Genome Property Definition Page
| Accession | GenProp0145 | |
| Name | histidine degradation to glutamate | |
| Type | PATHWAY | |
| Description | This pathway is involved in histidine utilization system (hut). HutP is the first gene in the hut operon encoding the hutHUIG operator and a positive regulator of the operon, activated allostatically in the presence of L-histidine. HutC represses the histidine utilization by binding the regulatory sites for the hutHUIG and hutF the divergent.In some species, histidine is converted to via urocanate and then formimino-L-glutamate to glutamate in four steps, where the fourth step is conversion of N-formimino-L-glutamate to L-glutamate and formamide. In others, that pathway from formimino-L-glutamate have two other possible alternatives. One is involved with the tetrahydrofolate (THF) dependent glutamate formiminotransferase interconverting L-glutamate and N-formimino-L-glutamate. The enzyme is bifunctional as it also catalyzes the cyclodeaminase reaction on N-formimino-THF, converting it to 5,10-methenyl-THF and releasing ammonia - part of the process of regenerating THF. The other alternative is involved with hutF (formiminoglutamate hydrolase). | |
| JCVI Role | Amino acids and amines | |
| Parent Property | GenProp0734: amino acid catabolism | |
| Literature References |
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| Web References | KEGG: Histidine Metabolism IUBMB: Histidine Catabolism | |
| Gene Ontology Term | GO:0006548: histidine catabolic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| histidine ammonia-lyase (hutH) | 1 | YES | TIGR01225 (HMM): histidine ammonia-lyase | GO:0006548: histidine catabolic process |
| urocanate hydratase (hutU) | 2 | YES | TIGR01228 (HMM): urocanate hydratase | GO:0006548: histidine catabolic process |
| imidazolonepropionase (hutI) | 3 | YES | TIGR01224 (HMM): imidazolonepropionase | GO:0006548: histidine catabolic process |
| formimidoylglutamate deiminase/formiminoglutamase/glu-formyltransferase | 4/4A | YES | TIGR01227 (HMM): formimidoylglutamase TIGR02022 (HMM): formiminoglutamate deiminase TIGR02024 (HMM): glutamate formiminotransferase | GO:0006548: histidine catabolic process GO:0006548: histidine catabolic process GO:0006548: histidine catabolic process |
| formylglutamate deformylase/formiminoglutamase/glu-formyltransferase | 4/4B | YES | TIGR01227 (HMM): formimidoylglutamase TIGR02017 (HMM): N-formylglutamate deformylase TIGR02024 (HMM): glutamate formiminotransferase | GO:0006548: histidine catabolic process GO:0006548: histidine catabolic process GO:0006548: histidine catabolic process |
| histidine utilization repressor (hutC) | reg | NO | TIGR02018 (HMM): histidine utilization repressor |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0734 | amino acid catabolism |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0139 | degradation of tyrosine via homogentisate |
| GenProp0309 | arginine catabolism to glutamate via arginine succinyltransferase (AST) |
| GenProp0456 | attenuation system: tryptophanase |
| GenProp0639 | arginine degradation via citrulline, ATP-generating |
| GenProp0659 | tryptophan degradation to anthranilate |