Genome Property Definition Page

AccessionGenProp0145
Namehistidine degradation to glutamate
TypePATHWAY
DescriptionThis pathway is involved in histidine utilization system (hut). HutP is the first gene in the hut operon encoding the hutHUIG operator and a positive regulator of the operon, activated allostatically in the presence of L-histidine. HutC represses the histidine utilization by binding the regulatory sites for the hutHUIG and hutF the divergent.In some species, histidine is converted to via urocanate and then formimino-L-glutamate to glutamate in four steps, where the fourth step is conversion of N-formimino-L-glutamate to L-glutamate and formamide. In others, that pathway from formimino-L-glutamate have two other possible alternatives. One is involved with the tetrahydrofolate (THF) dependent glutamate formiminotransferase interconverting L-glutamate and N-formimino-L-glutamate. The enzyme is bifunctional as it also catalyzes the cyclodeaminase reaction on N-formimino-THF, converting it to 5,10-methenyl-THF and releasing ammonia - part of the process of regenerating THF. The other alternative is involved with hutF (formiminoglutamate hydrolase).
JCVI RoleAmino acids and amines
Parent PropertyGenProp0734: amino acid catabolism
GenProp0734: amino acid catabolism
GenProp0734: amino acid catabolism
Literature References
[ 1 ]Allison SL, Phillips AT.  Nucleotide sequence of the gene encoding the repressor for the histidine utilization genes of Pseudomonas putida.  J Bacteriol. 1990 Sep;172(9):5470-6.  PMID 2203753
[ 2 ]Kaminskas E, Kimhi Y, Magasanik B.  Urocanase and N-formimino-L-glutamate formiminohydrolase of Bacillus subtilis, two enzymes of the histidine degradation pathway.  J Biol Chem. 1970 Jul 25;245(14):3536-44.  PMID 4990470
[ 1 ]Allison SL, Phillips AT.  Nucleotide sequence of the gene encoding the repressor for the histidine utilization genes of Pseudomonas putida.  J Bacteriol. 1990 Sep;172(9):5470-6.  PMID 2203753
[ 2 ]Kaminskas E, Kimhi Y, Magasanik B.  Urocanase and N-formimino-L-glutamate formiminohydrolase of Bacillus subtilis, two enzymes of the histidine degradation pathway.  J Biol Chem. 1970 Jul 25;245(14):3536-44.  PMID 4990470
[ 1 ]Allison SL, Phillips AT.  Nucleotide sequence of the gene encoding the repressor for the histidine utilization genes of Pseudomonas putida.  J Bacteriol. 1990 Sep;172(9):5470-6.  PMID 2203753
[ 2 ]Kaminskas E, Kimhi Y, Magasanik B.  Urocanase and N-formimino-L-glutamate formiminohydrolase of Bacillus subtilis, two enzymes of the histidine degradation pathway.  J Biol Chem. 1970 Jul 25;245(14):3536-44.  PMID 4990470
Web ReferencesKEGG: Histidine Metabolism
IUBMB: Histidine Catabolism
KEGG: Histidine Metabolism
IUBMB: Histidine Catabolism
KEGG: Histidine Metabolism
IUBMB: Histidine Catabolism
Gene Ontology TermGO:0006548: histidine catabolic process (biological_process)
GO:0006548: histidine catabolic process (biological_process)
GO:0006548: histidine catabolic process (biological_process)
GO:0006548: histidine catabolic process (biological_process)
GO:0006548: histidine catabolic process (biological_process)
GO:0006548: histidine catabolic process (biological_process)
GO:0006548: histidine catabolic process (biological_process)
GO:0006548: histidine catabolic process (biological_process)
GO:0006548: histidine catabolic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
histidine ammonia-lyase (hutH)1YESTIGR01225 (HMM): histidine ammonia-lyaseGO:0006548: histidine catabolic process
