Genome Property Definition Page

AccessionGenProp0466
Namemolybdopterin biosynthesis
TypePATHWAY
DescriptionMolybdenum, in every enzyme containing it except nitrogenase, is a single atom coordinated by the two sulfur atoms of molybdopterin (MPT). MoaA and MoaC synthesize precursor Z from guanine. MoaD (supported by MoeB) and MoaE synthesize MPT from precursor Z. MoeA and MogA add molybdenum to the dithiolene of MPT. A molybdenum transport system (see GenProp0192) must also be present. In bacteria, MPT most often occurs as the derivative molybdopterin guanine dinucleotide (MGG); MobA catalyzes the addition of GMP to MPT. In hyperthermophiles, tungsten may substitute for molybdenum. In species with a member of family TIGR03309 (YqeB family), selenium can substitute for sulfur.
JCVI RoleMolybdopterin
Parent PropertyGenProp0184: cofactor biosynthesis
Literature References
[ 1 ]Nichols JD, Rajagopalan KV  In vitro molybdenum ligation to molybdopterin using purified components.  J Biol Chem 2005 Mar 4;280(9):7817-22. Epub 2005 Jan 4.  PMID 15632135
Gene Ontology TermGO:0032324: molybdopterin cofactor biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
molybdenum cofactor biosynthesis protein AmoaAYESTIGR02666 (HMM): molybdenum cofactor biosynthesis protein A
TIGR02668 (HMM): probable molybdenum cofactor biosynthesis protein A
GO:0032324: molybdopterin cofactor biosynthetic process
GO:0032324: molybdopterin cofactor biosynthetic process
molybdenum cofactor biosynthesis protein BmoaBNOTIGR02667 (HMM): molybdenum cofactor biosynthesis protein BGO:0032324: molybdopterin cofactor biosynthetic process
molybdenum cofactor biosynthesis protein CmoaCYESTIGR00581 (HMM): molybdenum cofactor biosynthesis protein CGO:0032324: molybdopterin cofactor biosynthetic process
molybdopterin converting factor, subunit 1moaDYESTIGR01682 (HMM): molybdopterin converting factor, subunit 1GO:0032324: molybdopterin cofactor biosynthetic process
molybdopterin converting factor, subunit 2moaEYESPF02391 (HMM): molybdopterin converting factor, subunit 2GO:0032324: molybdopterin cofactor biosynthetic process
molybdopterin-guanine dinucleotide biosynthesis protein AmobANOTIGR02665 (HMM): molybdenum cofactor guanylyltransferaseGO:0032324: molybdopterin cofactor biosynthetic process
molybdopterin-guanine dinucleotide biosynthesis protein BmobBYESTIGR00176 (HMM): molybdopterin-guanine dinucleotide biosynthesis protein BGO:0032324: molybdopterin cofactor biosynthetic process

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis