Genome Property Definition Page

Namevaline biosynthesis from pyruvate
DescriptionThe branched amino acid valine is biosynthesized from the central intermediary metabolite pyruvate via a four step pathway. All four enzymes in this pathway are common to the pathways for the biosynthesis of isoleucine from 2-oxobutyrate and leucine from pyruvate, although specialized versions of these enzymes may exist in certain species which have a narrowed substrate range or amino acid-specific regulatory mechanisms. The product of the third step in this pathway, 2-oxoisovalerate is a branchpoint metabolite required for the biosynthesis of Coenzyme A, branched-chain fatty acids, and leucine. Similarly, the product of the first step, (S)-2-acetolactate is common to the pathway to (R,R)-2,3-butanediol in the mixed-acid fermentation of pyruvate. The first step of the pathway, acetolactate synthase, requires thiamine pyrophosphate and two molecules of pyruvate, one of which is decarboxylated to the acetoacetate adduct, 2-(alpha-hydroxyethyl)-ThPP [1].
JCVI RolePyruvate family
Parent PropertyGenProp0126: amino acid biosynthesis
Web ReferencesKEGG: Valine, leucine and isoleucine biosynthesis
IUBMB: Isoleucine and Valine Biosynthesis
Gene Ontology TermGO:0009099: valine biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
acetohydroxyacid synthase, large subunitVal_1aYESTIGR00118 (HMM): acetolactate synthase, large subunit, biosynthetic typeGO:0009099: valine biosynthetic process
acetohydroxyacid synthase, small subunitVal_1bNOTIGR00119 (HMM): acetolactate synthase, small subunitGO:0009099: valine biosynthetic process
ketol-acid reductoisomeraseVal_2YESTIGR00465 (HMM): ketol-acid reductoisomeraseGO:0009099: valine biosynthetic process
dihydroxy-acid dehydrataseVal_3YESTIGR00110 (HMM): dihydroxy-acid dehydrataseGO:0009099: valine biosynthetic process
branched-chain amino acid aminotransferaseVal_4NOTIGR01122 (HMM): branched-chain amino acid aminotransferase
TIGR01123 (HMM): branched-chain amino acid aminotransferase
GO:0009099: valine biosynthetic process
GO:0009099: valine biosynthetic process

Parent Properties
GenProp0126amino acid biosynthesis

Sibling Properties
GenProp0001chorismate biosynthesis via shikimate
GenProp0016selenocysteine system
GenProp0037tryptophan biosynthesis from ribose-5-phosphate
GenProp0039phenylalanine biosynthesis from chorismate
GenProp0045tyrosine biosynthesis from chorismate
GenProp0087arginine biosynthesis from glutatmate via N-acetylglutamate
GenProp0109histidine biosynthesis from ribose-5-phosphate
GenProp0111proline biosynthesis from glutamate
GenProp0117arginine biosynthesis from ornithine, carbamoyl-p and aspartate
GenProp0118ornithine biosynthesis from glutamate, acetylated branch
GenProp0159threonine biosynthesis from aspartate semialdehyde
GenProp0160aspartate semialdehyde biosynthesis from aspartate
GenProp0161methionine biosynthesis from homoserine
GenProp0162isoleucine biosynthesis from threonine and pyruvate
GenProp0164leucine biosynthesis from pyruvate and acetyl-CoA
GenProp0178glycine cleavage system
GenProp0199lysine biosynthesis
GenProp0304cysteine biosynthesis, tRNA-dependent
GenProp0305cysteine biosynthesis
GenProp0729methionine salvage from methylthioadenosine
GenProp0797selenocysteinyl-tRNA, PSTK/SepSecS pathway