Genome Property Definition Page

Nameriboflavin, FAD and FMN from GTP and ribulose-5-P
DescriptionFlavin-adenine dinucleotide (FAD) is synthesized via flavinmononucleotide (FMN) and riboflavin (vitamin B2) from GTP, ribulose-5-phosphate and ATP in a 9-step pathway. FAD and FMN are important carriers of hydrogen and electrons which are usually found tightly bound or covalently linked to enzymes such as dehydrogenases, oxidases and monooxygenases. The pathway in bacteria and archaea/fungi vary slightly with the order in which a pair of reductase and deaminase steps take place.
JCVI RoleRiboflavin, FMN, and FAD
Parent PropertyGenProp0184: cofactor biosynthesis
Web References

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
GTP cyclohydrolase II ( (HMM): GTP cyclohydrolase II
PF00925 (HMM): GTP cyclohydrolase II
pyrimidine deaminase ( (HMM): riboflavin biosynthesis protein RibD
TIGR00227 (HMM): riboflavin-specific deaminase C-terminal domain
uracil reductase ( (HMM): riboflavin biosynthesis protein RibD
PF01872 (HMM): riboflavin biosynthesis protein RibD C-terminal domain protein
TIGR01508 (HMM): diaminohydroxyphosphoribosylaminopyrimidine reductase
6,7-dimethyl-8-ribityllumazine synthase4YESTIGR00114 (HMM): 6,7-dimethyl-8-ribityllumazine synthase
riboflavin synthase ( (HMM): riboflavin synthase, alpha subunit
riboflavin kinase ( (HMM): riboflavin biosynthesis protein RibF
FAD synthetase ( (HMM): riboflavin biosynthesis protein RibF
3,4-dihydroxy-2-butanone 4-phosphate synthaseribBYESTIGR00506 (HMM): 3,4-dihydroxy-2-butanone-4-phosphate synthase

Parent Properties
GenProp0184cofactor biosynthesis

Sibling Properties
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis