Genome Property Definition Page

AccessionGenProp0110
Namepurine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate
TypePATHWAY
DescriptionInosine-5-phosphate (IMP) is synthesized in a ten step pathway from phosphoribosyl- pyrophosphate (PRPP) and is the precursor of all purine nucleosides (adenosine, guanosine, inosine and xanthosine). The purine ring is build from glutamine (2 nitrogens), glycine (2 carbons and a nitrogen), 10-formyl-THF (2 carbons), carbon dioxide (1 carbon) and aspartate (1 nitrogen). An intermediate, AICAR-P, is formed during the process of histidine biosynthesis in a 1:1 ratio with histidine but this route is generally insufficient for fulfilling the purine needs of a dividing cell and is not considered _de novo_ purine biosynthesis.
JCVI RolePurine ribonucleotide biosynthesis
Parent PropertyGenProp0185: nucleotide biosynthesis
GenProp0185: nucleotide biosynthesis
GenProp0185: nucleotide biosynthesis
Web ReferencesKEGG: Purine metabolism
IUBMB: Purine Biosynthesis (early stages)
IUBMB: Purine Biosynthesis (late stages)
KEGG: Purine metabolism
IUBMB: Purine Biosynthesis (early stages)
IUBMB: Purine Biosynthesis (late stages)
KEGG: Purine metabolism
IUBMB: Purine Biosynthesis (early stages)
IUBMB: Purine Biosynthesis (late stages)
Gene Ontology TermGO:0006189: 'de novo' IMP biosynthetic process (biological_process)
GO:0006189: 'de novo' IMP biosynthetic process (biological_process)
GO:0006189: 'de novo' IMP biosynthetic process (biological_process)
GO:0006189: 'de novo' IMP biosynthetic process (biological_process)
GO:0006189: 'de novo' IMP biosynthetic process (biological_process)
GO:0006189: 'de novo' IMP biosynthetic process (biological_process)
GO:0006189: 'de novo' IMP biosynthetic process (biological_process)
GO:0006189: 'de novo' IMP biosynthetic process (biological_process)
GO:0006189: 'de novo' IMP biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
ribose-phosphate pyrophosphokinaseYESTIGR01251 (HMM): ribose-phosphate diphosphokinaseGO:0006189: 'de novo' IMP biosynthetic process
ribose-phosphate pyrophosphokinaseYESTIGR01251 (HMM): ribose-phosphate diphosphokinaseGO:0006189: 'de novo' IMP biosynthetic process
ribose-phosphate pyrophosphokinaseYESTIGR01251 (HMM): ribose-phosphate diphosphokinaseGO:0006189: 'de novo' IMP biosynthetic process
amidophosphoribosyltransferase1YESTIGR01134 (HMM): amidophosphoribosyltransferaseGO:0006189: 'de novo' IMP biosynthetic process
amidophosphoribosyltransferase1YESTIGR01134 (HMM): amidophosphoribosyltransferaseGO:0006189: 'de novo' IMP biosynthetic process
amidophosphoribosyltransferase1YESTIGR01134 (HMM): amidophosphoribosyltransferaseGO:0006189: 'de novo' IMP biosynthetic process
IMP cyclohydrolase10YESTIGR00355 (HMM): phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
TIGR01922 (HMM): IMP cyclohydrolase
PF01808 (HMM): AICARFT/IMPCHase bienzyme
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
IMP cyclohydrolase10YESTIGR00355 (HMM): phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
TIGR01922 (HMM): IMP cyclohydrolase
PF01808 (HMM): AICARFT/IMPCHase bienzyme
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
IMP cyclohydrolase10YESTIGR00355 (HMM): phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
TIGR01922 (HMM): IMP cyclohydrolase
PF01808 (HMM): AICARFT/IMPCHase bienzyme
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylamine--glycine ligase2YESTIGR00877 (HMM): phosphoribosylamine--glycine ligaseGO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylamine--glycine ligase2YESTIGR00877 (HMM): phosphoribosylamine--glycine ligaseGO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylamine--glycine ligase2YESTIGR00877 (HMM): phosphoribosylamine--glycine ligaseGO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylglycinamide formyltransferase3YESTIGR01142 (HMM): phosphoribosylglycinamide formyltransferase 2
TIGR00639 (HMM): phosphoribosylglycinamide formyltransferase
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylglycinamide formyltransferase3YESTIGR01142 (HMM): phosphoribosylglycinamide formyltransferase 2
TIGR00639 (HMM): phosphoribosylglycinamide formyltransferase
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylglycinamide formyltransferase3YESTIGR01142 (HMM): phosphoribosylglycinamide formyltransferase 2
TIGR00639 (HMM): phosphoribosylglycinamide formyltransferase
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylformylglycinamidine synthase I4AYESTIGR01735 (HMM): phosphoribosylformylglycinamidine synthase
TIGR01737 (HMM): phosphoribosylformylglycinamidine synthase I
TIGR01857 (HMM): phosphoribosylformylglycinamidine synthase
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylformylglycinamidine synthase I4AYESTIGR01735 (HMM): phosphoribosylformylglycinamidine synthase
TIGR01737 (HMM): phosphoribosylformylglycinamidine synthase I
TIGR01857 (HMM): phosphoribosylformylglycinamidine synthase
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylformylglycinamidine synthase I4AYESTIGR01735 (HMM): phosphoribosylformylglycinamidine synthase
TIGR01737 (HMM): phosphoribosylformylglycinamidine synthase I
TIGR01857 (HMM): phosphoribosylformylglycinamidine synthase
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylformylglycinamidine synthase II4BYESTIGR01735 (HMM): phosphoribosylformylglycinamidine synthase
TIGR01736 (HMM): phosphoribosylformylglycinamidine synthase II
