Genome Property Definition Page

AccessionGenProp0187
Namepyrimidine (uridine-5'-phosphate) de novo biosynthesis
TypePATHWAY
DescriptionDe novo pyrimidine biosynthesis procedes from CO2 (bicarbonate), an NH2 group from glutamine or free ammonia, and aspartate. A ring compound, N-carbomoyl-L-aspartate is formed, then converted in two more steps into orotate. The ribose moiety is then added from alpha-D-5-P-ribosylpyrophosphate (PRPP), which is also a precursor of purines, histidine, and tryptophan. The resulting orotidine monophosphate is decarboxylated to uridine monophosphate (UMP), a pyrimidine nucleotide from which other pyrimidines are made. The few species lacking pyrimidine de novo biosynthesis include some members of the Chlamydiae, Mycoplasmatales, Rickettsiales, and Spirochaetes.
JCVI RolePyrimidine ribonucleotide biosynthesis
Parent PropertyGenProp0185: nucleotide biosynthesis
GenProp0185: nucleotide biosynthesis
GenProp0185: nucleotide biosynthesis
Web ReferencesKEGG: Pyrimidine metabolism
IUBMB: Pyrimidine Biosynthesis
KEGG: Pyrimidine metabolism
IUBMB: Pyrimidine Biosynthesis
KEGG: Pyrimidine metabolism
IUBMB: Pyrimidine Biosynthesis
Gene Ontology TermGO:0006222: UMP biosynthetic process (biological_process)
GO:0006222: UMP biosynthetic process (biological_process)
GO:0006222: UMP biosynthetic process (biological_process)
GO:0006222: UMP biosynthetic process (biological_process)
GO:0006222: UMP biosynthetic process (biological_process)
GO:0006222: UMP biosynthetic process (biological_process)
GO:0006222: UMP biosynthetic process (biological_process)
GO:0006222: UMP biosynthetic process (biological_process)
GO:0006222: UMP biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
ribose-phosphate pyrophosphokinasePRPPsynYESTIGR01251 (HMM): ribose-phosphate diphosphokinase
TIGR01251 (HMM): ribose-phosphate diphosphokinase
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
ribose-phosphate pyrophosphokinasePRPPsynYESTIGR01251 (HMM): ribose-phosphate diphosphokinase
TIGR01251 (HMM): ribose-phosphate diphosphokinase
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
ribose-phosphate pyrophosphokinasePRPPsynYESTIGR01251 (HMM): ribose-phosphate diphosphokinase
TIGR01251 (HMM): ribose-phosphate diphosphokinase
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
carbamoyl-phosphate synthase, small subunitcarAYESTIGR01368 (HMM): carbamoyl-phosphate synthase, small subunit
TIGR01368 (HMM): carbamoyl-phosphate synthase, small subunit
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
carbamoyl-phosphate synthase, small subunitcarAYESTIGR01368 (HMM): carbamoyl-phosphate synthase, small subunit
TIGR01368 (HMM): carbamoyl-phosphate synthase, small subunit
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
carbamoyl-phosphate synthase, small subunitcarAYESTIGR01368 (HMM): carbamoyl-phosphate synthase, small subunit
TIGR01368 (HMM): carbamoyl-phosphate synthase, small subunit
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
carbamoyl-phosphate synthase, large subunitcarBYESTIGR01369 (HMM): carbamoyl-phosphate synthase, large subunit
TIGR01369 (HMM): carbamoyl-phosphate synthase, large subunit
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
carbamoyl-phosphate synthase, large subunitcarBYESTIGR01369 (HMM): carbamoyl-phosphate synthase, large subunit
TIGR01369 (HMM): carbamoyl-phosphate synthase, large subunit
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
carbamoyl-phosphate synthase, large subunitcarBYESTIGR01369 (HMM): carbamoyl-phosphate synthase, large subunit
TIGR01369 (HMM): carbamoyl-phosphate synthase, large subunit
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
aspartate carbamoyltransferasepyrBYESTIGR00670 (HMM): aspartate carbamoyltransferase
TIGR00670 (HMM): aspartate carbamoyltransferase
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
aspartate carbamoyltransferasepyrBYESTIGR00670 (HMM): aspartate carbamoyltransferase
TIGR00670 (HMM): aspartate carbamoyltransferase
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
aspartate carbamoyltransferasepyrBYESTIGR00670 (HMM): aspartate carbamoyltransferase
TIGR00670 (HMM): aspartate carbamoyltransferase
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
dihydroorotasepyrCYESTIGR00856 (HMM): dihydroorotase, homodimeric type
TIGR00857 (HMM): dihydroorotase, multifunctional complex type
TIGR00856 (HMM): dihydroorotase, homodimeric type
TIGR00857 (HMM): dihydroorotase, multifunctional complex type
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
dihydroorotasepyrCYESTIGR00856 (HMM): dihydroorotase, homodimeric type
TIGR00857 (HMM): dihydroorotase, multifunctional complex type
TIGR00856 (HMM): dihydroorotase, homodimeric type
TIGR00857 (HMM): dihydroorotase, multifunctional complex type
