Genome Property Definition Page

AccessionGenProp0216
NamerecBCD pathway
TypeSYSTEM
DescriptionThis property describes the presence of genes for the RecBCD protein complex, which participates in at least two different processes. As exodeoxyribonuclease V, it degrades linear double-stranded DNA, as might occur by cleavage of exogenous DNA by restriction systems. It also acts to repair double-stranded breaks in DNA by homologous recombination; genera that lack this complex tend to show stronger conservation of gene order between species. The RecBCD heterotrimer interacts with instances of the DNA sequence GCTGGTGG in E. coli, called Chi, which are recombinational hotspots. RecBCD promotes loading the strand exchange protein RecA onto chi-containing DNA. Double-stranded breaks are processed by AddAB rather than by RecBCD in the Firmicutes and in alpha-Proteobacteria.
JCVI RoleDNA replication, recombination, and repair
Parent PropertyGenProp0115: DNA repair
Literature References
[ 1 ]Nakamura Y, Nishio Y, Ikeo K, Gojobori T  The genome stability in Corynebacterium species due to lack of the recombinational repair system.  Gene 2003 Oct 23;317(1-2):149-55.  PMID 14604803
[ 2 ]Taylor AF, Smith GR  RecBCD enzyme is a DNA helicase with fast and slow motors of opposite polarity.  Nature 2003 Jun 19;423(6942):889-93.  PMID 12815437
Gene Ontology TermGO:0000725: recombinational repair (biological_process)
GO:0000738: DNA catabolic process, exonucleolytic (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
exodeoxyribonuclease V, beta subunitrecBYESTIGR00609 (HMM): exodeoxyribonuclease V, beta subunitGO:0000725: recombinational repair
GO:0000738: DNA catabolic process, exonucleolytic
exodeoxyribonuclease V, gamma subunitrecCYESTIGR01450 (HMM): exodeoxyribonuclease V, gamma subunitGO:0000725: recombinational repair
GO:0000738: DNA catabolic process, exonucleolytic
exodeoxyribonuclease V, alpha subunitrecDYESTIGR01447 (HMM): exodeoxyribonuclease V, alpha subunitGO:0000725: recombinational repair
GO:0000738: DNA catabolic process, exonucleolytic

Parent Properties
AccessionName
GenProp0115DNA repair


Sibling Properties
AccessionName
GenProp0114nucleotide excision repair
GenProp0198ruvABC Holliday junction complex
GenProp0215SOS response
GenProp0224nucleotide excision repair, alternative pathway
GenProp0225mismatch repair
GenProp0227excision repair
GenProp0228direct repair
GenProp0491recFOR recombination pathway
GenProp0492nonhomologous end-joining, bacterial type
GenProp0493addAB pathway
GenProp0767very short patch repair