Genome Property Definition Page

Accession

GenProp0288

Name

tetrahydromethanopterin S-methyltransferase complex

Type

SYSTEM

Description

This complex of eight subunits, MtrA-H, effects the transfer of a methyl froup from tetrahydromethanopterin to coenzyme M using a cobalamin (B12) cofactor residing on MtrA. This transfer is coupled to an energy-driven sodium-ion pump. Methane is subsequently released by a two-electron reduction of the methyl-coenzyme M by the enzyme methyl-coenzyme M reductase.

Parent Property

GenProp0011: methanogenesis
GenProp0284: cobalamin-utilizing enzymes

Literature References

[ 1 ]Hippler B, Thauer RK The energy conserving methyltetrahydromethanopterin:coenzyme M methyltransferase complex from methanogenic archaea: function of the subunit MtrH. FEBS Lett 1999 Apr 23;449(2-3):165-8. PMID 10338124

Components

Step Name	Step Num	Required	Evidence (Method)
subunit A, cobalamin-containing	MtrA	YES	TIGR01111 (HMM): tetrahydromethanopterin S-methyltransferase, subunit A
	MtrB	YES	TIGR04166 (HMM): tetrahydromethanopterin S-methyltransferase, subunit B
	MtrC	YES	TIGR01148 (HMM): tetrahydromethanopterin S-methyltransferase, subunit C
	MtrD	YES	TIGR01112 (HMM): tetrahydromethanopterin S-methyltransferase, subunit D
	MtrE	YES	TIGR01113 (HMM): tetrahydromethanopterin S-methyltransferase, subunit E
	MtrF	YES	TIGR02507 (HMM): tetrahydromethanopterin S-methyltransferase, F subunit
	MtrG	YES	TIGR01149 (HMM): tetrahydromethanopterin S-methyltransferase, subunit G
subunit H, pterin:cobalamin transferase	MtrH	YES	TIGR01114 (HMM): N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit H

Parent Properties

Accession	Name
GenProp0011	methanogenesis
GenProp0284	cobalamin-utilizing enzymes

Sibling Properties

Accession	Name
GenProp0719	methyl-coenzyme M reductase
GenProp0722	methanogenesis marker set
GenProp0290	class II (B12-dependent) ribonucleotide reductase
GenProp0294	ethanolamine catabolism to acetaldehyde