Genome Property Definition Page

AccessionGenProp0255
Name5-aminolevulinate biosynthesis
TypeMETAPATH
Description5-aminolevulinate, a heme precursor, may be biosynthesized by one of two pathways. The C5 (or Glutamate) pathway is more common (GenProp0217) while the alphaproteobacteria utilize the enzyme 5-aminolevulinate synthase to make the molecule from succinyl-CoA and glycine (GenProp0223). This property summarizes the other two, holding a YES state when either of the other two are found to be present.
JCVI RoleHeme, porphyrin, and cobalamin
Parent PropertyGenProp0184: cofactor biosynthesis
Gene Ontology TermGO:0006783: heme biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
5-aminolevulinate biosynthesis pathway5aminoYESGenProp0217 (GENPROP): 5-aminolevulinate biosynthesis (glutamate pathway)
GenProp0223 (GENPROP): 5-aminolevulinate biosynthesis from succinyl-CoA and glycine
GO:0006783: heme biosynthetic process
GO:0006783: heme biosynthetic process

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis

Child Properties
AccessionName
GenProp02175-aminolevulinate biosynthesis (glutamate pathway)
GenProp02235-aminolevulinate biosynthesis from succinyl-CoA and glycine

Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis