Genome Property Definition Page

NameclpXP degradation machine
DescriptionThis property describes an energy-dependent protease, one of whose tasks is degradation of abortively translated proteins tagged by the tmRNA trans-translation system. ClpX is an ATPase that unfolds target proteins for degradation; ClpP is a protease in complex with ClpX. SspB is an example of an adaptor that brings targets, including but not restricted to proteins tagged by trans-translation, to the ClpXP machine.
JCVI RoleDegradation of proteins, peptides, and glycopeptides
Parent PropertyGenProp0301: protein degradation

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
adaptor SspBSspBNOPF04386 (HMM): stringent starvation protein B
temp clpAclpANOTIGR02639 (HMM): ATP-dependent Clp protease ATP-binding subunit ClpA
Clp protease proteolytic subunit ClpPclpPYESTIGR00493 (HMM): ATP-dependent Clp endopeptidase, proteolytic subunit ClpP
temp clpSclpSNOPF02617 (HMM): ATP-dependent Clp protease adaptor protein ClpS
Clp protease ATP-binding subunit ClpXclpXYESTIGR00382 (HMM): ATP-dependent Clp protease, ATP-binding subunit ClpX

Parent Properties
GenProp0301protein degradation

Sibling Properties
GenProp0211tmRNA trans-translation system
GenProp0684FtsH/HflKC protease complex
GenProp0833proteasome-targeting modification by pupylation
GenProp0834proteasome, bacterial
GenProp0835ATP-dependent protease HslVU