Genome Property Definition Page

Accession

GenProp0291

Name

class III (anaerobic) ribonucleotide reductase

Type

SYSTEM

Description

Ribonucleotide reductases (RNRs) are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. The class III RNRs consist of two components, the catalytic enzyme (NrdD) and a radical-SAM domain enzyme (NrdG) which activates the catalytic enzyme by the generation of a protein-centered radical.

JCVI Role

2'-Deoxyribonucleotide metabolism

Parent Property

GenProp0287: ribonucleotide reduction

Literature References

[ 1 ]Fontecave M, Mulliez E, Logan DT Deoxyribonucleotide synthesis in anaerobic microorganisms: the class III ribonucleotide reductase. Prog Nucleic Acid Res Mol Biol 2002;72:95-127. PMID 12206460

Gene Ontology Term

GO:0009265: 2'-deoxyribonucleotide biosynthetic process (biological_process)

Components

Step Name	Step Num	Required	Evidence (Method)	Evidence Go Terms
anaerobic ribonucleoside-triphosphate reductase	NrdD	YES	TIGR02487 (HMM): anaerobic ribonucleoside-triphosphate reductase TIGR02827 (HMM): anaerobic ribonucleoside-triphosphate reductase	GO:0009265: 2'-deoxyribonucleotide biosynthetic process GO:0009265: 2'-deoxyribonucleotide biosynthetic process
activating protein for anaerobic ribonucleotide triphosphate reductase	NrdG	YES	TIGR02491 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein TIGR02495 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein TIGR02826 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein	GO:0009265: 2'-deoxyribonucleotide biosynthetic process GO:0009265: 2'-deoxyribonucleotide biosynthetic process GO:0009265: 2'-deoxyribonucleotide biosynthetic process

Parent Properties

Accession	Name
GenProp0287	ribonucleotide reduction

Sibling Properties

Accession	Name
GenProp0289	class I (aerobic) ribonucleotide reductase
GenProp0290	class II (B12-dependent) ribonucleotide reductase