Genome Property Definition Page

AccessionGenProp0124
Namepantothenate biosynthesis from aspartate and 2-oxoisovalerate
TypePATHWAY
DescriptionThis Genome Property tracks four proteins of pantothenate biosynthesis from aspartate. PanD, aspartate 1-decarboxylase, EC 4.1.1.11, makes beta-alanine. PanB, 3-methyl-2-oxobutanoate hydroxymethyltransferase, makes 2-dehydropantoate from 3-methyl-2-oxobutanoate. PanC, pantoate--beta-alanine ligase, EC 6.3.2.1, produces (R)-pantothenate from beta-alanine and (R)-pantoate. The genes for these three proteins tend to be clustered in bacterial genomes. The protein family distribution for a fourth component, PanE, is very different. The production of (R)-pantoate from 2-dehydropantoate can occur in more than one way (NADH or NADPH-dependent), and may be catalyzed by enzymes that may have additional important substrates (an example is the D-mandelate dehydrogenase of Enterococcus faecalis) and several such enzymes may be found in a genome.
JCVI RolePantothenate and coenzyme A
Parent PropertyGenProp0184: cofactor biosynthesis
Web ReferencesIUBMB: Coenzyme A Biosynthesis (early stages)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
3-methyl-2-oxobutanoate hydroxymethyltransferasepanBYESTIGR00222 (HMM): 3-methyl-2-oxobutanoate hydroxymethyltransferase
pantoate--beta-alanine ligasepanCYESTIGR00018 (HMM): pantoate--beta-alanine ligase
aspartate 1-decarboxylasepanDYESTIGR00223 (HMM): aspartate 1-decarboxylase
TIGR03799 (HMM): putative pyridoxal-dependent aspartate 1-decarboxylase
2-dehydropantoate 2-reductasepanENOTIGR00745 (HMM): 2-dehydropantoate 2-reductase

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis