Genome Property Definition Page

Namecysteine biosynthesis, tRNA-dependent
DescriptionMethanocaldococcus jannaschii is a model archaeal species that lacks a direct cys--tRNA ligase. In a system analogous to pyrrolysine and (in many species) asparagine tRNA aminoacylation, the tRNA is misacylated and then the attached amino acid is modified. This two-step pathway is conducted by proteins in the families of MJ1660 (sepS) and MJ1678 (pscS). This pathway assumes 0-phosphoserine, whose biosynthesis is proposed to require D-3-phosphoglycerate dehydrogenase (TIGR01327) and an unidentified aminotransferase.
JCVI RoletRNA aminoacylation
Parent PropertyGenProp0126: amino acid biosynthesis
GenProp0197: protein biosynthesis
GenProp0305: cysteine biosynthesis
Literature References
[ 1 ]Sauerwald A, Zhu W, Major TA, Roy H, Palioura S, Jahn D, Whitman WB, Yates JR 3rd, Ibba M, Soll D  RNA-dependent cysteine biosynthesis in archaea.  Science 2005 Mar 25;307(5717):1969-72.  PMID 15790858
Gene Ontology TermGO:0019344: cysteine biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
Sep-tRNA:Cys-tRNA synthasepscSYESTIGR02539 (HMM): O-phospho-L-seryl-tRNA:Cys-tRNA synthaseGO:0019344: cysteine biosynthetic process
O-phosphoseryl-tRNA synthetasesepSYESTIGR00470 (HMM): O-phosphoserine--tRNA ligaseGO:0019344: cysteine biosynthetic process

Parent Properties
GenProp0126amino acid biosynthesis
GenProp0197protein biosynthesis
GenProp0305cysteine biosynthesis

Sibling Properties
GenProp0001chorismate biosynthesis via shikimate
GenProp0016selenocysteine system
GenProp0037tryptophan biosynthesis from ribose-5-phosphate
GenProp0039phenylalanine biosynthesis from chorismate
GenProp0045tyrosine biosynthesis from chorismate
GenProp0087arginine biosynthesis from glutatmate via N-acetylglutamate
GenProp0109histidine biosynthesis from ribose-5-phosphate
GenProp0111proline biosynthesis from glutamate
GenProp0117arginine biosynthesis from ornithine, carbamoyl-p and aspartate
GenProp0118ornithine biosynthesis from glutamate, acetylated branch
GenProp0159threonine biosynthesis from aspartate semialdehyde
GenProp0160aspartate semialdehyde biosynthesis from aspartate
GenProp0161methionine biosynthesis from homoserine
GenProp0162isoleucine biosynthesis from threonine and pyruvate
GenProp0163valine biosynthesis from pyruvate
GenProp0164leucine biosynthesis from pyruvate and acetyl-CoA
GenProp0178glycine cleavage system
GenProp0199lysine biosynthesis
GenProp0305cysteine biosynthesis
GenProp0729methionine salvage from methylthioadenosine
GenProp0797selenocysteinyl-tRNA, PSTK/SepSecS pathway
GenProp0132transcription termination - antitermination Nus factors
GenProp0148release factor 2 programmed frameshift
GenProp0174ribosome, bacterial, large subunit
GenProp0175ribosome, bacterial, small subunit
GenProp0188GatABC aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase complex
GenProp0189tRNA-Gln direct aminoacylation
GenProp0211tmRNA trans-translation system
GenProp0258tRNA aminoacylation
GenProp0259tRNA-Asn direct aminoacylation
GenProp0634Sigma-54 (RpoN) systems
GenProp0692selenouridine-containing tRNA
GenProp0704tRNA U34 carboxymethylaminomethyl modification
GenProp0740translation initiation, bacterial
GenProp0741translation elongation, bacterial
GenProp0746translation termination, bacterial
GenProp0812rho-dependent termination
GenProp0218cysteine biosynthesis from serine