Genome Property Definition Page

AccessionGenProp0314
NameCRISPR system, II/Nmeni subtype
TypeSYSTEM
DescriptionCRISPR repeats are by definition Clustered Regularly Interspaced Short Palindromic Repeats. The repeats vary in size from 24 to 48 bp, interspaced by similarly sized non-repetitive sequences. These spacers often are derived from phage and other exogenous DNA, are transcribed into RNA, and confer resistance to those same phage. Several CRISPR-associated sequences (cas genes) are nearly as widespread as CRISPR itself and nearly always are found near repeat loci. Others represent minor cas genes that serve as markers for specific subtypes of CRISPR/cas system, each with characteristic cas gene makeup, repeat structure, and spacer length. The Nmeni subtype, so named because this subtype is the only one found in the genome of Neisseria meningitidis, consists of cas1 and cas2 and the subtype specific genes csn1-2. This subtype has the most limited suite of cas core genes of any subtype defined thus far. The repeats associated with this subtype tend to have a periodicity of 66 nucleotides. This subtype is found only in Bacteria, and notably it would seem only in known or potential (i.e. containing virulence genes) vertebrate pathogens.
JCVI RoleOther
Parent PropertyGenProp0021: CRISPR region
Literature References
[ 1 ]Saunders NF, Goodchild A, Raftery M, Guilhaus M, Curmi PM, Cavicchioli R  Predicted roles for hypothetical proteins in the low-temperature expressed proteome of the Antarctic archaeon Methanococcoides burtonii.  J Proteome Res 2005 Mar-Apr;4(2):464-72.  PMID 15822923
[ 2 ]Haft DH, Selengut J, Mo ngodin EF, Nelson KE  A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes.  PLoS Comput Biol. 2005 Nov;1(6):e60.  PMID 16292354

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
Cas1, Nmeni regionCas1YESTIGR03639 (HMM): CRISPR-associated endonuclease Cas1, subtype II/NMENI
Cas2, Nmeni regionCas2YESTIGR01573 (HMM-CLUST): CRISPR-associated endonuclease Cas2
RNA-guided endonuclease Cas9/Csn1Cas9YESTIGR01865 (HMM): CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI
Csn2Csn2NOTIGR01866 (HMM): CRISPR type II-A/NMEMI-associated protein Csn2

Parent Properties
AccessionName
GenProp0021CRISPR region


Sibling Properties
AccessionName
GenProp0310CRISPR system, I-F/Ypest subtype
GenProp0313CRISPR system, I-C/Dvulg subtype
GenProp0315CRISPR system, I-E/Ecoli subtype
GenProp0316CRISPR system, III-B/RAMP module subtype
GenProp0317CRISPR system, I-B subtype, Tneap branch
GenProp0318CRISPR system, III-A/Mtube subtype
GenProp0319CRISPR system, I-A/Apern subtype
GenProp0320CRISPR system, I-B subtype, Hmari branch
GenProp0469CRISPR system, Dpsyc subtype
GenProp0670CRISPR system, Aferr subtype
GenProp0685CRISPR system, I-D/Cyano subtype
GenProp0768CRISPR system, Pging subtype
GenProp0922CRISPR system, Myxan subtype
GenProp1061CRISPR system, PreFran subtype