Genome Property Definition Page

Namethiamine: TPP from HMP-PP and HET-P
DescriptionHydroxymethylpyrimidine pyrophosphate (HMP-PP) may be obtained de novo from a purine biosynthesis intermediate or by import or salvage, then phosphorylation, of hydroxymethylpyrimidine. Likewise, hydroxyethylthiazole phosphate may be come from synthesis, import, or salvage. The two heterocylic compounds are ligated by ThiE to thiamine phosphate. Thiamine phosphate then undegoes either dephosphorylation followed by pyrophosphorylation or direct phosphorylation. This property includes both ligation and remaining steps to obtain TPP.
JCVI RoleThiamine
Parent PropertyGenProp0261: thiamin pyrophosphate (TPP) de novo biosynthesis
Gene Ontology TermGO:0009228: thiamine biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
thiamine-phosphate diphosphorylaseThiEYESTIGR00693 (HMM): thiamine-phosphate diphosphorylaseGO:0009228: thiamine biosynthetic process
TPP riboswitch (THI element)riboswchNOTHI (RNA)
ThiL or pyrophosphokinasetoTPPYESTIGR01379 (HMM): thiamine-phosphate kinase
TIGR01378 (HMM): thiamine pyrophosphokinase
GO:0009228: thiamine biosynthetic process
GO:0009228: thiamine biosynthetic process

Parent Properties
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis

Sibling Properties
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp0253thiamine: hydroxymethylpyrimidine pyrophosphate from aminoimidazole ribotide