Genome Property Definition Page

Namecobalt import system (CbtAB - proposed)
DescriptionThe pair of genes making up this property have been proposed to comprise a cobalt ion imorter for the biosynthesis of vitamin B12 (cobalamin). Evidence for this assignment includes 1) prediction of five trans-membrane segments in CbtA and a single additional trans-membrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site in CbtB, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localization of CbtA and CbtB.
Parent PropertyGenProp0279: cobalt import systems
Literature References
[ 1 ]Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS  Comparative genomics of the vitamin B12 metabolism and regulation in prokaryotes.  J Biol Chem 2003 Oct 17;278(42):41148-59. Epub 2003 Jul 17.  PMID 12869542

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
cobalt transporter subunit CbtACbtAYESTIGR02458 (HMM): cobalt transporter subunit CbtA (proposed)
cobalt transporter subunit CbtBCbtBYESTIGR02459 (HMM): cobalt transporter subunit CbtB (proposed)

Parent Properties
GenProp0279cobalt import systems

Sibling Properties
GenProp0277cobalt import system (ABC transporter: 3.A.1.18.1)