Genome Property Definition Page

AccessionGenProp0221
Nameprotoporphyrin IX biosynthesis from uroporphyrinogen III
TypePATHWAY
DescriptionThis property describes a three step pathway that converts uroporphyrinogen III to protoporphyrin IX, a precursor to both protoheme (heme) and chlorophyll. Uroporphyrinogen III can be derived from 5-aminolevulinate, as described by GenProp0220.
JCVI RoleHeme, porphyrin, and cobalamin
Parent PropertyGenProp0184: cofactor biosynthesis
Gene Ontology TermGO:0006779: porphyrin-containing compound biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
uroporphyrinogen decarboxylasehemEYESTIGR01464 (HMM): uroporphyrinogen decarboxylaseGO:0006779: porphyrin-containing compound biosynthetic process
coproporphyrinogen III oxidasehemFYESPF01218 (HMM): coproporphyrinogen III oxidase, aerobic
TIGR00538 (HMM): oxygen-independent coproporphyrinogen III oxidase
GO:0006779: porphyrin-containing compound biosynthetic process
GO:0006779: porphyrin-containing compound biosynthetic process
protoporphyrinogen oxidasehemGYESTIGR00562 (HMM): protoporphyrinogen oxidaseGO:0006779: porphyrin-containing compound biosynthetic process

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis