Genome Property Definition Page

AccessionGenProp0274
Namecoenzyme B12 biosynthesis - overview
TypeMETAPATH
DescriptionThis property summarizes and contains the various pathways and systems required for the complete biosynthesis of vitamin B12, 5-deoxyadenosyl cobalamin, from 5-aminolevulinate, S-adenosyl methionine, glutamine, cobalt, ATP, 1-amino-2-propanol, GDP, nicotinate mononucleotide and dimethylbenzimidazole.
Parent PropertyGenProp0184: cofactor biosynthesis

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go TermsBranch
Uroporphyrinogen III from 5-aminolevulinate: GenProp02201YESGenProp0220 (GENPROP): uroporhyrinogen III biosynthesis from 5-aminolevulinate
1
cobyrinic acid diamide biosynthesis, aerobic pathway: GenProp01132aYESGenProp0113 (GENPROP): cobyrinic acid diamide biosynthesis, aerobic pathway
aerobic
cobyrinic acid diamide biosynthesis, anaerobic pathway2bYESGenProp0275 (GENPROP): cobyrinic acid diamide biosynthesis, anaerobic pathway
anaerob
B12 from cob(II)yrinate diamide and alpha-ribazole: GenProp02694YESGenProp0269 (GENPROP): coenzyme B12 biosynthesis from cob(II)yrinate diamide
1
alpha-ribazole from nicotinate mononucleotide and dimethylbenzimidazole: GenProp02705NOGenProp0270 (GENPROP):
1
Cobalt import systems: GenProp02796YESGenProp0279 (GENPROP): cobalt import systems
1
cobalamin-utilizing enzymes: GenProp0284B12-enzYESGenProp0284 (GENPROP): cobalamin-utilizing enzymes
1

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis

Child Properties
AccessionName
GenProp0113cobyrinic acid diamide biosynthesis, aerobic pathway
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0269coenzyme B12 biosynthesis from cob(II)yrinate diamide
GenProp0275cobyrinic acid diamide biosynthesis, anaerobic pathway
GenProp0277cobalt import system (ABC transporter: 3.A.1.18.1)

Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis