Genome Property Definition Page
Accession | GenProp0198 | |
Name | ruvABC Holliday junction complex | |
Type | SYSTEM | |
Description | RuvA, RuvB and RuvC proteins together act on Holliday junctions for homologous recombination and DNA repair. RuvAB is the branch migration complex and RuvC the resolvase. The system is strictly bacterial; proteins with little or no detectable sequence similarity process Holliday junctions in Archaea, eukaryotes, and some phage. A variety of Holliday junction-cleaving (Hjc) enzymes have been found in the Archaea (PMID:12382111). Holliday junction resolvases, including RuvC, Hjc and Hje, CCE1 (yeast) and A22R (poxviruses) are reviewed by Sharples (PMID:11251805). RuvC is replaced by RecU in firmicutes and mollicutes. | |
JCVI Role | DNA replication, recombination, and repair | |
Parent Property | GenProp0076: DNA handling GenProp0115: DNA repair GenProp0116: DNA metabolism | |
Literature References |
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Gene Ontology Term | GO:0000725: recombinational repair (biological_process) GO:0006310: DNA recombination (biological_process) |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
RuvA subunit, Holliday junction DNA helicase | ruvA | YES | TIGR00084 (HMM): Holliday junction DNA helicase RuvA | GO:0000725: recombinational repair GO:0006310: DNA recombination |
RuvB subunit, Holliday junction DNA helicase | ruvB | YES | TIGR00635 (HMM): Holliday junction DNA helicase RuvB | GO:0000725: recombinational repair GO:0006310: DNA recombination |
RuvC (or RecU) resolvase | ruvC | YES | TIGR00228 (HMM): crossover junction endodeoxyribonuclease RuvC TIGR00648 (HMM): recombination protein U | GO:0000725: recombinational repair GO:0006310: DNA recombination GO:0000725: recombinational repair GO:0006310: DNA recombination |
Parent Properties
Accession | Name |
---|---|
GenProp0076 | DNA handling |
GenProp0115 | DNA repair |
GenProp0116 | DNA metabolism |
Sibling Properties
Accession | Name |
---|---|
GenProp0018 | natural transformation |
GenProp0056 | type IV pilus |
GenProp0115 | DNA repair |
GenProp0311 | competence-related genes |
GenProp0489 | F-type conjugation system |
GenProp0490 | Ti-type conjugation system |
GenProp0699 | DNA gyrase |
GenProp0851 | integration host factor |
GenProp0855 | integrating conjugative element, PFGI-1 class |
GenProp0858 | conjugative transposon, Bacteroides type |
GenProp0114 | nucleotide excision repair |
GenProp0215 | SOS response |
GenProp0216 | recBCD pathway |
GenProp0224 | nucleotide excision repair, alternative pathway |
GenProp0225 | mismatch repair |
GenProp0227 | excision repair |
GenProp0228 | direct repair |
GenProp0491 | recFOR recombination pathway |
GenProp0492 | nonhomologous end-joining, bacterial type |
GenProp0493 | addAB pathway |
GenProp0767 | very short patch repair |
GenProp1099 | 8-oxoguanine DNA repair |
GenProp0263 | DNA polymerase III, bacterial |
GenProp0455 | restriction enzyme system, type I |
GenProp0487 | repABC-type alpha-proteobacterial replicon(s) |
GenProp0650 | type II restriction system, Alw26I/Eco31I/Esp3I family |
GenProp0701 | DNA sulfur modification system dnd |
GenProp0806 | replication initiation, bacterial |
GenProp0977 | DNA ligase/helicase system |
GenProp1081 | replication restart, PriA/PriB primosome pathway |
GenProp1095 | exodeoxyribonuclease VII |