Genome Property Definition Page

AccessionGenProp0262
NameRNA polymerase, bacterial
TypeSYSTEM
DescriptionThis property describes the bacterial multisubunit DNA-directed RNA polymerase (EC 2.7.7.6). This property does not include sigma factors (at present), which are regulatory and varied, and so by definition describes the core enzyme rather than the holoenzyme. Subunit stochiometry is two alpha subunits to one each of beta and beta'. In Cyanobacteria and plastids, beta' is replaced by two proteins, one like the N-term of beta' (called gamma in Cyanobacteria and, confusingly, beta' in plastids) and one like the C-term of beta' (called beta' in Cyanobacteria and beta'' in plastids).
JCVI RoleDNA-dependent RNA polymerase
Parent PropertyGenProp0819: RNA metabolism
Literature References
[ 1 ]Seo PS, Yokota A  The phylogenetic relationships of cyanobacteria inferred from 16S rRNA, gyrB, rpoC1 and rpoD1 gene sequences.  J Gen Appl Microbiol 2003 Jun;49(3):191-203.  PMID 12949700
[ 2 ]Kojima I, Kasuga K, Kobayashi M, Fukasawa A, Mizuno S, Arisawa A, Akagawa H  The rpoZ gene, encoding the RNA polymerase omega subunit, is required for antibiotic production and morphological differentiation in Streptomyces kasugaensis.  J Bacteriol 2002 Dec;184(23):6417-23.  PMID 12426327
Web ReferencesKEGG: RNA polymerase

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
APPARENT DISRUPTED READING FRAMESDISRPTNOFRAMESHIFT (MANUAL)
RNA polymerase deltarnaPdltNOPF05066 (HMM): HB1/ASXL restriction endonuclease HTH domain
RNA polymerase alpharpoAYESTIGR02027 (HMM): DNA-directed RNA polymerase, alpha subunit
RNA polymerase betarpoBYESTIGR02013 (HMM): DNA-directed RNA polymerase, beta subunit
RNA polymerase beta', C-terminal regionrpoC_CYESTIGR02388 (HMM): DNA-directed RNA polymerase, beta'' subunit
TIGR02386 (HMM): DNA-directed RNA polymerase, beta' subunit
RNA polymerase beta', C-terminalrpoC_NYESTIGR02387 (HMM): DNA-directed RNA polymerase, gamma subunit
TIGR02386 (HMM): DNA-directed RNA polymerase, beta' subunit
RNA polymerase omegarpoZNOTIGR00690 (HMM): DNA-directed RNA polymerase, omega subunit

Parent Properties
AccessionName
GenProp0819RNA metabolism


Sibling Properties
AccessionName
GenProp0258tRNA aminoacylation
GenProp04826S RNA (eubacterial RNA polymerase regulator)
GenProp0677queuosine (Q-tRNA) biosynthesis from preQ0
GenProp0692selenouridine-containing tRNA
GenProp0704tRNA U34 carboxymethylaminomethyl modification
GenProp0898RNA ligase/unknown protein pair
GenProp0948RNA repair, Hen1/Pnkp system
GenProp1060tRNA N6-threonylcarbamoyladenosine modification
GenProp1077tRNA(Pro) cmo5UGG modification
GenProp108216S rRNA C1402 m(4)Cm modification