Genome Property Definition Page

AccessionGenProp0231
Name4-hydroxyphenylacetate degradation
TypePATHWAY
Description4-hydroxyphenylacetic acid, a degradation product of tyrosine via one of several routes, of phenylalanine via phenylacetate, and of environmental DDT is metabolized in this pathway to the common metabolites succinate and pyruvate via homoprotocatechuate. 4-hydroxyphenylacetic acid may also be found in the environment and transported into the cell. The genes encoding the components of this pathway are often organized into apparent operons which include regulatory elements as well as a variety of transport systems. A number of genomes show partial evidence of the pathway based on homologs of the well-characterized enzymes from other species. Often, promising candidates for the missing steps are found in the vicinity. These are suggestive of enzymes which have been adapted from ancestral sequences having a different function. Of course, the possibility exists that it is the entire pathway that has been modified in these species and it is other structurally related compounds that are being metabolized instead of 4-hydroxyphenylacetic acid.
Parent PropertyGenProp0142: catabolism
Literature References
[ 1 ]Diaz E, Ferrandez A, Prieto MA, Garcia JL  Biodegradation of aromatic compounds by Escherichia coli.  Microbiol Mol Biol Rev 2001 Dec;65(4):523-69, table of contents.  PMID 11729263
Web ReferencesTyrosine metabolism - reference pathway
Gene Ontology TermGO:0009894: regulation of catabolic process (biological_process)
GO:0042537: benzene-containing compound metabolic process (biological_process)
GO:0046942: carboxylic acid transport (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
APPARENT DISRUPTED READING FRAMESDISRPTNOFRAMESHIFT (MANUAL)
succinate-semialdehyde dehydrogenaseSSDHYESTIGR01780 (HMM): succinate-semialdehyde dehydrogenase
regulatory protein, HpaAhpaANOTIGR02297 (HMM): 4-hydroxyphenylacetate catabolism regulatory protein HpaAGO:0009894: regulation of catabolic process
4-hydroxyphenylacetate 3-monooxygenase, large subunithpaBYESTIGR02309 (HMM): 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component
TIGR02310 (HMM): 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component
GO:0042537: benzene-containing compound metabolic process
GO:0042537: benzene-containing compound metabolic process
4-hydroxyphenylacetate 3-monooxygenase, small subunithpaCYESTIGR02296 (HMM): 4-hydroxyphenylacetate 3-monooxygenase, reductase componentGO:0042537: benzene-containing compound metabolic process
3,4-dihydroxyphenylacetate 2,3-dioxygenase (1.13.11.15)hpaDYESTIGR02295 (HMM): 3,4-dihydroxyphenylacetate 2,3-dioxygenase
TIGR02298 (HMM): 3,4-dihydroxyphenylacetate 2,3-dioxygenase
GO:0042537: benzene-containing compound metabolic process
GO:0042537: benzene-containing compound metabolic process
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase (1.2.1.60)hpaEYESTIGR02299 (HMM): 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseGO:0042537: benzene-containing compound metabolic process
5-carboxymethyl-2-hydroxymuconate delta-isomerase (5.3.3.10)hpaFYESPF02962 (HMM): 5-carboxymethyl-2-hydroxymuconate delta isomeraseGO:0042537: benzene-containing compound metabolic process
bifunctional decarboxylase/isomerase, C-terminalhpaG-CYESTIGR02303 (HMM): 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunitGO:0042537: benzene-containing compound metabolic process
bifunctional decarboxylase/isomerase, N-terminalhpaG-NYESTIGR02305 (HMM): 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunitGO:0042537: benzene-containing compound metabolic process
2-oxo-hepta-3-ene-1,7-dioate hydratasehpaHYESTIGR02312 (HMM): 2-oxo-hepta-3-ene-1,7-dioic acid hydrataseGO:0042537: benzene-containing compound metabolic process
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolasehpaIYESTIGR02311 (HMM): 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase
TIGR02313 (HMM): 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase
GO:0042537: benzene-containing compound metabolic process
GO:0042537: benzene-containing compound metabolic process
regulatory protein, HpaRhpaRNOTIGR02337 (HMM): homoprotocatechuate degradation operon regulator, HpaRGO:0009894: regulation of catabolic process
probable 4-hydroxyphenylacetate transporterstrnsprtNOTIGR02332 (HMM): 4-hydroxyphenylacetate permeaseGO:0046942: carboxylic acid transport

Parent Properties
AccessionName
GenProp0142catabolism


Sibling Properties
AccessionName
GenProp0055polyhydroxyalkanoic acids
GenProp0141galactose-6-phosphate degradation via tagatose-6-phosphate
GenProp0156cyanophycin-like storage polymers
GenProp0168glycogen system
GenProp0210phenylacetic acid catabolism
GenProp0233GABA utilization
GenProp02382-aminoethylphosphonate catabolism to acetaldehyde
GenProp0239propionyl-CoA catabolism
GenProp0241phosphonate catabolism
GenProp0271trehalose utilization
GenProp0272pyruvate fermentation to acetoin
GenProp0273protocatechuate degradation to beta-ketoadipate
GenProp0283beta-ketoadipate degradation to succinyl-CoA and acetyl-CoA
GenProp0294ethanolamine catabolism to acetaldehyde
GenProp0457rhamnose catabolism
GenProp0458fucose catabolism
GenProp0461utilization of deoxynucleosides
GenProp0653ectoine catabolism
GenProp0674malonate decarboxylase
GenProp0686allantoin catabolism to glyoxalate and urea
GenProp0687allantoin catabolism to oxamate and carbamoyl-phosphate
GenProp0688urate catabolism to allantoin
GenProp0691glycolysis
GenProp0693fructose utilization as fructose-1,6-bisphosphate
GenProp0694glucose utilization as fructose-1,6-bisphosphate
GenProp0700purine catabolism via urate, xanthine and allantoin
GenProp0702benzoyl-CoA reductase
GenProp07034-hydroxybenzoyl-CoA reductase
GenProp0706cyclohexa-1,5-diene-1-carbonyl-CoA to 3-hydroxypimelyl-CoA, dch/had/oah pathway
GenProp0708catechol meta-cleavage pathway
GenProp0709benzoate catabolism BoxABC pathway
GenProp0711catechol ortho-cleavage upper pathway
GenProp0714galactarate utilization via tartronate semi-aldehyde
GenProp0715galactarate utilization via 2-oxoglutarate semialdehyde
GenProp0716glucarate utilization via tartronate semi-aldehyde
GenProp0717glucarate utilization via 2-oxoglutarate semialdehyde
GenProp0718oxalate degradation
GenProp0734amino acid catabolism
GenProp0749choline sulfate utilization
GenProp0760putrescine degradation to GABA via gamma-glutamylation
GenProp0763nicotinate fermentation to pyruvate and propionate
GenProp0813pyrimidine utilization operon, RutABCDEFGR
GenProp0902quinohemoprotein amine dehydrogenase
GenProp1071myo-inositol catabolism
GenProp1072cyanase system
GenProp1076choline TMA-lyase system