YES	TIGR01251 (HMM): ribose-phosphate diphosphokinase	GO:0000105: histidine biosynthetic process
phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	HisA	YES	TIGR00007 (HMM): 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase TIGR02129 (HMM): phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase TIGR01919 (HMM): bifunctional HisA/TrpF protein	GO:0000105: histidine biosynthetic process GO:0000105: histidine biosynthetic process GO:0000105: histidine biosynthetic process
imidazoleglycerol-phosphate dehydratase	HisB	YES	PF00475 (HMM): imidazoleglycerol-phosphate dehydratase	GO:0000105: histidine biosynthetic process
histidinol-phosphate aminotransferase	HisC	YES	TIGR01141 (HMM): histidinol-phosphate transaminase	GO:0000105: histidine biosynthetic process
histidinol dehydrogenase	HisD	YES	TIGR00069 (HMM): histidinol dehydrogenase PF00815 (HMM): histidinol dehydrogenase	GO:0000105: histidine biosynthetic process GO:0000105: histidine biosynthetic process
phosphoribosyl-ATP pyrophosphohydrolase	HisE	YES	PF01503 (HMM): phosphoribosyl-ATP diphosphatase TIGR03188 (HMM): phosphoribosyl-ATP diphosphatase	GO:0000105: histidine biosynthetic process GO:0000105: histidine biosynthetic process
imidazoleglycerol phosphate synthase, cyclase subunit	HisF	YES	TIGR00735 (HMM): imidazoleglycerol phosphate synthase, cyclase subunit	GO:0000105: histidine biosynthetic process
ATP phosphoribosyltransferase	HisG	YES	TIGR00070 (HMM): ATP phosphoribosyltransferase PF01634 (HMM): ATP phosphoribosyltransferase	GO:0000105: histidine biosynthetic process GO:0000105: histidine biosynthetic process
HisG, C-terminal domain	HisG_C	NO	PF08029 (HMM): HisG, C-terminal domain TIGR03455 (HMM): ATP phosphoribosyltransferase, C-terminal domain	GO:0000105: histidine biosynthetic process GO:0000105: histidine biosynthetic process
imidazoleglycerol phosphate synthase, glutamine amidotransferase subunit	HisH	YES	TIGR01855 (HMM): imidazole glycerol phosphate synthase, glutamine amidotransferase subunit	GO:0000105: histidine biosynthetic process
phosphoribosyl-AMP cyclohydrolase	HisI	YES	PF01502 (HMM): phosphoribosyl-AMP cyclohydrolase	GO:0000105: histidine biosynthetic process
histidinol-phosphate phosphatase	HisJ	NO	TIGR01261 (HMM): histidinol-phosphatase TIGR01856 (HMM): histidinol phosphate phosphatase, HisJ family TIGR02067 (HMM): histidinol-phosphatase	GO:0000105: histidine biosynthetic process
his operon leader peptide	HisL	NO	PF08047 (HMM): histidine operon leader peptide
ATP phosphoribosyltransferase regulatory subunit	HisZ	NO	TIGR00443 (HMM): ATP phosphoribosyltransferase, regulatory subunit	GO:0000105: histidine biosynthetic process

Parent Properties

Accession	Name
GenProp0126	amino acid biosynthesis

Sibling Properties

Accession	Name
GenProp0001	chorismate biosynthesis via shikimate
GenProp0016	selenocysteine system
GenProp0037	tryptophan biosynthesis from ribose-5-phosphate
GenProp0039	phenylalanine biosynthesis from chorismate
GenProp0045	tyrosine biosynthesis from chorismate
GenProp0087	arginine biosynthesis from glutatmate via N-acetylglutamate
GenProp0111	proline biosynthesis from glutamate
GenProp0117	arginine biosynthesis from ornithine, carbamoyl-p and aspartate
GenProp0118	ornithine biosynthesis from glutamate, acetylated branch
GenProp0159	threonine biosynthesis from aspartate semialdehyde
GenProp0160	aspartate semialdehyde biosynthesis from aspartate
GenProp0161	methionine biosynthesis from homoserine
GenProp0162	isoleucine biosynthesis from threonine and pyruvate
GenProp0163	valine biosynthesis from pyruvate
GenProp0164	leucine biosynthesis from pyruvate and acetyl-CoA
GenProp0178	glycine cleavage system
GenProp0199	lysine biosynthesis
GenProp0304	cysteine biosynthesis, tRNA-dependent
GenProp0305	cysteine biosynthesis
GenProp0729	methionine salvage from methylthioadenosine
GenProp0797	selenocysteinyl-tRNA, PSTK/SepSecS pathway