Genome Property Definition Page

AccessionGenProp0321
Nametoxin-antitoxin system, type II
TypeGUILD
DescriptionPair of genes are often found to maintain plasmids by a mechanism of post-segregational killing. One protein is a short-lived antidote, the other a long-lived toxin, and the two encoded together. Loss of the gene pair, as from a cell division in which one of the daughter cells does not receive a copy of the plasmid, leads to loss of the antidote faster than the toxin, and therefore to cell death. Such pairs are called addition modules, and may be chromosomal rather than plasmid. Chromosomal pairs frequently have mRNA-cleaving activity with bacteriostatic rather than bacteriocidal activity, and may benefit the host cell by enabling a persister state in response to certain challenges.
JCVI RoleOther
Parent PropertyGenProp0066: selfish genetic elements
GenProp0066: selfish genetic elements
GenProp0066: selfish genetic elements

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
antidote partner (various)antidoteYESTIGR01552 (HMM): prevent-host-death family protein
PF02604 (HMM): antitoxin Phd/YefM, type II toxin-antitoxin system
PF07362 (HMM): post-segregation antitoxin CcdA
TIGR02384 (HMM): addiction module antitoxin, RelB/DinJ family
PF04221 (HMM): RelB antitoxin
PF03693 (HMM-CLUST): PF03693 family protein
PF01381 (HMM-CLUST): DNA-binding helix-turn-helix protein
TIGR02609 (HMM): putative addiction module antidote
TIGR02607 (HMM): addiction module antidote protein, HigA family
TIGR02606 (HMM): putative addiction module antidote protein, CC2985 family
TIGR01552 (HMM): prevent-host-death family protein
PF02604 (HMM): antitoxin Phd/YefM, type II toxin-antitoxin system
PF07362 (HMM): post-segregation antitoxin CcdA
TIGR02384 (HMM): addiction module antitoxin, RelB/DinJ family
PF04221 (HMM): RelB antitoxin
PF03693 (HMM-CLUST): PF03693 family protein
PF01381 (HMM-CLUST): DNA-binding helix-turn-helix protein
TIGR02609 (HMM): putative addiction module antidote
TIGR02607 (HMM): addiction module antidote protein, HigA family
TIGR02606 (HMM): putative addiction module antidote protein, CC2985 family
antidote partner (various)antidoteYESTIGR01552 (HMM): prevent-host-death family protein
PF02604 (HMM): antitoxin Phd/YefM, type II toxin-antitoxin system
PF07362 (HMM): post-segregation antitoxin CcdA
TIGR02384 (HMM): addiction module antitoxin, RelB/DinJ family
PF04221 (HMM): RelB antitoxin
PF03693 (HMM-CLUST): PF03693 family protein
PF01381 (HMM-CLUST): DNA-binding helix-turn-helix protein
TIGR02609 (HMM): putative addiction module antidote
TIGR02607 (HMM): addiction module antidote protein, HigA family
TIGR02606 (HMM): putative addiction module antidote protein, CC2985 family
TIGR01552 (HMM): prevent-host-death family protein
PF02604 (HMM): antitoxin Phd/YefM, type II toxin-antitoxin system
PF07362 (HMM): post-segregation antitoxin CcdA
TIGR02384 (HMM): addiction module antitoxin, RelB/DinJ family
PF04221 (HMM): RelB antitoxin
PF03693 (HMM-CLUST): PF03693 family protein
PF01381 (HMM-CLUST): DNA-binding helix-turn-helix protein
TIGR02609 (HMM): putative addiction module antidote
TIGR02607 (HMM): addiction module antidote protein, HigA family
TIGR02606 (HMM): putative addiction module antidote protein, CC2985 family
antidote partner (various)antidoteYESTIGR01552 (HMM): prevent-host-death family protein
PF02604 (HMM): antitoxin Phd/YefM, type II toxin-antitoxin system
PF07362 (HMM): post-segregation antitoxin CcdA
TIGR02384 (HMM): addiction module antitoxin, RelB/DinJ family
PF04221 (HMM): RelB antitoxin
PF03693 (HMM-CLUST): PF03693 family protein
PF01381 (HMM-CLUST): DNA-binding helix-turn-helix protein
TIGR02609 (HMM): putative addiction module antidote
TIGR02607 (HMM): addiction module antidote protein, HigA family
TIGR02606 (HMM): putative addiction module antidote protein, CC2985 family
TIGR01552 (HMM): prevent-host-death family protein
PF02604 (HMM): antitoxin Phd/YefM, type II toxin-antitoxin system
PF07362 (HMM): post-segregation antitoxin CcdA
TIGR02384 (HMM): addiction module antitoxin, RelB/DinJ family
PF04221 (HMM): RelB antitoxin
PF03693 (HMM-CLUST): PF03693 family protein
PF01381 (HMM-CLUST): DNA-binding helix-turn-helix protein
TIGR02609 (HMM): putative addiction module antidote
TIGR02607 (HMM): addiction module antidote protein, HigA family
TIGR02606 (HMM): putative addiction module antidote protein, CC2985 family
killing partnerkillingYESPF05016 (HMM): plasmid stabilization system protein, RelE/ParE family
TIGR02116 (HMM): addiction module toxin, Txe/YoeB family
TIGR02385 (HMM): addiction module toxin, RelE/StbE family
TIGR00053 (HMM): addiction module toxin component, YafQ family
PF01845 (HMM): CcdB protein
PF05012 (HMM):
PF05015 (HMM): plasmid maintenance system killer protein
TIGR01550 (HMM): death-on-curing family protein
PF03882 (HMM): KicB killing factor
PF08085 (HMM): entericidin EcnA/B family
PF02452 (HMM): PemK-like protein
