Genome Property Definition Page

AccessionGenProp0211
NametmRNA trans-translation system
TypeSYSTEM
DescriptionDefective mRNA can lead to a stalled ribosome with no stop codon to release the mRNA and nascent polypeptide. A structural RNA called tmRNA (or SsrA), charged like a tRNA with an Ala, can restart stranslation. The tmRNA, while resembling a tRNA, contains a stretch that acts as mRNA with a short coding region and stop codon. The coding region encodes a 10-amino acid tag that marks the nascent protein, once released, for rapid degradation. Small protein B (SmpB) is required for tmRNA function and has no other known function.
JCVI RoleOther
Parent PropertyGenProp0197: protein biosynthesis
GenProp0301: protein degradation
GenProp0462: response to stress
GenProp0197: protein biosynthesis
GenProp0301: protein degradation
GenProp0462: response to stress
GenProp0197: protein biosynthesis
GenProp0301: protein degradation
GenProp0462: response to stress

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
tmRNA-binding protein SmpBSmpBYESTIGR00086 (HMM): SsrA-binding protein
TIGR00086 (HMM): SsrA-binding protein
tmRNA-binding protein SmpBSmpBYESTIGR00086 (HMM): SsrA-binding protein
TIGR00086 (HMM): SsrA-binding protein
tmRNA-binding protein SmpBSmpBYESTIGR00086 (HMM): SsrA-binding protein
TIGR00086 (HMM): SsrA-binding protein
SspB adaptor to clpXPsspBNOPF04386 (HMM): stringent starvation protein B
PF04386 (HMM): stringent starvation protein B
SspB adaptor to clpXPsspBNOPF04386 (HMM): stringent starvation protein B
PF04386 (HMM): stringent starvation protein B
SspB adaptor to clpXPsspBNOPF04386 (HMM): stringent starvation protein B
PF04386 (HMM): stringent starvation protein B
tmRNA structural RNAtmRNAYEStmRNA (RNA)

tmRNA (RNA)
tmRNA structural RNAtmRNAYEStmRNA (RNA)

tmRNA (RNA)
tmRNA structural RNAtmRNAYEStmRNA (RNA)

tmRNA (RNA)

Parent Properties
AccessionName
GenProp0197protein biosynthesis
GenProp0301protein degradation
GenProp0462response to stress
GenProp0197protein biosynthesis
GenProp0301protein degradation
GenProp0462response to stress
GenProp0197protein biosynthesis
GenProp0301protein degradation
GenProp0462response to stress


Sibling Properties
AccessionName
GenProp0016selenocysteine system
GenProp0312pyrrolysine
GenProp0132transcription termination - antitermination Nus factors
GenProp0148release factor 2 programmed frameshift
GenProp0174ribosome, bacterial, large subunit
GenProp0175ribosome, bacterial, small subunit
GenProp0188GatABC aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase complex
GenProp0189tRNA-Gln direct aminoacylation
GenProp0258tRNA aminoacylation
GenProp0259tRNA-Asn direct aminoacylation
GenProp0304cysteine biosynthesis, tRNA-dependent
GenProp0634Sigma-54 (RpoN) systems
GenProp0692selenouridine-containing tRNA
GenProp0704tRNA U34 carboxymethylaminomethyl modification
GenProp0740translation initiation, bacterial
GenProp0741translation elongation, bacterial
GenProp0746translation termination, bacterial
GenProp0812rho-dependent termination
GenProp0251clpXP degradation machine
GenProp0684FtsH/HflKC protease complex
GenProp0833proteasome-targeting modification by pupylation
GenProp0834proteasome, bacterial
GenProp0835ATP-dependent protease HslVU
GenProp04826S RNA (eubacterial RNA polymerase regulator)
GenProp0648phage shock protein regulon