Genome Property Definition Page

AccessionGenProp0291
Nameclass III (anaerobic) ribonucleotide reductase
TypeSYSTEM
DescriptionRibonucleotide reductases (RNRs) are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. The class III RNRs consist of two components, the catalytic enzyme (NrdD) and a radical-SAM domain enzyme (NrdG) which activates the catalytic enzyme by the generation of a protein-centered radical.
JCVI Role2'-Deoxyribonucleotide metabolism
Parent PropertyGenProp0287: ribonucleotide reduction
GenProp0287: ribonucleotide reduction
GenProp0287: ribonucleotide reduction
Literature References
[ 1 ]Fontecave M, Mulliez E, Logan DT  Deoxyribonucleotide synthesis in anaerobic microorganisms: the class III ribonucleotide reductase.  Prog Nucleic Acid Res Mol Biol 2002;72:95-127.  PMID 12206460
[ 1 ]Fontecave M, Mulliez E, Logan DT  Deoxyribonucleotide synthesis in anaerobic microorganisms: the class III ribonucleotide reductase.  Prog Nucleic Acid Res Mol Biol 2002;72:95-127.  PMID 12206460
[ 1 ]Fontecave M, Mulliez E, Logan DT  Deoxyribonucleotide synthesis in anaerobic microorganisms: the class III ribonucleotide reductase.  Prog Nucleic Acid Res Mol Biol 2002;72:95-127.  PMID 12206460
Gene Ontology TermGO:0009265: 2'-deoxyribonucleotide biosynthetic process (biological_process)
GO:0009265: 2'-deoxyribonucleotide biosynthetic process (biological_process)
GO:0009265: 2'-deoxyribonucleotide biosynthetic process (biological_process)
GO:0009265: 2'-deoxyribonucleotide biosynthetic process (biological_process)
GO:0009265: 2'-deoxyribonucleotide biosynthetic process (biological_process)
GO:0009265: 2'-deoxyribonucleotide biosynthetic process (biological_process)
GO:0009265: 2'-deoxyribonucleotide biosynthetic process (biological_process)
GO:0009265: 2'-deoxyribonucleotide biosynthetic process (biological_process)
GO:0009265: 2'-deoxyribonucleotide biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
anaerobic ribonucleoside-triphosphate reductaseNrdDYESTIGR02487 (HMM): anaerobic ribonucleoside-triphosphate reductase
TIGR02827 (HMM): anaerobic ribonucleoside-triphosphate reductase
TIGR02487 (HMM): anaerobic ribonucleoside-triphosphate reductase
TIGR02827 (HMM): anaerobic ribonucleoside-triphosphate reductase
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
anaerobic ribonucleoside-triphosphate reductaseNrdDYESTIGR02487 (HMM): anaerobic ribonucleoside-triphosphate reductase
TIGR02827 (HMM): anaerobic ribonucleoside-triphosphate reductase
TIGR02487 (HMM): anaerobic ribonucleoside-triphosphate reductase
TIGR02827 (HMM): anaerobic ribonucleoside-triphosphate reductase
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
anaerobic ribonucleoside-triphosphate reductaseNrdDYESTIGR02487 (HMM): anaerobic ribonucleoside-triphosphate reductase
TIGR02827 (HMM): anaerobic ribonucleoside-triphosphate reductase
TIGR02487 (HMM): anaerobic ribonucleoside-triphosphate reductase
TIGR02827 (HMM): anaerobic ribonucleoside-triphosphate reductase
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
activating protein for anaerobic ribonucleotide triphosphate reductaseNrdGYESTIGR02491 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
TIGR02495 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
TIGR02826 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
TIGR02491 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
TIGR02495 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
TIGR02826 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
activating protein for anaerobic ribonucleotide triphosphate reductaseNrdGYESTIGR02491 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
TIGR02495 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
TIGR02826 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
TIGR02491 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
TIGR02495 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
TIGR02826 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
activating protein for anaerobic ribonucleotide triphosphate reductaseNrdGYESTIGR02491 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
TIGR02495 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
TIGR02826 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
TIGR02491 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
TIGR02495 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
TIGR02826 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process

Parent Properties
AccessionName
GenProp0287ribonucleotide reduction
GenProp0287ribonucleotide reduction
GenProp0287ribonucleotide reduction


Sibling Properties
AccessionName
GenProp0289class I (aerobic) ribonucleotide reductase
GenProp0290class II (B12-dependent) ribonucleotide reductase