TIGR00305 (HMM): putative toxin-antitoxin system toxin component, PIN family
PF05973 (HMM): Gp49-like PF05973 family
PF05016 (HMM): plasmid stabilization system protein, RelE/ParE family
TIGR02116 (HMM): addiction module toxin, Txe/YoeB family
TIGR02385 (HMM): addiction module toxin, RelE/StbE family
TIGR00053 (HMM): addiction module toxin component, YafQ family
PF01845 (HMM): CcdB protein
PF05012 (HMM):
PF05015 (HMM): plasmid maintenance system killer protein
TIGR01550 (HMM): death-on-curing family protein
PF03882 (HMM): KicB killing factor
PF08085 (HMM): entericidin EcnA/B family
PF02452 (HMM): PemK-like protein
TIGR00305 (HMM): putative toxin-antitoxin system toxin component, PIN family
PF05973 (HMM): Gp49-like PF05973 family
killing partnerkillingYESPF05016 (HMM): plasmid stabilization system protein, RelE/ParE family
TIGR02116 (HMM): addiction module toxin, Txe/YoeB family
TIGR02385 (HMM): addiction module toxin, RelE/StbE family
TIGR00053 (HMM): addiction module toxin component, YafQ family
PF01845 (HMM): CcdB protein
PF05012 (HMM):
PF05015 (HMM): plasmid maintenance system killer protein
TIGR01550 (HMM): death-on-curing family protein
PF03882 (HMM): KicB killing factor
PF08085 (HMM): entericidin EcnA/B family
PF02452 (HMM): PemK-like protein
TIGR00305 (HMM): putative toxin-antitoxin system toxin component, PIN family
PF05973 (HMM): Gp49-like PF05973 family
PF05016 (HMM): plasmid stabilization system protein, RelE/ParE family
TIGR02116 (HMM): addiction module toxin, Txe/YoeB family
TIGR02385 (HMM): addiction module toxin, RelE/StbE family
TIGR00053 (HMM): addiction module toxin component, YafQ family
PF01845 (HMM): CcdB protein
PF05012 (HMM):
PF05015 (HMM): plasmid maintenance system killer protein
TIGR01550 (HMM): death-on-curing family protein
PF03882 (HMM): KicB killing factor
PF08085 (HMM): entericidin EcnA/B family
PF02452 (HMM): PemK-like protein
TIGR00305 (HMM): putative toxin-antitoxin system toxin component, PIN family
PF05973 (HMM): Gp49-like PF05973 family
killing partnerkillingYESPF05016 (HMM): plasmid stabilization system protein, RelE/ParE family
TIGR02116 (HMM): addiction module toxin, Txe/YoeB family
TIGR02385 (HMM): addiction module toxin, RelE/StbE family
TIGR00053 (HMM): addiction module toxin component, YafQ family
PF01845 (HMM): CcdB protein
PF05012 (HMM):
PF05015 (HMM): plasmid maintenance system killer protein
TIGR01550 (HMM): death-on-curing family protein
PF03882 (HMM): KicB killing factor
PF08085 (HMM): entericidin EcnA/B family
PF02452 (HMM): PemK-like protein
TIGR00305 (HMM): putative toxin-antitoxin system toxin component, PIN family
PF05973 (HMM): Gp49-like PF05973 family
PF05016 (HMM): plasmid stabilization system protein, RelE/ParE family
TIGR02116 (HMM): addiction module toxin, Txe/YoeB family
TIGR02385 (HMM): addiction module toxin, RelE/StbE family
TIGR00053 (HMM): addiction module toxin component, YafQ family
PF01845 (HMM): CcdB protein
PF05012 (HMM):
PF05015 (HMM): plasmid maintenance system killer protein
TIGR01550 (HMM): death-on-curing family protein
PF03882 (HMM): KicB killing factor
PF08085 (HMM): entericidin EcnA/B family
PF02452 (HMM): PemK-like protein
TIGR00305 (HMM): putative toxin-antitoxin system toxin component, PIN family
PF05973 (HMM): Gp49-like PF05973 family
unassigned role in predicted moduleunassignNOTIGR02574 (HMM): putative addiction module component, TIGR02574 family
TIGR02574 (HMM): putative addiction module component, TIGR02574 family
unassigned role in predicted moduleunassignNOTIGR02574 (HMM): putative addiction module component, TIGR02574 family
TIGR02574 (HMM): putative addiction module component, TIGR02574 family
unassigned role in predicted moduleunassignNOTIGR02574 (HMM): putative addiction module component, TIGR02574 family
TIGR02574 (HMM): putative addiction module component, TIGR02574 family

Parent Properties
AccessionName
GenProp0066selfish genetic elements
GenProp0066selfish genetic elements
GenProp0066selfish genetic elements

Child Properties
AccessionName
GenProp0322addiction module, hig class
GenProp0323addiction module, ParE class
GenProp0324addiction module, RelE-RelB class
GenProp0453uncharacterized gene pair TIGR02612/TIGR02613
GenProp0322addiction module, hig class
GenProp0323addiction module, ParE class
GenProp0324addiction module, RelE-RelB class
GenProp0453uncharacterized gene pair TIGR02612/TIGR02613
GenProp0322addiction module, hig class
GenProp0323addiction module, ParE class
GenProp0324addiction module, RelE-RelB class
GenProp0453uncharacterized gene pair TIGR02612/TIGR02613

Sibling Properties
AccessionName
GenProp0009integrative genetic element
GenProp0010inteins
GenProp0024group I intron
GenProp0025group II intron
GenProp0050prophage regions
GenProp0208phage: major features
GenProp0226integron
GenProp0476protein-coding palindromic elements
GenProp1091toxin-antitoxin system, type I
GenProp1092toxin-antitoxin system, type III