Genome Property Definition Page
| Accession | GenProp0456 | |
| Name | attenuation system: tryptophanase | |
| Type | SYSTEM | |
| Description | This property is characterized by two components. One is the enzyme tryptophanase, capabable of degrading tryptophan. The other is the tryptophanase leader peptide, TnaC, encoded upstream of the enzyme. The ribosome that translates the leader peptide may stall at either of two points: the trp codon (when trp is scarce) or the stop codon. The leader peptide may interact with ribosome to delay release at its stop codon. Whether the ribosome stalls at the trp codon or continues to the stop codon controls what mRNA secondary structure may form as trytophanase message is synthesized. When trp is scarce, and the enzyme should not made, a terminator forms and transcription ends. Examples of this mechanism for controlling transcription at termination are called transcriptional attenuation. | |
| JCVI Role | Other | |
| Parent Property | GenProp0551: regulatory systems GenProp0734: amino acid catabolism | |
| Literature References |
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Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| tryptophanase TnaA | TnaA | YES | TIGR02617 (HMM): tryptophanase | |
| tryptophanase leader pep TnaC | leader | YES | TIGR02616 (HMM): tryptophanase leader peptide |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0551 | regulatory systems |
| GenProp0734 | amino acid catabolism |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0465 | circadian clock system KaiABC |
| GenProp0762 | chemotaxis response-regulator system |
| GenProp0849 | quorum-sensing, Bacillus PlcR-PapR system |
| GenProp0139 | degradation of tyrosine via homogentisate |
| GenProp0145 | histidine degradation to glutamate |
| GenProp0309 | arginine catabolism to glutamate via arginine succinyltransferase (AST) |
| GenProp0639 | arginine degradation via citrulline, ATP-generating |
| GenProp0659 | tryptophan degradation to anthranilate |