TIGR01857 (HMM): phosphoribosylformylglycinamidine synthase
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylformylglycinamidine synthase II4BYESTIGR01735 (HMM): phosphoribosylformylglycinamidine synthase
TIGR01736 (HMM): phosphoribosylformylglycinamidine synthase II
TIGR01857 (HMM): phosphoribosylformylglycinamidine synthase
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylformylglycinamidine synthase II4BYESTIGR01735 (HMM): phosphoribosylformylglycinamidine synthase
TIGR01736 (HMM): phosphoribosylformylglycinamidine synthase II
TIGR01857 (HMM): phosphoribosylformylglycinamidine synthase
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylformylglycinamidine synthase III4CNOTIGR01735 (HMM): phosphoribosylformylglycinamidine synthase
TIGR00302 (HMM): phosphoribosylformylglycinamidine synthase, purS protein
TIGR01857 (HMM): phosphoribosylformylglycinamidine synthase
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylformylglycinamidine synthase III4CNOTIGR01735 (HMM): phosphoribosylformylglycinamidine synthase
TIGR00302 (HMM): phosphoribosylformylglycinamidine synthase, purS protein
TIGR01857 (HMM): phosphoribosylformylglycinamidine synthase
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylformylglycinamidine synthase III4CNOTIGR01735 (HMM): phosphoribosylformylglycinamidine synthase
TIGR00302 (HMM): phosphoribosylformylglycinamidine synthase, purS protein
TIGR01857 (HMM): phosphoribosylformylglycinamidine synthase
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylformylglycinamidine cyclo-ligase5YESTIGR00878 (HMM): phosphoribosylformylglycinamidine cyclo-ligaseGO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylformylglycinamidine cyclo-ligase5YESTIGR00878 (HMM): phosphoribosylformylglycinamidine cyclo-ligaseGO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylformylglycinamidine cyclo-ligase5YESTIGR00878 (HMM): phosphoribosylformylglycinamidine cyclo-ligaseGO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylaminoimidazole carboxylase, catalytic subunit6AYESTIGR01162 (HMM): phosphoribosylaminoimidazole carboxylase, catalytic subunitGO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylaminoimidazole carboxylase, catalytic subunit6AYESTIGR01162 (HMM): phosphoribosylaminoimidazole carboxylase, catalytic subunitGO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylaminoimidazole carboxylase, catalytic subunit6AYESTIGR01162 (HMM): phosphoribosylaminoimidazole carboxylase, catalytic subunitGO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylaminoimidazole carboxylase, ATPase subunit6BNOTIGR01161 (HMM): phosphoribosylaminoimidazole carboxylase, ATPase subunitGO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylaminoimidazole carboxylase, ATPase subunit6BNOTIGR01161 (HMM): phosphoribosylaminoimidazole carboxylase, ATPase subunitGO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylaminoimidazole carboxylase, ATPase subunit6BNOTIGR01161 (HMM): phosphoribosylaminoimidazole carboxylase, ATPase subunitGO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylaminoimidazole-succinocarboxamide synthase7YESTIGR00081 (HMM): phosphoribosylaminoimidazolesuccinocarboxamide synthase
TIGR02735 (HMM): phosphoribosylaminoimidazole-succinocarboxamide synthase
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylaminoimidazole-succinocarboxamide synthase7YESTIGR00081 (HMM): phosphoribosylaminoimidazolesuccinocarboxamide synthase
TIGR02735 (HMM): phosphoribosylaminoimidazole-succinocarboxamide synthase
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylaminoimidazole-succinocarboxamide synthase7YESTIGR00081 (HMM): phosphoribosylaminoimidazolesuccinocarboxamide synthase
TIGR02735 (HMM): phosphoribosylaminoimidazole-succinocarboxamide synthase
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
adenylosuccinate lyase8YESTIGR00928 (HMM): adenylosuccinate lyaseGO:0006189: 'de novo' IMP biosynthetic process
adenylosuccinate lyase8YESTIGR00928 (HMM): adenylosuccinate lyaseGO:0006189: 'de novo' IMP biosynthetic process
adenylosuccinate lyase8YESTIGR00928 (HMM): adenylosuccinate lyaseGO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylaminoimidazolecarboxamide formyltransferase9NOTIGR00355 (HMM): phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
PF01808 (HMM): AICARFT/IMPCHase bienzyme
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylaminoimidazolecarboxamide formyltransferase9NOTIGR00355 (HMM): phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
PF01808 (HMM): AICARFT/IMPCHase bienzyme
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process
phosphoribosylaminoimidazolecarboxamide formyltransferase9NOTIGR00355 (HMM): phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
PF01808 (HMM): AICARFT/IMPCHase bienzyme
GO:0006189: 'de novo' IMP biosynthetic process
GO:0006189: 'de novo' IMP biosynthetic process

Parent Properties
AccessionName
GenProp0185nucleotide biosynthesis
GenProp0185nucleotide biosynthesis
GenProp0185nucleotide biosynthesis


Sibling Properties
AccessionName
GenProp0187pyrimidine (uridine-5'-phosphate) de novo biosynthesis
GenProp0673ribulose monophosphate pathway
GenProp0696xanthine utilization as a source of guanine-monophosphate (GMP)
GenProp0697guanine monophosphate (GMP) biosynthesis from inosine monophosphate (IMP)
GenProp0747adenosine monophosphate (AMP) biosynthesis from inosine monophosphate (IMP)