Genome Property Definition Page

Accession

GenProp0217

Name

5-aminolevulinate biosynthesis (glutamate pathway)

Type

PATHWAY

Description

This pathway for the biosynthesis of 5-aminolevulinate, a porphyrin precursor, is known as the glutamate or C5 pathway and is found in most bacteria. A distinctive feature of this pathway is the utilization of an amino acid-charged tRNA as an enzymatic substrate. An alternative pathway from succinyl-CoA and glycine utilizing 5-aminolevulinate synthase is found in the alphaproteobacteria and eukaryotic mitochondria.

JCVI Role

Heme, porphyrin, and cobalamin

Parent Property

GenProp0255: 5-aminolevulinate biosynthesis

Literature References

[ 1 ]Moser J, Schubert WD, Heinz DW, Jahn D  Structure and function of glutamyl-tRNA reductase involved in 5-aminolaevulinic acid formation.  Biochem Soc Trans 2002 Aug;30(4):579-84.  PMID 12196141
[ 2 ]Oh-hama T  Evolutionary consideration on 5-aminolevulinate synthase in nature.  Orig Life Evol Biosph 1997 Aug;27(4):405-12.  PMID 9249985
[ 3 ]Hungerer C, Troup B, Romling U, Jahn D  Regulation of the hemA gene during 5-aminolevulinic acid formation in Pseudomonas aeruginosa.  J Bacteriol 1995 Mar;177(6):1435-43.  PMID 7883699

Web References

KEGG:Porphyrin and chlorophyll metabolism

Gene Ontology Term

GO:0006779: porphyrin-containing compound biosynthetic process (biological_process)

Components

Step Name	Step Num	Required	Evidence (Method)	Evidence Go Terms
APPARENT DISRUPTED READING FRAMES	DISRPT	NO	AUTHENTIC POINT MUTATION (MANUAL) TRUNCATION (MANUAL)	GO:0006779: porphyrin-containing compound biosynthetic process
glutamyl-tRNA synthetase	gltX	YES	TIGR00464 (HMM): glutamate--tRNA ligase TIGR00463 (HMM): glutamate--tRNA ligase	GO:0006779: porphyrin-containing compound biosynthetic process GO:0006779: porphyrin-containing compound biosynthetic process
glutamyl-tRNA reductase	hemA	YES	TIGR01035 (HMM): glutamyl-tRNA reductase	GO:0006779: porphyrin-containing compound biosynthetic process
glutamate-1-semialdehyde-2,1-aminomutase	hemL	YES	TIGR00713 (HMM): glutamate-1-semialdehyde-2,1-aminomutase	GO:0006779: porphyrin-containing compound biosynthetic process

Parent Properties

Accession	Name
GenProp0255	5-aminolevulinate biosynthesis

Sibling Properties

Accession	Name
GenProp0223	5-aminolevulinate biosynthesis from succinyl-CoA and glycine