histidine ammonia-lyase (hutH)1YESTIGR01225 (HMM): histidine ammonia-lyaseGO:0006548: histidine catabolic process
histidine ammonia-lyase (hutH)1YESTIGR01225 (HMM): histidine ammonia-lyaseGO:0006548: histidine catabolic process
urocanate hydratase (hutU)2YESTIGR01228 (HMM): urocanate hydrataseGO:0006548: histidine catabolic process
urocanate hydratase (hutU)2YESTIGR01228 (HMM): urocanate hydrataseGO:0006548: histidine catabolic process
urocanate hydratase (hutU)2YESTIGR01228 (HMM): urocanate hydrataseGO:0006548: histidine catabolic process
imidazolonepropionase (hutI)3YESTIGR01224 (HMM): imidazolonepropionaseGO:0006548: histidine catabolic process
imidazolonepropionase (hutI)3YESTIGR01224 (HMM): imidazolonepropionaseGO:0006548: histidine catabolic process
imidazolonepropionase (hutI)3YESTIGR01224 (HMM): imidazolonepropionaseGO:0006548: histidine catabolic process
formimidoylglutamate deiminase/formiminoglutamase/glu-formyltransferase4/4AYESTIGR01227 (HMM): formimidoylglutamase
TIGR02022 (HMM): formiminoglutamate deiminase
TIGR02024 (HMM): glutamate formiminotransferase
GO:0006548: histidine catabolic process
GO:0006548: histidine catabolic process
GO:0006548: histidine catabolic process
formimidoylglutamate deiminase/formiminoglutamase/glu-formyltransferase4/4AYESTIGR01227 (HMM): formimidoylglutamase
TIGR02022 (HMM): formiminoglutamate deiminase
TIGR02024 (HMM): glutamate formiminotransferase
GO:0006548: histidine catabolic process
GO:0006548: histidine catabolic process
GO:0006548: histidine catabolic process
formimidoylglutamate deiminase/formiminoglutamase/glu-formyltransferase4/4AYESTIGR01227 (HMM): formimidoylglutamase
TIGR02022 (HMM): formiminoglutamate deiminase
TIGR02024 (HMM): glutamate formiminotransferase
GO:0006548: histidine catabolic process
GO:0006548: histidine catabolic process
GO:0006548: histidine catabolic process
formylglutamate deformylase/formiminoglutamase/glu-formyltransferase4/4BYESTIGR01227 (HMM): formimidoylglutamase
TIGR02017 (HMM): N-formylglutamate deformylase
TIGR02024 (HMM): glutamate formiminotransferase
GO:0006548: histidine catabolic process
GO:0006548: histidine catabolic process
GO:0006548: histidine catabolic process
formylglutamate deformylase/formiminoglutamase/glu-formyltransferase4/4BYESTIGR01227 (HMM): formimidoylglutamase
TIGR02017 (HMM): N-formylglutamate deformylase
TIGR02024 (HMM): glutamate formiminotransferase
GO:0006548: histidine catabolic process
GO:0006548: histidine catabolic process
GO:0006548: histidine catabolic process
formylglutamate deformylase/formiminoglutamase/glu-formyltransferase4/4BYESTIGR01227 (HMM): formimidoylglutamase
TIGR02017 (HMM): N-formylglutamate deformylase
TIGR02024 (HMM): glutamate formiminotransferase
GO:0006548: histidine catabolic process
GO:0006548: histidine catabolic process
GO:0006548: histidine catabolic process
histidine utilization repressor (hutC)regNOTIGR02018 (HMM): histidine utilization repressor
histidine utilization repressor (hutC)regNOTIGR02018 (HMM): histidine utilization repressor
histidine utilization repressor (hutC)regNOTIGR02018 (HMM): histidine utilization repressor

Parent Properties
AccessionName
GenProp0734amino acid catabolism
GenProp0734amino acid catabolism
GenProp0734amino acid catabolism


Sibling Properties
AccessionName
GenProp0139degradation of tyrosine via homogentisate
GenProp0309arginine catabolism to glutamate via arginine succinyltransferase (AST)
GenProp0456attenuation system: tryptophanase
GenProp0639arginine degradation via citrulline, ATP-generating
GenProp0659tryptophan degradation to anthranilate