Genome Property Definition Page

AccessionGenProp0170
Namecoenzyme PQQ biosynthesis
TypeSYSTEM
DescriptionCoenzyme PQQ (coenzyme pyrrolo-quinoline-quinone) production is associated with an operon that includes a small protein, PqqA, proposed to act as a molecular precursor. PQQ is a cofactor of certain alcohol dehydrogenases and glucose dehydrogenases.
JCVI RoleOther
Parent PropertyGenProp0184: cofactor biosynthesis
Literature References
[ 1 ] Puehringer S, Metlitzky M, Schwarzenbacher R   The pyrroloquinoline quinone biosynthesis pathway revisited: a structural approach.   BMC Biochem. 2008 Mar 27;9:8  PMID 18371220
Gene Ontology TermGO:0018189: pyrroloquinoline quinone biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
PQQ-binding repeatsPQQ_rptNOPF01011 (HMM): PQQ enzyme repeat
PqqA proteinpqqAYESTIGR02107 (HMM): coenzyme PQQ precursor peptide PqqAGO:0018189: pyrroloquinoline quinone biosynthetic process
PqqB proteinpqqBYESTIGR02108 (HMM): coenzyme PQQ biosynthesis protein BGO:0018189: pyrroloquinoline quinone biosynthetic process
PqqC proteinpqqCYESTIGR02111 (HMM): coenzyme PQQ biosynthesis protein CGO:0018189: pyrroloquinoline quinone biosynthetic process
PqqD proteinpqqDYESTIGR03859 (HMM): coenzyme PQQ biosynthesis protein PqqDGO:0018189: pyrroloquinoline quinone biosynthetic process
PqqE proteinpqqEYESTIGR02109 (HMM): coenzyme PQQ biosynthesis enzyme PqqEGO:0018189: pyrroloquinoline quinone biosynthetic process
peptidase PqqFpqqFNOTIGR02110 (HMM): coenzyme PQQ biosynthesis protein PqqFGO:0018189: pyrroloquinoline quinone biosynthetic process
PQQ-dependent enzyme exampleusePQQYESTIGR03074 (HMM): membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family
TIGR03075 (HMM): PQQ-dependent dehydrogenase, methanol/ethanol family
GO:0018189: pyrroloquinoline quinone biosynthetic process
GO:0018189: pyrroloquinoline quinone biosynthetic process

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis