Genome Property Definition Page

AccessionGenProp0136
Nameubiquinone biosynthesis from chorismate, aerobic
TypePATHWAY
DescriptionUbiquinone, an electron and hydrogen transport cofactor important for aerobic respiration and photosynthesis, is synthesized in bacteria from chorismate and polyprenyl pyrophosphates of varying lengths [1]. Knock out of the three hydroxylation steps requiring molecular oxygen results in anaerobic synthesis of ubiquinone, indicating the presence of an alternative system [2]. In yeast and animals a different pathway exists starting from 4-hydroxyphenylpyruvate, having latter steps in common with the bacterial pathway [3]. In addition to ubiquinone, bacteria may contain menaquinone and/or phylloquinone which together make up their quinone pool [1].
JCVI RoleMenaquinone and ubiquinone
Parent PropertyGenProp0184: cofactor biosynthesis
GenProp0838: lipid biosynthesis
Literature References
[ 2 ]Alexander K, Young IG.  Alternative hydroxylases for the aerobic and anaerobic biosynthesis of ubiquinone in Escherichia coli.  Biochemistry. 1978 Oct 31;17(22):4750-5.  PMID 365223
[ 3 ]Meganathan R.  Ubiquinone biosynthesis in microorganisms.  FEMS Microbiol Lett. 2001 Sep 25;203(2):131-9.  PMID 11583838
Web ReferencesKEGG: Ubiquinone metabolism
Gene Ontology TermGO:0006744: ubiquinone biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
4-hydroxybenzoate prenyltransferaseUbiAYESTIGR01475 (HMM): putative 4-hydroxybenzoate polyprenyltransferase
TIGR01474 (HMM): 4-hydroxybenzoate polyprenyl transferase
GO:0006744: ubiquinone biosynthetic process
GO:0006744: ubiquinone biosynthetic process
2-polyprenylphenol hydroxylaseUbiBYESTIGR01982 (HMM): 2-polyprenylphenol 6-hydroxylaseGO:0006744: ubiquinone biosynthetic process
chorismate-pyruvate lyaseUbiCNOPF04345 (HMM): chorismate lyase
3-prenyl-4-hydroxybenzoate decarboxylaseUbiD/XYESPF01977 (HMM): 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
TIGR00421 (HMM): polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases
GO:0006744: ubiquinone biosynthetic process
GO:0006744: ubiquinone biosynthetic process
ubiquinone biosynthesis C-methyltransferaseUbiEYESTIGR01934 (HMM): ubiquinone/menaquinone biosynthesis methyltransferase
ubiquinone biosynthesis 4- and 5-hydroxylasesUbiF/HYESTIGR01988 (HMM): ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family
PF03232 (HMM): ubiquinone biosynthesis protein COQ7
GO:0006744: ubiquinone biosynthetic process
GO:0006744: ubiquinone biosynthetic process
3-demethylubiquinone-9 3-methyltransferaseUbiGYESTIGR01983 (HMM): 3-demethylubiquinone-9 3-O-methyltransferaseGO:0006744: ubiquinone biosynthetic process

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis
GenProp0838lipid biosynthesis


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis
GenProp0046IPP biosynthesis
GenProp0297lipopolysaccharide biosynthesis
GenProp0299fatty acid biosynthesis
GenProp0758lycopene biosynthesis from IPP
GenProp0761hopanoid lipid biosynthesis
GenProp08371-acylglycerol-3-phosphate biosynthesis, PlsX/Y pathway