Genome Property Definition Page

AccessionGenProp0158
Namepeptidoglycan(murein) biosynthesis
TypeMETAPATH
DescriptionThis property describes 10 well-conserved steps in the biosynthesis of UDP-N-acetylmuramoyl-pentapeptide, a precursor of murein (peptidoglycan), from UDP-N-acetyl-D-glucosamine. A few pathogenic genera, such as Borrelia and Rickettsia, appear to import UDP-N-acetyl-D-glucosamine from their host rather than synthesize it from fructose-6-phosphate (see GenProp0750).
JCVI RoleBiosynthesis and degradation of murein sacculus and peptidoglycan
Parent PropertyGenProp0069: cell surface component
GenProp0186: storage and structural polymer biosynthesis
Web ReferencesIUBMB: Peptidoglycan Biosynthesis (Part 1)
IUBMB: Peptidoglycan Biosynthesis (Part 2)
IUBMB: Peptidoglycan Biosynthesis (Part 3)
MetaCyc: peptidoglycan biosynthesis I
MetaCyc: peptidoglycan biosynthesis II
Gene Ontology TermGO:0000270: peptidoglycan metabolic process (biological_process)
GO:0009252: peptidoglycan biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
Source of meso-2,6-diaminopimelate (DAP)DAPNOGenProp0125 (GENPROP): lysine biosynthesis via diaminopimelate (DAP)
GenProp0788 (GENPROP): lysine biosynthesis via diaminopimelate (DAP) utilizing ammonia and NADPH
GO:0009252: peptidoglycan biosynthetic process
GO:0009252: peptidoglycan biosynthetic process
Source of UDP-N-acetyl-D-glucosamineUDPAGNOGenProp0750 (GENPROP): UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate
GO:0009252: peptidoglycan biosynthetic process
alanine racemasealrYESTIGR00492 (HMM): alanine racemaseGO:0009252: peptidoglycan biosynthetic process
D-alanine--D-alanine ligaseddlYESTIGR01205 (HMM): D-alanine--D-alanine ligaseGO:0009252: peptidoglycan biosynthetic process
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligasemplNOTIGR01081 (HMM): UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligaseGO:0009252: peptidoglycan biosynthetic process
phospho-N-acetylmuramoyl-pentapeptide-transferasemraYYESTIGR00445 (HMM): phospho-N-acetylmuramoyl-pentapeptide-transferaseGO:0009252: peptidoglycan biosynthetic process
UDP-N-acetylglucosamine 1-carboxyvinyltransferasemurAYESTIGR01072 (HMM): UDP-N-acetylglucosamine 1-carboxyvinyltransferaseGO:0009252: peptidoglycan biosynthetic process
UDP-N-acetylenolpyruvoylglucosamine reductasemurBYESTIGR00179 (HMM): UDP-N-acetylenolpyruvoylglucosamine reductaseGO:0009252: peptidoglycan biosynthetic process
UDP-N-acetylmuramate--alanine ligasemurCYESTIGR01082 (HMM): UDP-N-acetylmuramate--L-alanine ligaseGO:0009252: peptidoglycan biosynthetic process
UDP-N-acetylmuramoylalanine--D-glutamate ligasemurDYESTIGR01087 (HMM): UDP-N-acetylmuramoylalanine--D-glutamate ligaseGO:0009252: peptidoglycan biosynthetic process
UDP-N-acetylmuramyl-tripeptide synthetasemurEYESTIGR01085 (HMM): UDP-N-acetylmuramyl-tripeptide synthetaseGO:0009252: peptidoglycan biosynthetic process
UDP-N-acetylmuramyl-pentapeptide synthetasemurFYESTIGR01143 (HMM): UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligaseGO:0009252: peptidoglycan biosynthetic process
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferasemurGYESTIGR01133 (HMM): undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferaseGO:0009252: peptidoglycan biosynthetic process
glutamate racemasemurIYESTIGR00067 (HMM): glutamate racemaseGO:0009252: peptidoglycan biosynthetic process
peptidoglycan biosynthetic transglycosylasestrnsGlyYESPF00912 (HMM): transglycosylaseGO:0009252: peptidoglycan biosynthetic process
peptidoglycan-biosynthetic transpeptidasestrnsPepYESPF00905 (HMM): penicillin-binding protein, transpeptidase domainGO:0009252: peptidoglycan biosynthetic process

Parent Properties
AccessionName
GenProp0069cell surface component
GenProp0186storage and structural polymer biosynthesis


Sibling Properties
AccessionName
GenProp0007flagella
GenProp0012outer membrane
GenProp0022S-layer
GenProp0056type IV pilus
GenProp0062capsule
GenProp0297lipopolysaccharide biosynthesis
GenProp0326protein sorting system, PEP-CTERM/exosortase (generic)
GenProp0626protein sorting system, sortase type, LPXTG/SrtA class
GenProp0664protein sorting system, sortase type, SrtB class
GenProp0725outer membrane protein assembly complex
GenProp0811S-layer homology domain-mediated cell wall binding
GenProp0847exosporium
GenProp0857anchored repeat-class ABC transporter, P. acnes type
GenProp0859protein sorting system, proteobacterial dedicated sortase type
GenProp0055polyhydroxyalkanoic acids
GenProp0156cyanophycin-like storage polymers
GenProp0168glycogen system
GenProp0183dTDP-L-rhamnose biosynthesis from dTDP-4-dehydro-L-rhamnose
GenProp0652exopolysaccharide biosynthesis, exosortase A-associated
GenProp0655exopolysaccharide biosynthesis, exosortase B-associated
GenProp0658cellulose biosynthesis
GenProp0793CMP-N-acetylneuraminate biosynthesis from UDP-N-acetylglucosamine
GenProp0822poly(gamma-glutamic acid) biosynthesis
GenProp0906poly-beta-1,6 N-acetyl-D-glucosamine system, IcaADBC type
GenProp0907poly-beta-1,6 N-acetyl-D-glucosamine system, PgaABCD type