Genome Property Definition Page

Namethreonine biosynthesis from aspartate semialdehyde
DescriptionThreonine is made from aspartate semialdehyde, a branch point intermediate in the synthesis of lysine. The aspartate semialdehyde is derived from aspartate, which in turn is derived from the Krebs cycle intermediate oxaloacetate. Homoserine, an intermediate in this pathway is a branchpoint for the biosynthesis of methionine. Threonine itself is utilized as a starting point for the biosynthesis of isoleucine.
JCVI RoleAspartate family
Parent PropertyGenProp0126: amino acid biosynthesis
Web ReferencesIUBMB: Threonine Biosynthesis
KEGG: Glycine, serine and threonine metabolism
Gene Ontology TermGO:0009088: threonine biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
homoserine dehydrogenaseHS_DHYESPF00742 (HMM): homoserine dehydrogenaseGO:0009088: threonine biosynthetic process
homoserine kinaseHS_kinYESTIGR00191 (HMM): homoserine kinase
TIGR00938 (HMM): homoserine kinase
TIGR02137 (HMM): phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein
GO:0009088: threonine biosynthetic process
GO:0009088: threonine biosynthetic process
GO:0009088: threonine biosynthetic process
hypothetical NOD for homoserine kinasehyp_HSKNOTIGR02535 (HMM): proposed homoserine kinase
threonine synthasethr_synYESTIGR00260 (HMM): threonine synthaseGO:0009088: threonine biosynthetic process

Parent Properties
GenProp0126amino acid biosynthesis

Sibling Properties
GenProp0001chorismate biosynthesis via shikimate
GenProp0016selenocysteine system
GenProp0037tryptophan biosynthesis from ribose-5-phosphate
GenProp0039phenylalanine biosynthesis from chorismate
GenProp0045tyrosine biosynthesis from chorismate
GenProp0087arginine biosynthesis from glutatmate via N-acetylglutamate
GenProp0109histidine biosynthesis from ribose-5-phosphate
GenProp0111proline biosynthesis from glutamate
GenProp0117arginine biosynthesis from ornithine, carbamoyl-p and aspartate
GenProp0118ornithine biosynthesis from glutamate, acetylated branch
GenProp0160aspartate semialdehyde biosynthesis from aspartate
GenProp0161methionine biosynthesis from homoserine
GenProp0162isoleucine biosynthesis from threonine and pyruvate
GenProp0163valine biosynthesis from pyruvate
GenProp0164leucine biosynthesis from pyruvate and acetyl-CoA
GenProp0178glycine cleavage system
GenProp0199lysine biosynthesis
GenProp0304cysteine biosynthesis, tRNA-dependent
GenProp0305cysteine biosynthesis
GenProp0729methionine salvage from methylthioadenosine
GenProp0797selenocysteinyl-tRNA, PSTK/SepSecS pathway