Genome Property Definition Page

Namearsenical resistance system
DescriptionA characteristic four-gene system for arsenic (and antimony) resistance is found in many prokaryotic genomes. The system includes a pump for extrusion of arsenite, an arsenate reductase that converts arsenate to arsenite for transport, a protein ArsH of unknown function that is sometimes not required, and a regulatory protein. Several distinct families are known for the arsenate reductase, ArsC, which may be dependent on glutaredoxin or thioredoxin in different instances.
JCVI RoleDetoxification
Parent PropertyGenProp0303: detoxification

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
arsenical resistance protein ArsHarsHYESTIGR02690 (HMM): arsenical resistance protein ArsH
arsenical resistance regulator ArsRarsRYESPF01022 (HMM-CLUST): transcriptional regulator, ArsR family
arsenite efflux transporter ArsBpumpYESTIGR00832 (HMM): arsenical-resistance protein
TIGR00935 (HMM): arsenite/antimonite efflux pump membrane protein
arsenate reductasereductYESTIGR02691 (HMM): arsenate reductase (thioredoxin)
TIGR02689 (HMM): arsenate reductase, glutathione/glutaredoxin type
TIGR00014 (HMM-CLUST): arsenate reductase (glutaredoxin)
PF01451 (HMM-CLUST): low molecular weight phosphotyrosine protein phosphatase

Parent Properties

Sibling Properties
GenProp0151resistance to mercury
GenProp0213Resistance to Reactive Oxygen Species (ROS)
GenProp0488superoxide dismutase, nickel-type
GenProp0562formaldehyde detoxification, glutathione-dependent
GenProp0673ribulose monophosphate pathway
GenProp0676alkylhydroperoxide reductase AhpCF (peroxiredoxin)
GenProp0744glyoxalase pathway, glutathione dependent