Genome Property Definition Page

AccessionGenProp0263
NameDNA polymerase III, bacterial
TypeSYSTEM
DescriptionThis property represents bacterial DNA polymerase III, a multisubunit replicative enzyme. In addition to core subunits, various bacteria may have accessory proteins that confer special properties such as greater speed and processivity. The single subunit in Gram-positive bacteria that carries polymerase and 3'-5' proofreading exonuclease activities corresponds to separate alpha (dnaE) and epsilon (dnaQ) subunits in E. coli. The polymerase works together with a clamp (beta, dnaN) and a clamp-loading complex of delta, delta-prime, and tau. In some species, a gamma subunit is related to tau by a translational frameshift from the same gene, dnaX. Some known accessory subunits include chi, psi, and theta.
JCVI RoleDNA replication, recombination, and repair
Parent PropertyGenProp0116: DNA metabolism
Literature References
[ 1 ]Song MS, Pham PT, Olson M, Carter JR, Franden MA, Schaaper RM, McHenry CS  The delta and delta ' subunits of the DNA polymerase III holoenzyme are essential for initiation complex formation and processive elongation.  J Biol Chem. 2001 Sep 14;276(37):35165-75. Epub 2001 Jun 29.  PMID 11432857
[ 2 ]Bruck I, O'Donnell M  The DNA replication machine of a gram-positive organism.  J Biol Chem. 2000 Sep 15;275(37):28971-83.  PMID 10878011

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
DNA polymerase III, alpha subunit (DnaE)dnaEYESTIGR00594 (HMM): DNA polymerase III, alpha subunit
DNA polymerase III, beta subunit (dnaN)dnaNYESTIGR00663 (HMM): DNA polymerase III, beta subunit
DNA polymerase III, epsilon subunit (dnaQ)dnaQYESTIGR01406 (HMM): DNA polymerase III, epsilon subunit
DNA polymerase III, gamma and tau subunits (dnaX)dnaXYESTIGR02397 (HMM): DNA polymerase III, subunit gamma and tau
DNA polymerase III, delta subunitholAYESTIGR01128 (HMM): DNA polymerase III, delta subunit
DNA polymerase III, delta prime subunitholBYESTIGR00678 (HMM): DNA polymerase III, delta' subunit
DNA polymerase III, chi subunit (holC)holCYESPF04364 (HMM): DNA polymerase III, chi subunit
DNA polymerase III, psi subunit (holD)holDYESTIGR00664 (HMM): DNA polymerase III, psi subunit
DNA polymerase III, theta subunit (holE)holENOPF06440 (HMM): DNA polymerase III, theta subunit
DNA polymerase III, alpha subunit, PolC-typepolCNOTIGR01405 (HMM): DNA polymerase III, alpha subunit, Gram-positive type

Parent Properties
AccessionName
GenProp0116DNA metabolism


Sibling Properties
AccessionName
GenProp0115DNA repair
GenProp0198ruvABC Holliday junction complex
GenProp0455restriction enzyme system, type I
GenProp0487repABC-type alpha-proteobacterial replicon(s)
GenProp0650type II restriction system, Alw26I/Eco31I/Esp3I family
GenProp0701DNA sulfur modification system dnd
GenProp0806replication initiation, bacterial
GenProp0977DNA ligase/helicase system
GenProp1081replication restart, PriA/PriB primosome pathway
GenProp1095exodeoxyribonuclease VII