Genome Property Definition Page

AccessionGenProp0201
NameSMC-ScpA-ScpB complex
TypeSYSTEM
DescriptionscpA and scpB (segregation and condensation) are proposed [1,2] to act with SMC (structural maintenance of chromosome). SMC is not universal, but is found in Eukaryotes, Archaea, and Bacteria. It is homodimeric in Archaea and Bacteria. A mutation study [2] has shown a role for scpA in DNA repair in addition to its role in chromosome condensation and segregation. Proteins that act with SMC may be termed kleisins; Different SMC/kleisin complexes are termed cohesins and condensins. ScpA and ScpB are clustered in most bacteria. SMC and scpA tend to be clustered in the archaea.
JCVI RoleCell division
Parent PropertyGenProp0167: cellular growth, organization and division
Literature References
[ 1 ]Soppa J, Kobayashi K, Noirot-Gros MF, Oesterhelt D, Ehrlich SD, Dervyn E, Ogasawara N, Moriya S.  Discovery of two novel families of proteins that are proposed to interact with prokaryotic SMC proteins, and characterization of the Bacillus subtilis family members ScpA and ScpB.  Mol Microbiol. 2002 Jul;45(1):59-71.  PMID 12100548
[ 2 ]Dervyn E, Noirot-Gros MF, Mervelet P, McGovern S, Ehrlich SD, Polard P, Noirot P.  The bacterial condensin/cohesin-like protein complex acts in DNA repair and regulation of gene expression.  Mol Microbiol. 2004 Mar;51(6):1629-40.  PMID 15009890
Gene Ontology TermGO:0000910: cytokinesis (biological_process)
GO:0007059: chromosome segregation (biological_process)
GO:0030261: chromosome condensation (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
smc proteinSMCYESTIGR02168 (HMM): chromosome segregation protein SMC
TIGR02169 (HMM): chromosome segregation protein SMC
GO:0030261: chromosome condensation
GO:0007059: chromosome segregation
GO:0000910: cytokinesis
GO:0030261: chromosome condensation
GO:0007059: chromosome segregation
GO:0000910: cytokinesis
ScpA proteinscpAYESPF02616 (HMM): ScpA/B proteinGO:0030261: chromosome condensation
GO:0007059: chromosome segregation
GO:0000910: cytokinesis
ScpB proteinscpBYESTIGR00281 (HMM): segregation and condensation protein BGO:0030261: chromosome condensation
GO:0007059: chromosome segregation
GO:0000910: cytokinesis

Parent Properties
AccessionName
GenProp0167cellular growth, organization and division


Sibling Properties
AccessionName
GenProp0049spore formation
GenProp0165minCDE system
GenProp0166mreBCD system
GenProp0173cell shape
GenProp0206bacterial cell division septum system
GenProp0296intracytoplasmic membranes
GenProp0460gas vesicle
GenProp0678c-type cytochrome biogenesis, system I
GenProp0680c-type cytochrome biogenesis, system II