Genome Property Definition Page

Nameaddiction module, RelE-RelB class
DescriptionToxin-antitoxin gene pairs, called addiction modules, are found often on plasmids but also on the chromosome. These modules can promote plasmid stability in populations by killing daughter cells that don't receive a copy of the plasmid during cell division. The phenomenon, called post-segregational killing, occurs because the antitoxin has a shorter biological half-life than the toxin. Some chromosomal toxin-antitoxin gene pairs appear to act in regulation of cellular processes and are not necessarily selfish genetic elements. The antitoxin generally is a transcription factor. The toxin may act in several ways This addiction module property describes the RelE system, where RelE acts by cleaving ribosome-associated transcripts.
JCVI RoleOther
Parent PropertyGenProp0321: toxin-antitoxin system, type II
Literature References
[ 1 ]Christensen SK, Mikkelsen M, Pedersen K, Gerdes K  RelE, a global inhibitor of translation, is activated during nutritional stress.  Proc Natl Acad Sci U S A 2001 Dec 4;98(25):14328-33. Epub 2001 Nov 20.  PMID 11717402

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
antidote RelB - PF04221A-RelBYESPF04221 (HMM): RelB antitoxin
TIGR01552 (HMM): prevent-host-death family protein
toxin RelE - TIGR02385K-RelEYESTIGR02385 (HMM): addiction module toxin, RelE/StbE family

Parent Properties
GenProp0321toxin-antitoxin system, type II

Sibling Properties
GenProp0322addiction module, hig class
GenProp0323addiction module, ParE class
GenProp0453uncharacterized gene pair TIGR02612/TIGR02613