Genome Property Definition Page

AccessionGenProp0268
Nameectoine biosynthesis
TypePATHWAY
DescriptionEctoine is a compatible solute used as an osmoprotectant by a number of bacterial species, including Vibrio cholerae, Halomonas variabilis, Bacillus pasteurii, Mycobacterium smegmatis, etc. Key enzymes are diaminobutyric acid acetyltransferase (EctA), diaminobutyric acid aminotransferase (EctB), and ectoine synthase (EctC). Ectoine is 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid. Many ectoine-producing species contain the enzyme ectoine hydroxylase (EctD), and also produce hydroxyectoine.
Parent PropertyGenProp0267: osmolyte biosynthesis
GenProp0267: osmolyte biosynthesis
GenProp0267: osmolyte biosynthesis
Literature References
[ 1 ]Kuhlmann AU, Bremer E  Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.  Appl Environ Microbiol 2002 Feb;68(2):772-83.  PMID 11823218
[ 2 ]Ofer N, Wishkautzan M, Meijler M, Wang Y, Speer A, Niederweis M, Gur E  Ectoine biosynthesis in Mycobacterium smegmatis.  Appl Environ Microbiol. 2012 Oct;78(20):7483-6.  PMID 22885758
[ 1 ]Kuhlmann AU, Bremer E  Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.  Appl Environ Microbiol 2002 Feb;68(2):772-83.  PMID 11823218
[ 2 ]Ofer N, Wishkautzan M, Meijler M, Wang Y, Speer A, Niederweis M, Gur E  Ectoine biosynthesis in Mycobacterium smegmatis.  Appl Environ Microbiol. 2012 Oct;78(20):7483-6.  PMID 22885758
[ 1 ]Kuhlmann AU, Bremer E  Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.  Appl Environ Microbiol 2002 Feb;68(2):772-83.  PMID 11823218
[ 2 ]Ofer N, Wishkautzan M, Meijler M, Wang Y, Speer A, Niederweis M, Gur E  Ectoine biosynthesis in Mycobacterium smegmatis.  Appl Environ Microbiol. 2012 Oct;78(20):7483-6.  PMID 22885758
Gene Ontology TermGO:0019491: ectoine biosynthetic process (biological_process)
GO:0019491: ectoine biosynthetic process (biological_process)
GO:0019491: ectoine biosynthetic process (biological_process)
GO:0019491: ectoine biosynthetic process (biological_process)
GO:0019491: ectoine biosynthetic process (biological_process)
GO:0019491: ectoine biosynthetic process (biological_process)
GO:0019491: ectoine biosynthetic process (biological_process)
GO:0019491: ectoine biosynthetic process (biological_process)
GO:0019491: ectoine biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
diaminobutyrate acetyltransferaseectAYESTIGR02406 (HMM): diaminobutyrate acetyltransferase
TIGR02406 (HMM): diaminobutyrate acetyltransferase
GO:0019491: ectoine biosynthetic process
GO:0019491: ectoine biosynthetic process
diaminobutyrate acetyltransferaseectAYESTIGR02406 (HMM): diaminobutyrate acetyltransferase
TIGR02406 (HMM): diaminobutyrate acetyltransferase
GO:0019491: ectoine biosynthetic process
GO:0019491: ectoine biosynthetic process
diaminobutyrate acetyltransferaseectAYESTIGR02406 (HMM): diaminobutyrate acetyltransferase
TIGR02406 (HMM): diaminobutyrate acetyltransferase
GO:0019491: ectoine biosynthetic process
GO:0019491: ectoine biosynthetic process
diaminobutyrate--2-oxoglutarate transaminaseectBYESTIGR02407 (HMM): diaminobutyrate--2-oxoglutarate aminotransferase
TIGR02407 (HMM): diaminobutyrate--2-oxoglutarate aminotransferase
GO:0019491: ectoine biosynthetic process
GO:0019491: ectoine biosynthetic process
diaminobutyrate--2-oxoglutarate transaminaseectBYESTIGR02407 (HMM): diaminobutyrate--2-oxoglutarate aminotransferase
TIGR02407 (HMM): diaminobutyrate--2-oxoglutarate aminotransferase
GO:0019491: ectoine biosynthetic process
GO:0019491: ectoine biosynthetic process
diaminobutyrate--2-oxoglutarate transaminaseectBYESTIGR02407 (HMM): diaminobutyrate--2-oxoglutarate aminotransferase
TIGR02407 (HMM): diaminobutyrate--2-oxoglutarate aminotransferase
GO:0019491: ectoine biosynthetic process
GO:0019491: ectoine biosynthetic process
ectoine synthaseectCYESPF06339 (HMM): ectoine synthase
PF06339 (HMM): ectoine synthase
GO:0019491: ectoine biosynthetic process
GO:0019491: ectoine biosynthetic process
ectoine synthaseectCYESPF06339 (HMM): ectoine synthase
PF06339 (HMM): ectoine synthase
GO:0019491: ectoine biosynthetic process
GO:0019491: ectoine biosynthetic process
ectoine synthaseectCYESPF06339 (HMM): ectoine synthase
PF06339 (HMM): ectoine synthase
GO:0019491: ectoine biosynthetic process
GO:0019491: ectoine biosynthetic process
ectoine hydroxylaseectDNOTIGR02408 (HMM): ectoine hydroxylase
TIGR02408 (HMM): ectoine hydroxylase
ectoine hydroxylaseectDNOTIGR02408 (HMM): ectoine hydroxylase
TIGR02408 (HMM): ectoine hydroxylase
ectoine hydroxylaseectDNOTIGR02408 (HMM): ectoine hydroxylase
TIGR02408 (HMM): ectoine hydroxylase

Parent Properties
AccessionName
GenProp0267osmolyte biosynthesis
GenProp0267osmolyte biosynthesis
GenProp0267osmolyte biosynthesis


Sibling Properties
AccessionName
GenProp0147glycine betaine biosynthesis from choline
GenProp0264glucosylglycerol biosynthesis
GenProp0265trehalose biosynthesis, OtsAB pathway
GenProp0266trehalose biosynthesis, TreYZ pathway
GenProp0281mannosylglycerate biosynthesis
GenProp0878N(epsilon)-acetyl-beta-lysine biosynthesis
GenProp1070beta-glutamate biosynthesis