Genome Property Definition Page

AccessionGenProp0292
Nameethanolamine degradation organelle
TypeSYSTEM
DescriptionEthanolamine can be broken down to acetaldehyde by the action of ethanolamine ammonia lyase, an adenosyl cobalamin (vitamin B12) dependent enzyme. In its simplest form this system consists only of the two subunits of the enzyme, but ususally also includes a transporter for ethanolamine and may include a coexpressed acetaldehyde dehydrogenase to ensure that the toxic aldehyde is efficiently converted to acetyl-CoA. This property encompasses the more complex version of this system which includes additional genes coding for the proteinaceous coat of a specialized organelle as well as other genes for the efficienct maintenance and regulation of the lyase, handling of the product and import of the substrate. Presumably, this organellar system in organisms which may rely on ethanolamine as a primary carbon source.
Parent PropertyGenProp0294: ethanolamine catabolism to acetaldehyde
Literature References
[ 1 ]Faust LP, Babior BM  Overexpression, purification, and some properties of the AdoCbl-dependent ethanolamine ammonia-lyase from Salmonella typhimurium.  Arch Biochem Biophys 1992 Apr;294(1):50-4.  PMID 1550360
[ 2 ]Mori K, Bando R, Hieda N, Toraya T  Identification of a reactivating factor for adenosylcobalamin-dependent ethanolamine ammonia lyase.  J Bacteriol 2004 Oct;186(20):6845-54.  PMID 15466038
[ 3 ]Sheppard DE, Penrod JT, Bobik T, Kofoid E, Roth JR  Evidence that a B12-adenosyl transferase is encoded within the ethanolamine operon of Salmonella enterica.  J Bacteriol 2004 Nov;186(22):7635-44.  PMID 15516577
[ 4 ]Penrod JT, Mace CC, Roth JR  A pH-sensitive function and phenotype: evidence that EutH facilitates diffusion of uncharged ethanolamine in Salmonella enterica.  J Bacteriol 2004 Oct;186(20):6885-90.  PMID 15466042
[ 5 ]Huseby DL, Roth JR  Evidence that a metabolic microcompartment contains and recycles private cofactor pools.  J Bacteriol. 2013 Jun;195(12):2864-79. doi: 10.1128/JB.02179-12.  PMID 23585538
Web ReferencesGlycerophospholipid metabolism
Gene Ontology TermGO:0046336: ethanolamine catabolic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
phosphotransacetylasePtrnsAcNOPF01515 (HMM-CLUST): phosphate acetyl/butyryl transferaseGO:0046336: ethanolamine catabolic process
conserved hypothetical in ethanolamine operoneut-chpNOTIGR02536 (HMM): ethanolamine utilization proteinGO:0046336: ethanolamine catabolic process
reactivating factor for ethanolamine ammonia lyaseeutAYESPF06277 (HMM): ethanolamine utilization protein EutAGO:0046336: ethanolamine catabolic process
ethanolamine ammonia lyase, large subuniteutBYESPF06751 (HMM): ethanolamine ammonia-lyase, large subunitGO:0046336: ethanolamine catabolic process
ethanolamine ammonia lyase, small subuniteutCYESPF05985 (HMM): ethanolamine ammonia-lyase, light subunitGO:0046336: ethanolamine catabolic process
acetaldehyde dehydrogenase (acetylating)eutEYESTIGR02518 (HMM-CLUST): acetaldehyde dehydrogenase (acetylating)
PF00171 (HMM-CLUST): aldehyde dehydrogenase (NAD) family protein
PF00171 (NOCLUST): aldehyde dehydrogenase (NAD) family protein
GO:0046336: ethanolamine catabolic process
GO:0046336: ethanolamine catabolic process
GO:0046336: ethanolamine catabolic process
alcohol dehydrogenase, ethanolamine operon relatedeutGYESPF00465 (HMM-CLUST): alcohol dehydrogenase, iron-containingGO:0046336: ethanolamine catabolic process
ethanolamine permeaseeutHYESTIGR00908 (HMM): ethanolamine permease
PF04346 (HMM): ethanolamine utilisation protein EutH
GO:0046336: ethanolamine catabolic process
GO:0046336: ethanolamine catabolic process
ethanolamine utilization protein EutJeutJNOTIGR02529 (HMM): ethanolamine utilization protein EutJ family proteinGO:0046336: ethanolamine catabolic process
microcompartment coat proteineutMYESPF00936 (HMM-CLUST): BMC domainGO:0046336: ethanolamine catabolic process
carboxysome coat protein homologeutNYESPF03319 (HMM-CLUST): ethanolamine utilisation protein EutN/carboxysomeGO:0046336: ethanolamine catabolic process
ethanolamine utilization protein, EutPeutPNOTIGR02528 (HMM-CLUST): ethanolamine utilization protein, EutPGO:0046336: ethanolamine catabolic process
ethanolamine utilization protein, PduL homologeutPduLNOPF06130 (HMM-CLUST): propanediol utilization protein PduLGO:0046336: ethanolamine catabolic process
carboxysome coat protein homologeutPduTNOTIGR02526 (HMM): PduT-like ethanolamine utilization proteinGO:0046336: ethanolamine catabolic process
ethanolamine utilization protein, EutQeutQNOPF06249 (HMM-CLUST): ethanolamine utilization protein EutQGO:0046336: ethanolamine catabolic process
cob(I)alamin adenosyltransferaseeutTNOPF01923 (HMM-CLUST): putative ATP:cob(I)alamin adenosyltransferaseGO:0046336: ethanolamine catabolic process
regulatory componentsregulNOPF00007 (HMM-CLUST): cystine-knot domain
PF07568 (HMM-CLUST): histidine kinase
PF00072 (HMM-CLUST): response regulator receiver domain
PF00165 (HMM-CLUST): transcriptional regulator, AraC family
GO:0046336: ethanolamine catabolic process
GO:0046336: ethanolamine catabolic process
GO:0046336: ethanolamine catabolic process
GO:0046336: ethanolamine catabolic process

Parent Properties
AccessionName
GenProp0294ethanolamine catabolism to acetaldehyde