Genome Property Definition Page

Accession

GenProp0145

Name

histidine degradation to glutamate

Type

PATHWAY

Description

This pathway is involved in histidine utilization system (hut). HutP is the first gene in the hut operon encoding the hutHUIG operator and a positive regulator of the operon, activated allostatically in the presence of L-histidine. HutC represses the histidine utilization by binding the regulatory sites for the hutHUIG and hutF the divergent.In some species, histidine is converted to via urocanate and then formimino-L-glutamate to glutamate in four steps, where the fourth step is conversion of N-formimino-L-glutamate to L-glutamate and formamide. In others, that pathway from formimino-L-glutamate have two other possible alternatives. One is involved with the tetrahydrofolate (THF) dependent glutamate formiminotransferase interconverting L-glutamate and N-formimino-L-glutamate. The enzyme is bifunctional as it also catalyzes the cyclodeaminase reaction on N-formimino-THF, converting it to 5,10-methenyl-THF and releasing ammonia - part of the process of regenerating THF. The other alternative is involved with hutF (formiminoglutamate hydrolase).

JCVI Role

Amino acids and amines

Parent Property

GenProp0734: amino acid catabolism

Literature References

[ 1 ]Allison SL, Phillips AT. Nucleotide sequence of the gene encoding the repressor for the histidine utilization genes of Pseudomonas putida. J Bacteriol. 1990 Sep;172(9):5470-6. PMID 2203753
[ 2 ]Kaminskas E, Kimhi Y, Magasanik B. Urocanase and N-formimino-L-glutamate formiminohydrolase of Bacillus subtilis, two enzymes of the histidine degradation pathway. J Biol Chem. 1970 Jul 25;245(14):3536-44. PMID 4990470

Web References

KEGG: Histidine Metabolism
IUBMB: Histidine Catabolism

Gene Ontology Term

GO:0006548: histidine catabolic process (biological_process)

Components

Step Name	Step Num	Required	Evidence (Method)	Evidence Go Terms
histidine ammonia-lyase (hutH)	1	YES	TIGR01225 (HMM): histidine ammonia-lyase	GO:0006548: histidine catabolic process
urocanate hydratase (hutU)	2	YES	TIGR01228 (HMM): urocanate hydratase	GO:0006548: histidine catabolic process
imidazolonepropionase (hutI)	3	YES	TIGR01224 (HMM): imidazolonepropionase	GO:0006548: histidine catabolic process
formimidoylglutamate deiminase/formiminoglutamase/glu-formyltransferase	4/4A	YES	TIGR01227 (HMM): formimidoylglutamase TIGR02022 (HMM): formiminoglutamate deiminase TIGR02024 (HMM): glutamate formiminotransferase	GO:0006548: histidine catabolic process GO:0006548: histidine catabolic process GO:0006548: histidine catabolic process
formylglutamate deformylase/formiminoglutamase/glu-formyltransferase	4/4B	YES	TIGR01227 (HMM): formimidoylglutamase TIGR02017 (HMM): N-formylglutamate deformylase TIGR02024 (HMM): glutamate formiminotransferase	GO:0006548: histidine catabolic process GO:0006548: histidine catabolic process GO:0006548: histidine catabolic process
histidine utilization repressor (hutC)	reg	NO	TIGR02018 (HMM): histidine utilization repressor

Parent Properties

Accession	Name
GenProp0734	amino acid catabolism

Sibling Properties

Accession	Name
GenProp0139	degradation of tyrosine via homogentisate
GenProp0309	arginine catabolism to glutamate via arginine succinyltransferase (AST)
GenProp0456	attenuation system: tryptophanase
GenProp0639	arginine degradation via citrulline, ATP-generating
GenProp0659	tryptophan degradation to anthranilate