Genome Property Definition Page
Accession | GenProp0318 | |
Name | CRISPR system, III-A/Mtube subtype | |
Type | SYSTEM | |
Description | CRISPR repeats are by definition Clustered Regularly Interspaced Short Palindromic Repeats, described by Jansen [1]. Certain proteins, including Cas1 to Cas4, are found only in genomes with CRISPR repeats, and are near these repeats. Jansen, et al. describe CRISPR loci as having direct repeats, varying in size from 21 to 37 bp, interspaced by similarly sized non-repetitive sequences. Variants of CRISP/Cas loci (subtypes) have been described (Haft, Selengut, et al., submitted) in which certain groups of subtype-specific genes are found in addition to characteristic sets of the more widely distributed cas genes. The Mtube subtype, so named because this subtype is the only one found in the genome of Mycobacterium tuberculosis, consists of cas1, cas2, and the subtype specific genes csm1-5. Csm3, 4 and 5 are members of the RAMP superfamily, and this subtype shares some similarities with the CRISPR RAMP module in that it tends to be associated with other subtypes and often forms hybrid-subtype loci. | |
JCVI Role | Other | |
Parent Property | GenProp0021: CRISPR region | |
Literature References |
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Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
Cas1, Mtube region | Cas1 | YES | TIGR00287 (HMM-CLUST): CRISPR-associated endonuclease Cas1 | |
Cas2, Mtube region | Cas2 | YES | TIGR01573 (HMM-CLUST): CRISPR-associated endonuclease Cas2 | |
Cas6, Mtube region | Cas6 | YES | TIGR01877 (HMM-CLUST): CRISPR-associated endoribonuclease Cas6 | |
Csm1 | Csm1 | YES | TIGR02578 (HMM): CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE | |
Csm2 | Csm2 | YES | TIGR01870 (HMM): CRISPR type III-A/MTUBE-associated protein Csm2 | |
Csm3 | Csm3 | YES | TIGR02582 (HMM): CRISPR type III-A/MTUBE-associated RAMP protein Csm3 | |
Csm4 | Csm4 | YES | TIGR01903 (HMM): CRISPR type III-A/MTUBE-associated RAMP protein Csm4 | |
Csm5 | Csm5 | YES | TIGR01899 (HMM): CRISPR type III-A/MTUBE-associated RAMP protein Csm5 | |
Csm6 | Csm6 | NO | TIGR02672 (HMM): CRISPR type III-A/MTUBE-associated protein Csm6 |
Parent Properties
Accession | Name |
---|---|
GenProp0021 | CRISPR region |
Sibling Properties
Accession | Name |
---|---|
GenProp0310 | CRISPR system, I-F/Ypest subtype |
GenProp0313 | CRISPR system, I-C/Dvulg subtype |
GenProp0314 | CRISPR system, II/Nmeni subtype |
GenProp0315 | CRISPR system, I-E/Ecoli subtype |
GenProp0316 | CRISPR system, III-B/RAMP module subtype |
GenProp0317 | CRISPR system, I-B subtype, Tneap branch |
GenProp0319 | CRISPR system, I-A/Apern subtype |
GenProp0320 | CRISPR system, I-B subtype, Hmari branch |
GenProp0469 | CRISPR system, Dpsyc subtype |
GenProp0670 | CRISPR system, Aferr subtype |
GenProp0685 | CRISPR system, I-D/Cyano subtype |
GenProp0768 | CRISPR system, Pging subtype |
GenProp0922 | CRISPR system, Myxan subtype |
GenProp1061 | CRISPR system, PreFran subtype |