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
dihydroorotasepyrCYESTIGR00856 (HMM): dihydroorotase, homodimeric type
TIGR00857 (HMM): dihydroorotase, multifunctional complex type
TIGR00856 (HMM): dihydroorotase, homodimeric type
TIGR00857 (HMM): dihydroorotase, multifunctional complex type
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
dihydroorotate dehydrogenasepyrDYESTIGR01036 (HMM): dihydroorotate dehydrogenase (fumarate)
TIGR01037 (HMM): dihydroorotate dehydrogenase family protein
PF01180 (HMM): dihydroorotate dehydrogenase
TIGR01036 (HMM): dihydroorotate dehydrogenase (fumarate)
TIGR01037 (HMM): dihydroorotate dehydrogenase family protein
PF01180 (HMM): dihydroorotate dehydrogenase
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
dihydroorotate dehydrogenasepyrDYESTIGR01036 (HMM): dihydroorotate dehydrogenase (fumarate)
TIGR01037 (HMM): dihydroorotate dehydrogenase family protein
PF01180 (HMM): dihydroorotate dehydrogenase
TIGR01036 (HMM): dihydroorotate dehydrogenase (fumarate)
TIGR01037 (HMM): dihydroorotate dehydrogenase family protein
PF01180 (HMM): dihydroorotate dehydrogenase
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
dihydroorotate dehydrogenasepyrDYESTIGR01036 (HMM): dihydroorotate dehydrogenase (fumarate)
TIGR01037 (HMM): dihydroorotate dehydrogenase family protein
PF01180 (HMM): dihydroorotate dehydrogenase
TIGR01036 (HMM): dihydroorotate dehydrogenase (fumarate)
TIGR01037 (HMM): dihydroorotate dehydrogenase family protein
PF01180 (HMM): dihydroorotate dehydrogenase
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
orotate phosphoribosyltransferasepyrEYESTIGR00336 (HMM): orotate phosphoribosyltransferase
TIGR01367 (HMM): orotate phosphoribosyltransferase
TIGR00336 (HMM): orotate phosphoribosyltransferase
TIGR01367 (HMM): orotate phosphoribosyltransferase
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
orotate phosphoribosyltransferasepyrEYESTIGR00336 (HMM): orotate phosphoribosyltransferase
TIGR01367 (HMM): orotate phosphoribosyltransferase
TIGR00336 (HMM): orotate phosphoribosyltransferase
TIGR01367 (HMM): orotate phosphoribosyltransferase
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
orotate phosphoribosyltransferasepyrEYESTIGR00336 (HMM): orotate phosphoribosyltransferase
TIGR01367 (HMM): orotate phosphoribosyltransferase
TIGR00336 (HMM): orotate phosphoribosyltransferase
TIGR01367 (HMM): orotate phosphoribosyltransferase
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
orotidine 5'-phosphate decarboxylasepyrFYESTIGR01740 (HMM): orotidine 5'-phosphate decarboxylase
TIGR02127 (HMM): orotidine 5'-phosphate decarboxylase
TIGR01740 (HMM): orotidine 5'-phosphate decarboxylase
TIGR02127 (HMM): orotidine 5'-phosphate decarboxylase
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
orotidine 5'-phosphate decarboxylasepyrFYESTIGR01740 (HMM): orotidine 5'-phosphate decarboxylase
TIGR02127 (HMM): orotidine 5'-phosphate decarboxylase
TIGR01740 (HMM): orotidine 5'-phosphate decarboxylase
TIGR02127 (HMM): orotidine 5'-phosphate decarboxylase
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
orotidine 5'-phosphate decarboxylasepyrFYESTIGR01740 (HMM): orotidine 5'-phosphate decarboxylase
TIGR02127 (HMM): orotidine 5'-phosphate decarboxylase
TIGR01740 (HMM): orotidine 5'-phosphate decarboxylase
TIGR02127 (HMM): orotidine 5'-phosphate decarboxylase
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
aspartate carbamoyltransferase, regulatory subunitpyrINOTIGR00240 (HMM): aspartate carbamoyltransferase, regulatory subunit
TIGR00240 (HMM): aspartate carbamoyltransferase, regulatory subunit
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
aspartate carbamoyltransferase, regulatory subunitpyrINOTIGR00240 (HMM): aspartate carbamoyltransferase, regulatory subunit
TIGR00240 (HMM): aspartate carbamoyltransferase, regulatory subunit
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process
aspartate carbamoyltransferase, regulatory subunitpyrINOTIGR00240 (HMM): aspartate carbamoyltransferase, regulatory subunit
TIGR00240 (HMM): aspartate carbamoyltransferase, regulatory subunit
GO:0006222: UMP biosynthetic process
GO:0006222: UMP biosynthetic process

Parent Properties
AccessionName
GenProp0185nucleotide biosynthesis
GenProp0185nucleotide biosynthesis
GenProp0185nucleotide biosynthesis


Sibling Properties
AccessionName
GenProp0110purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate
GenProp0673ribulose monophosphate pathway
GenProp0696xanthine utilization as a source of guanine-monophosphate (GMP)
GenProp0697guanine monophosphate (GMP) biosynthesis from inosine monophosphate (IMP)
GenProp0747adenosine monophosphate (AMP) biosynthesis from inosine monophosphate (IMP)