Genome Property Definition Page

AccessionGenProp0290
Nameclass II (B12-dependent) ribonucleotide reductase
TypeSYSTEM
DescriptionRibonucleotide reductases (RNRs) are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. The class II RNRs consist of a single subunit and generate the required radical via an adenosylcobalamin (B12) cofactor. The most common gene symbols for this gene is NrdJ, although the gene in mycobacterium is called NrdZ. The first characterized NrdJ gene, from Lactobacillus leichmannii, acted specifically on nucleoside triphosphates like the class III enzymes (1.17.4.2) and unlike the class I enzymes which act on the diphosphates (1.17.4.1). However, as further B12-dependent RNRs were characterized, it became clear that this is the exception rather than the rule. This property captures both types.
JCVI Role2'-Deoxyribonucleotide metabolism
Parent PropertyGenProp0284: cobalamin-utilizing enzymes
GenProp0287: ribonucleotide reduction
Literature References
[ 1 ]Lawrence CC, Stubbe J  The function of adenosylcobalamin in the mechanism of ribonucleoside triphosphate reductase from Lactobacillus leichmannii.  Curr Opin Chem Biol 1998 Oct;2(5):650-5.  PMID 9818192
Gene Ontology TermGO:0009265: 2'-deoxyribonucleotide biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
B12-dependent ribonucleotide reductaseNrdJ/ZYESTIGR02505 (HMM): ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent
TIGR02504 (HMM): ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process

Parent Properties
AccessionName
GenProp0284cobalamin-utilizing enzymes
GenProp0287ribonucleotide reduction


Sibling Properties
AccessionName
GenProp0288tetrahydromethanopterin S-methyltransferase complex
GenProp0294ethanolamine catabolism to acetaldehyde
GenProp0289class I (aerobic) ribonucleotide reductase
GenProp0291class III (anaerobic) ribonucleotide reductase