Genome Property Definition Page
Accession | GenProp0321 |
Name | toxin-antitoxin system, type II |
Type | GUILD |
Description | Pair of genes are often found to maintain plasmids by a mechanism of post-segregational killing. One protein is a short-lived antidote, the other a long-lived toxin, and the two encoded together. Loss of the gene pair, as from a cell division in which one of the daughter cells does not receive a copy of the plasmid, leads to loss of the antidote faster than the toxin, and therefore to cell death. Such pairs are called addition modules, and may be chromosomal rather than plasmid. Chromosomal pairs frequently have mRNA-cleaving activity with bacteriostatic rather than bacteriocidal activity, and may benefit the host cell by enabling a persister state in response to certain challenges. |
JCVI Role | Other |
Parent Property | GenProp0066: selfish genetic elements |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
antidote partner (various) | antidote | YES | TIGR01552 (HMM): prevent-host-death family protein PF02604 (HMM): antitoxin Phd/YefM, type II toxin-antitoxin system PF07362 (HMM): post-segregation antitoxin CcdA TIGR02384 (HMM): addiction module antitoxin, RelB/DinJ family PF04221 (HMM): RelB antitoxin PF03693 (HMM-CLUST): PF03693 family protein PF01381 (HMM-CLUST): DNA-binding helix-turn-helix protein TIGR02609 (HMM): putative addiction module antidote TIGR02607 (HMM): addiction module antidote protein, HigA family TIGR02606 (HMM): putative addiction module antidote protein, CC2985 family | |
killing partner | killing | YES | PF05016 (HMM): plasmid stabilization system protein, RelE/ParE family TIGR02116 (HMM): addiction module toxin, Txe/YoeB family TIGR02385 (HMM): addiction module toxin, RelE/StbE family TIGR00053 (HMM): addiction module toxin component, YafQ family PF01845 (HMM): CcdB protein PF05012 (HMM): PF05015 (HMM): plasmid maintenance system killer protein TIGR01550 (HMM): death-on-curing family protein PF03882 (HMM): KicB killing factor PF08085 (HMM): entericidin EcnA/B family PF02452 (HMM): PemK-like protein TIGR00305 (HMM): putative toxin-antitoxin system toxin component, PIN family PF05973 (HMM): Gp49-like PF05973 family | |
unassigned role in predicted module | unassign | NO | TIGR02574 (HMM): putative addiction module component, TIGR02574 family |
Parent Properties
Accession | Name |
---|---|
GenProp0066 | selfish genetic elements |
Child Properties
Accession | Name |
---|---|
GenProp0322 | addiction module, hig class |
GenProp0323 | addiction module, ParE class |
GenProp0324 | addiction module, RelE-RelB class |
GenProp0453 | uncharacterized gene pair TIGR02612/TIGR02613 |
Sibling Properties
Accession | Name |
---|---|
GenProp0009 | integrative genetic element |
GenProp0010 | inteins |
GenProp0024 | group I intron |
GenProp0025 | group II intron |
GenProp0050 | prophage regions |
GenProp0208 | phage: major features |
GenProp0226 | integron |
GenProp0476 | protein-coding palindromic elements |
GenProp1091 | toxin-antitoxin system, type I |
GenProp1092 | toxin-antitoxin system, type III |