Genome Property Definition Page
Accession | GenProp0251 |
Name | clpXP degradation machine |
Type | SYSTEM |
Description | This property describes an energy-dependent protease, one of whose tasks is degradation of abortively translated proteins tagged by the tmRNA trans-translation system. ClpX is an ATPase that unfolds target proteins for degradation; ClpP is a protease in complex with ClpX. SspB is an example of an adaptor that brings targets, including but not restricted to proteins tagged by trans-translation, to the ClpXP machine. |
JCVI Role | Degradation of proteins, peptides, and glycopeptides |
Parent Property | GenProp0301: protein degradation |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
adaptor SspB | SspB | NO | PF04386 (HMM): stringent starvation protein B | |
temp clpA | clpA | NO | TIGR02639 (HMM): ATP-dependent Clp protease ATP-binding subunit ClpA | |
Clp protease proteolytic subunit ClpP | clpP | YES | TIGR00493 (HMM): ATP-dependent Clp endopeptidase, proteolytic subunit ClpP | |
temp clpS | clpS | NO | PF02617 (HMM): ATP-dependent Clp protease adaptor protein ClpS | |
Clp protease ATP-binding subunit ClpX | clpX | YES | TIGR00382 (HMM): ATP-dependent Clp protease, ATP-binding subunit ClpX |
Parent Properties
Accession | Name |
---|---|
GenProp0301 | protein degradation |
Sibling Properties
Accession | Name |
---|---|
GenProp0211 | tmRNA trans-translation system |
GenProp0684 | FtsH/HflKC protease complex |
GenProp0833 | proteasome-targeting modification by pupylation |
GenProp0834 | proteasome, bacterial |
GenProp0835 | ATP-dependent protease HslVU |