Genome Property Definition Page

AccessionGenProp0161
Namemethionine biosynthesis from homoserine
TypePATHWAY
DescriptionHomoserine (which is also threonine precursor) may be succinylated or acetylated in the first step of methionine biosynthesis in bacteria. The second step removes the acyl group but adds sulfur from cysteine to form cystathionine. Cystathione beta-lyase cleaves cystathionine to produce homocysteine, which is methylated to form methionine.
JCVI RoleAspartate family
Parent PropertyGenProp0126: amino acid biosynthesis
GenProp0196: sulfur metabolism
GenProp0126: amino acid biosynthesis
GenProp0196: sulfur metabolism
GenProp0126: amino acid biosynthesis
GenProp0196: sulfur metabolism
Gene Ontology TermGO:0019279: L-methionine biosynthetic process from L-homoserine via cystathionine (biological_process)
GO:0019279: L-methionine biosynthetic process from L-homoserine via cystathionine (biological_process)
GO:0019279: L-methionine biosynthetic process from L-homoserine via cystathionine (biological_process)
GO:0019280: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine (biological_process)
GO:0019280: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine (biological_process)
GO:0019280: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine (biological_process)
GO:0019281: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine (biological_process)
GO:0019281: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine (biological_process)
GO:0019281: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine (biological_process)
GO:0019279: L-methionine biosynthetic process from L-homoserine via cystathionine (biological_process)
GO:0019279: L-methionine biosynthetic process from L-homoserine via cystathionine (biological_process)
GO:0019279: L-methionine biosynthetic process from L-homoserine via cystathionine (biological_process)
GO:0019280: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine (biological_process)
GO:0019280: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine (biological_process)
GO:0019280: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine (biological_process)
GO:0019281: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine (biological_process)
GO:0019281: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine (biological_process)
GO:0019281: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine (biological_process)
GO:0019279: L-methionine biosynthetic process from L-homoserine via cystathionine (biological_process)
GO:0019279: L-methionine biosynthetic process from L-homoserine via cystathionine (biological_process)
GO:0019279: L-methionine biosynthetic process from L-homoserine via cystathionine (biological_process)
GO:0019280: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine (biological_process)
GO:0019280: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine (biological_process)
GO:0019280: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine (biological_process)
GO:0019281: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine (biological_process)
GO:0019281: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine (biological_process)
GO:0019281: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go TermsBranch
O-acetylhomoserine (thiol)-lyaseAcSulfNOTIGR01326 (HMM): O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase
TIGR01326 (HMM): O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase
1
O-acetylhomoserine (thiol)-lyaseAcSulfNOTIGR01326 (HMM): O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase
TIGR01326 (HMM): O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase
1
O-acetylhomoserine (thiol)-lyaseAcSulfNOTIGR01326 (HMM): O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase
TIGR01326 (HMM): O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase
1
methylation of homocysteine (various)lastYESTIGR01371 (HMM): 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
TIGR02082 (HMM): methionine synthase
TIGR01371 (HMM): 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
TIGR02082 (HMM): methionine synthase
1
methylation of homocysteine (various)lastYESTIGR01371 (HMM): 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
TIGR02082 (HMM): methionine synthase
TIGR01371 (HMM): 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
TIGR02082 (HMM): methionine synthase
1
methylation of homocysteine (various)lastYESTIGR01371 (HMM): 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
TIGR02082 (HMM): methionine synthase
TIGR01371 (HMM): 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
TIGR02082 (HMM): methionine synthase
1
homoserine O-succinyltransferasemetAYESTIGR01001 (HMM): homoserine O-succinyltransferase
TIGR01001 (HMM): homoserine O-succinyltransferase
succinyl
homoserine O-succinyltransferasemetAYESTIGR01001 (HMM): homoserine O-succinyltransferase
TIGR01001 (HMM): homoserine O-succinyltransferase
succinyl
homoserine O-succinyltransferasemetAYESTIGR01001 (HMM): homoserine O-succinyltransferase
TIGR01001 (HMM): homoserine O-succinyltransferase
succinyl
cystathione gamma-synthase, acetyl branchmetB_acYESdirect assertion (MANUAL)

direct assertion (MANUAL)
acet
cystathione gamma-synthase, acetyl branchmetB_acYESdirect assertion (MANUAL)

direct assertion (MANUAL)
acet
cystathione gamma-synthase, acetyl branchmetB_acYESdirect assertion (MANUAL)

