Genome Property Definition Page

AccessionGenProp0466
Namemolybdopterin biosynthesis
TypePATHWAY
DescriptionMolybdenum, in every enzyme containing it except nitrogenase, is a single atom coordinated by the two sulfur atoms of molybdopterin (MPT). MoaA and MoaC synthesize precursor Z from guanine. MoaD (supported by MoeB) and MoaE synthesize MPT from precursor Z. MoeA and MogA add molybdenum to the dithiolene of MPT. A molybdenum transport system (see GenProp0192) must also be present. In bacteria, MPT most often occurs as the derivative molybdopterin guanine dinucleotide (MGG); MobA catalyzes the addition of GMP to MPT. In hyperthermophiles, tungsten may substitute for molybdenum. In species with a member of family TIGR03309 (YqeB family), selenium can substitute for sulfur.
JCVI RoleMolybdopterin
Parent PropertyGenProp0184: cofactor biosynthesis
GenProp0184: cofactor biosynthesis
GenProp0184: cofactor biosynthesis
Literature References
[ 1 ]Nichols JD, Rajagopalan KV  In vitro molybdenum ligation to molybdopterin using purified components.  J Biol Chem 2005 Mar 4;280(9):7817-22. Epub 2005 Jan 4.  PMID 15632135
[ 1 ]Nichols JD, Rajagopalan KV  In vitro molybdenum ligation to molybdopterin using purified components.  J Biol Chem 2005 Mar 4;280(9):7817-22. Epub 2005 Jan 4.  PMID 15632135
[ 1 ]Nichols JD, Rajagopalan KV  In vitro molybdenum ligation to molybdopterin using purified components.  J Biol Chem 2005 Mar 4;280(9):7817-22. Epub 2005 Jan 4.  PMID 15632135
Gene Ontology TermGO:0032324: molybdopterin cofactor biosynthetic process (biological_process)
GO:0032324: molybdopterin cofactor biosynthetic process (biological_process)
GO:0032324: molybdopterin cofactor biosynthetic process (biological_process)
GO:0032324: molybdopterin cofactor biosynthetic process (biological_process)
GO:0032324: molybdopterin cofactor biosynthetic process (biological_process)
GO:0032324: molybdopterin cofactor biosynthetic process (biological_process)
GO:0032324: molybdopterin cofactor biosynthetic process (biological_process)
GO:0032324: molybdopterin cofactor biosynthetic process (biological_process)
GO:0032324: molybdopterin cofactor biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
molybdenum cofactor biosynthesis protein AmoaAYESTIGR02666 (HMM): molybdenum cofactor biosynthesis protein A
TIGR02668 (HMM): probable molybdenum cofactor biosynthesis protein A
GO:0032324: molybdopterin cofactor biosynthetic process
GO:0032324: molybdopterin cofactor biosynthetic process
molybdenum cofactor biosynthesis protein AmoaAYESTIGR02666 (HMM): molybdenum cofactor biosynthesis protein A
TIGR02668 (HMM): probable molybdenum cofactor biosynthesis protein A
GO:0032324: molybdopterin cofactor biosynthetic process
GO:0032324: molybdopterin cofactor biosynthetic process
molybdenum cofactor biosynthesis protein AmoaAYESTIGR02666 (HMM): molybdenum cofactor biosynthesis protein A
TIGR02668 (HMM): probable molybdenum cofactor biosynthesis protein A
GO:0032324: molybdopterin cofactor biosynthetic process
GO:0032324: molybdopterin cofactor biosynthetic process
molybdenum cofactor biosynthesis protein BmoaBNOTIGR02667 (HMM): molybdenum cofactor biosynthesis protein BGO:0032324: molybdopterin cofactor biosynthetic process
molybdenum cofactor biosynthesis protein BmoaBNOTIGR02667 (HMM): molybdenum cofactor biosynthesis protein BGO:0032324: molybdopterin cofactor biosynthetic process
molybdenum cofactor biosynthesis protein BmoaBNOTIGR02667 (HMM): molybdenum cofactor biosynthesis protein BGO:0032324: molybdopterin cofactor biosynthetic process
molybdenum cofactor biosynthesis protein CmoaCYESTIGR00581 (HMM): molybdenum cofactor biosynthesis protein CGO:0032324: molybdopterin cofactor biosynthetic process
molybdenum cofactor biosynthesis protein CmoaCYESTIGR00581 (HMM): molybdenum cofactor biosynthesis protein CGO:0032324: molybdopterin cofactor biosynthetic process
molybdenum cofactor biosynthesis protein CmoaCYESTIGR00581 (HMM): molybdenum cofactor biosynthesis protein CGO:0032324: molybdopterin cofactor biosynthetic process
molybdopterin converting factor, subunit 1moaDYESTIGR01682 (HMM): molybdopterin converting factor, subunit 1GO:0032324: molybdopterin cofactor biosynthetic process
molybdopterin converting factor, subunit 1moaDYESTIGR01682 (HMM): molybdopterin converting factor, subunit 1GO:0032324: molybdopterin cofactor biosynthetic process
molybdopterin converting factor, subunit 1moaDYESTIGR01682 (HMM): molybdopterin converting factor, subunit 1GO:0032324: molybdopterin cofactor biosynthetic process
molybdopterin converting factor, subunit 2moaEYESPF02391 (HMM): molybdopterin converting factor, subunit 2GO:0032324: molybdopterin cofactor biosynthetic process
molybdopterin converting factor, subunit 2moaEYESPF02391 (HMM): molybdopterin converting factor, subunit 2GO:0032324: molybdopterin cofactor biosynthetic process
molybdopterin converting factor, subunit 2moaEYESPF02391 (HMM): molybdopterin converting factor, subunit 2GO:0032324: molybdopterin cofactor biosynthetic process
molybdopterin-guanine dinucleotide biosynthesis protein AmobANOTIGR02665 (HMM): molybdenum cofactor guanylyltransferaseGO:0032324: molybdopterin cofactor biosynthetic process
molybdopterin-guanine dinucleotide biosynthesis protein AmobANOTIGR02665 (HMM): molybdenum cofactor guanylyltransferaseGO:0032324: molybdopterin cofactor biosynthetic process
molybdopterin-guanine dinucleotide biosynthesis protein AmobANOTIGR02665 (HMM): molybdenum cofactor guanylyltransferaseGO:0032324: molybdopterin cofactor biosynthetic process
molybdopterin-guanine dinucleotide biosynthesis protein BmobBYESTIGR00176 (HMM): molybdopterin-guanine dinucleotide biosynthesis protein BGO:0032324: molybdopterin cofactor biosynthetic process
molybdopterin-guanine dinucleotide biosynthesis protein BmobBYESTIGR00176 (HMM): molybdopterin-guanine dinucleotide biosynthesis protein BGO:0032324: molybdopterin cofactor biosynthetic process
molybdopterin-guanine dinucleotide biosynthesis protein BmobBYESTIGR00176 (HMM): molybdopterin-guanine dinucleotide biosynthesis protein BGO:0032324: molybdopterin cofactor biosynthetic process

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis
GenProp0184cofactor biosynthesis
GenProp0184cofactor biosynthesis


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis
GenProp1096coenzyme B biosynthesis