Genome Property Definition Page

AccessionGenProp0220
Nameuroporhyrinogen III biosynthesis from 5-aminolevulinate
TypePATHWAY
DescriptionThis property describes the three step pathway that takes 5-aminolevulinate and converts it into uroporhyrinogen III, a compund which is used in the biosynthesis of siroheme, coenzyme B12, protoporphyrin IX and heme. Protoporphyrin IX is used in the creation of chlorophyll.
JCVI RoleHeme, porphyrin, and cobalamin
Parent PropertyGenProp0184: cofactor biosynthesis
GenProp0274: coenzyme B12 biosynthesis - overview
Gene Ontology TermGO:0006779: porphyrin-containing compound biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
Delta-aminolevulinic acid dehydratasehemBYESPF00490 (HMM): delta-aminolevulinic acid dehydrataseGO:0006779: porphyrin-containing compound biosynthetic process
porphobilinogen deaminasehemCYESTIGR00212 (HMM): hydroxymethylbilane synthaseGO:0006779: porphyrin-containing compound biosynthetic process
uroporphyrinogen-III synthasehemDYESPF02602 (HMM): uroporphyrinogen-III synthaseGO:0006779: porphyrin-containing compound biosynthetic process

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis
GenProp0113cobyrinic acid diamide biosynthesis, aerobic pathway
GenProp0269coenzyme B12 biosynthesis from cob(II)yrinate diamide
GenProp0275cobyrinic acid diamide biosynthesis, anaerobic pathway
GenProp0277cobalt import system (ABC transporter: 3.A.1.18.1)