Genome Property Definition Page

Nameectoine biosynthesis
DescriptionEctoine is a compatible solute used as an osmoprotectant by a number of bacterial species, including Vibrio cholerae, Halomonas variabilis, Bacillus pasteurii, Mycobacterium smegmatis, etc. Key enzymes are diaminobutyric acid acetyltransferase (EctA), diaminobutyric acid aminotransferase (EctB), and ectoine synthase (EctC). Ectoine is 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid. Many ectoine-producing species contain the enzyme ectoine hydroxylase (EctD), and also produce hydroxyectoine.
Parent PropertyGenProp0267: osmolyte biosynthesis
Literature References
[ 1 ]Kuhlmann AU, Bremer E  Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.  Appl Environ Microbiol 2002 Feb;68(2):772-83.  PMID 11823218
[ 2 ]Ofer N, Wishkautzan M, Meijler M, Wang Y, Speer A, Niederweis M, Gur E  Ectoine biosynthesis in Mycobacterium smegmatis.  Appl Environ Microbiol. 2012 Oct;78(20):7483-6.  PMID 22885758
Gene Ontology TermGO:0019491: ectoine biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
diaminobutyrate acetyltransferaseectAYESTIGR02406 (HMM): diaminobutyrate acetyltransferaseGO:0019491: ectoine biosynthetic process
diaminobutyrate--2-oxoglutarate transaminaseectBYESTIGR02407 (HMM): diaminobutyrate--2-oxoglutarate aminotransferaseGO:0019491: ectoine biosynthetic process
ectoine synthaseectCYESPF06339 (HMM): ectoine synthaseGO:0019491: ectoine biosynthetic process
ectoine hydroxylaseectDNOTIGR02408 (HMM): ectoine hydroxylase

Parent Properties
GenProp0267osmolyte biosynthesis

Sibling Properties
GenProp0147glycine betaine biosynthesis from choline
GenProp0264glucosylglycerol biosynthesis
GenProp0265trehalose biosynthesis, OtsAB pathway
GenProp0266trehalose biosynthesis, TreYZ pathway
GenProp0281mannosylglycerate biosynthesis
GenProp0878N(epsilon)-acetyl-beta-lysine biosynthesis
GenProp1070beta-glutamate biosynthesis