Genome Property Definition Page
| Accession | GenProp0182 |
| Name | reduction of oxidized methionine |
| Type | GUILD |
| Description | Methionine, free or in proteins, is susceptible to oxidation damage. R- and S-conformation enantiomers of methionine sulfoxide can be repaired by different reductases. MsrB (TIGR00357) was previously designated PilB because of altered cytoadherence in a mutant. MsrA and MsrB are sometimes expressed as a fusion protein. |
| JCVI Role | Protein modification and repair |
| Parent Property | GenProp0196: sulfur metabolism GenProp0302: protein repair GenProp0733: amino acid salvage |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| methionine-S-sulfoxide reductase | MsrA | YES | TIGR00401 (HMM): peptide-methionine (S)-S-oxide reductase | |
| methionine-R-sulfoxide reductase | MsrB | YES | TIGR00357 (HMM): methionine-R-sulfoxide reductase |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0196 | sulfur metabolism |
| GenProp0302 | protein repair |
| GenProp0733 | amino acid salvage |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0030 | glutathione biosynthesis |
| GenProp0036 | biotin biosynthesis |
| GenProp0140 | iron-sulfur cluster assembly systems |
| GenProp0149 | sulfate reduction to sulfide, assimilatory |
| GenProp0155 | dissimilatory sulfate reduction |
| GenProp0161 | methionine biosynthesis from homoserine |
| GenProp0191 | sulfate/thiosulfate ABC transporter |
| GenProp0624 | sulfite reductase complex, Salmonella/Clostridium type |
| GenProp0654 | intracellular sulfur oxidation |
| GenProp0729 | methionine salvage from methylthioadenosine |