direct assertion (MANUAL)
acet
cystathione gamma-synthase, succinyl branchmetB_sucYESTIGR02080 (HMM): O-succinylhomoserine (thiol)-lyase
TIGR02080 (HMM): O-succinylhomoserine (thiol)-lyase
succinyl
cystathione gamma-synthase, succinyl branchmetB_sucYESTIGR02080 (HMM): O-succinylhomoserine (thiol)-lyase
TIGR02080 (HMM): O-succinylhomoserine (thiol)-lyase
succinyl
cystathione gamma-synthase, succinyl branchmetB_sucYESTIGR02080 (HMM): O-succinylhomoserine (thiol)-lyase
TIGR02080 (HMM): O-succinylhomoserine (thiol)-lyase
succinyl
cystathionine beta-lyasemetCYESTIGR01324 (HMM): cystathionine beta-lyase
TIGR01329 (HMM): cystathionine beta-lyase
TIGR01324 (HMM): cystathionine beta-lyase
TIGR01329 (HMM): cystathionine beta-lyase
1
cystathionine beta-lyasemetCYESTIGR01324 (HMM): cystathionine beta-lyase
TIGR01329 (HMM): cystathionine beta-lyase
TIGR01324 (HMM): cystathionine beta-lyase
TIGR01329 (HMM): cystathionine beta-lyase
1
cystathionine beta-lyasemetCYESTIGR01324 (HMM): cystathionine beta-lyase
TIGR01329 (HMM): cystathionine beta-lyase
TIGR01324 (HMM): cystathionine beta-lyase
TIGR01329 (HMM): cystathionine beta-lyase
1
5,10-methyleneTHF reductasemetFNOTIGR00676 (HMM): methylenetetrahydrofolate reductase [NAD(P)H]
TIGR00676 (HMM): methylenetetrahydrofolate reductase [NAD(P)H]
1
5,10-methyleneTHF reductasemetFNOTIGR00676 (HMM): methylenetetrahydrofolate reductase [NAD(P)H]
TIGR00676 (HMM): methylenetetrahydrofolate reductase [NAD(P)H]
1
5,10-methyleneTHF reductasemetFNOTIGR00676 (HMM): methylenetetrahydrofolate reductase [NAD(P)H]
TIGR00676 (HMM): methylenetetrahydrofolate reductase [NAD(P)H]
1
methionine biosynthesis protein MetWmetWNOTIGR02081 (HMM): methionine biosynthesis protein MetW
TIGR02081 (HMM): methionine biosynthesis protein MetW
succinyl
methionine biosynthesis protein MetWmetWNOTIGR02081 (HMM): methionine biosynthesis protein MetW
TIGR02081 (HMM): methionine biosynthesis protein MetW
succinyl
methionine biosynthesis protein MetWmetWNOTIGR02081 (HMM): methionine biosynthesis protein MetW
TIGR02081 (HMM): methionine biosynthesis protein MetW
succinyl
homoserine O-acetyltransferasemetXYESTIGR01392 (HMM): homoserine O-acetyltransferase
TIGR01392 (HMM): homoserine O-acetyltransferase
acet
homoserine O-acetyltransferasemetXYESTIGR01392 (HMM): homoserine O-acetyltransferase
TIGR01392 (HMM): homoserine O-acetyltransferase
acet
homoserine O-acetyltransferasemetXYESTIGR01392 (HMM): homoserine O-acetyltransferase
TIGR01392 (HMM): homoserine O-acetyltransferase
acet
O-succinylhomoserine sulfhydrylasemetZNOTIGR01325 (HMM): O-succinylhomoserine sulfhydrylase
TIGR01325 (HMM): O-succinylhomoserine sulfhydrylase
1
O-succinylhomoserine sulfhydrylasemetZNOTIGR01325 (HMM): O-succinylhomoserine sulfhydrylase
TIGR01325 (HMM): O-succinylhomoserine sulfhydrylase
1
O-succinylhomoserine sulfhydrylasemetZNOTIGR01325 (HMM): O-succinylhomoserine sulfhydrylase
TIGR01325 (HMM): O-succinylhomoserine sulfhydrylase
1

Parent Properties
AccessionName
GenProp0126amino acid biosynthesis
GenProp0196sulfur metabolism
GenProp0126amino acid biosynthesis
GenProp0196sulfur metabolism
GenProp0126amino acid biosynthesis
GenProp0196sulfur metabolism


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0016selenocysteine system
GenProp0037tryptophan biosynthesis from ribose-5-phosphate
GenProp0039phenylalanine biosynthesis from chorismate
GenProp0045tyrosine biosynthesis from chorismate
GenProp0087arginine biosynthesis from glutatmate via N-acetylglutamate
GenProp0109histidine biosynthesis from ribose-5-phosphate
GenProp0111proline biosynthesis from glutamate
GenProp0117arginine biosynthesis from ornithine, carbamoyl-p and aspartate
GenProp0118ornithine biosynthesis from glutamate, acetylated branch
GenProp0159threonine biosynthesis from aspartate semialdehyde
GenProp0160aspartate semialdehyde biosynthesis from aspartate
GenProp0162isoleucine biosynthesis from threonine and pyruvate
GenProp0163valine biosynthesis from pyruvate
GenProp0164leucine biosynthesis from pyruvate and acetyl-CoA
GenProp0178glycine cleavage system
GenProp0199lysine biosynthesis
GenProp0304cysteine biosynthesis, tRNA-dependent
GenProp0305cysteine biosynthesis
GenProp0729methionine salvage from methylthioadenosine
GenProp0797selenocysteinyl-tRNA, PSTK/SepSecS pathway
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0140iron-sulfur cluster assembly systems
GenProp0149sulfate reduction to sulfide, assimilatory
GenProp0155dissimilatory sulfate reduction
GenProp0182reduction of oxidized methionine
GenProp0191sulfate/thiosulfate ABC transporter
GenProp0624sulfite reductase complex, Salmonella/Clostridium type
GenProp0654intracellular sulfur oxidation