Genome Property Definition Page

Namemismatch repair
DescriptionThe combination of MutS (the MutS1 branch but not the MutS2 branch of the MutS family) and MutL leads to a general mechanism for mismatch exision and repair (MMR). Other proteins, recruited by MutS1 and MutL, act to clip (MutH or other endonuclease), remove (UvrD), and resynthesize one strand in the region containing the mismatch. MMR constrasts in its generality with the targeting of specific mismatches by various base excision repair (BER) glycosylases and with variants of MMR that act on specific mismatches. In Escherichia coli and related species that contain the endonuclease MutH and the DNA adenine methylation protein Dam, lack of methylation marks the newly synthesized strand; the mismatch is resolved by excision, removal, and resynthesis of a piece of that strand. MMR is referred to as methyl-directed mismatch repair in this subset of species with MMR.
JCVI RoleDNA replication, recombination, and repair
Parent PropertyGenProp0115: DNA repair

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
MutH (or other) mismatch endonucleaseendonucNOTIGR02248 (HMM): DNA mismatch repair endonuclease MutH
DNA mismatch repair protein MutLmutLYESTIGR00585 (HMM): DNA mismatch repair protein MutL
DNA mismatch repair protein MutS (mutS1)mutS1YESTIGR01070 (HMM): DNA mismatch repair protein MutS

Parent Properties
GenProp0115DNA repair

Sibling Properties
GenProp0114nucleotide excision repair
GenProp0198ruvABC Holliday junction complex
GenProp0215SOS response
GenProp0216recBCD pathway
GenProp0224nucleotide excision repair, alternative pathway
GenProp0227excision repair
GenProp0228direct repair
GenProp0491recFOR recombination pathway
GenProp0492nonhomologous end-joining, bacterial type
GenProp0493addAB pathway
GenProp0767very short patch repair