Genome Property Definition Page
| Accession | GenProp0251 |
| Name | clpXP degradation machine |
| Type | SYSTEM |
| Description | This property describes an energy-dependent protease, one of whose tasks is degradation of abortively translated proteins tagged by the tmRNA trans-translation system. ClpX is an ATPase that unfolds target proteins for degradation; ClpP is a protease in complex with ClpX. SspB is an example of an adaptor that brings targets, including but not restricted to proteins tagged by trans-translation, to the ClpXP machine. |
| JCVI Role | Degradation of proteins, peptides, and glycopeptides |
| Parent Property | GenProp0301: protein degradation |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| adaptor SspB | SspB | NO | PF04386 (HMM): stringent starvation protein B | |
| temp clpA | clpA | NO | TIGR02639 (HMM): ATP-dependent Clp protease ATP-binding subunit ClpA | |
| Clp protease proteolytic subunit ClpP | clpP | YES | TIGR00493 (HMM): ATP-dependent Clp endopeptidase, proteolytic subunit ClpP | |
| temp clpS | clpS | NO | PF02617 (HMM): ATP-dependent Clp protease adaptor protein ClpS | |
| Clp protease ATP-binding subunit ClpX | clpX | YES | TIGR00382 (HMM): ATP-dependent Clp protease, ATP-binding subunit ClpX |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0301 | protein degradation |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0211 | tmRNA trans-translation system |
| GenProp0684 | FtsH/HflKC protease complex |
| GenProp0833 | proteasome-targeting modification by pupylation |
| GenProp0834 | proteasome, bacterial |
| GenProp0835 | ATP-dependent protease HslVU |