Genome Property Definition Page

AccessionGenProp0481
Nameurea carboxylase/allophanate hydrolase pathway
TypePATHWAY
DescriptionThis two-step, ATP-dependent pathway for urea hydrolysis is an alternative to urease. Urease requires a transporter and accessory proteins to produce its nickel metallocenter, while this two-step system uses biotin. Urea carboxylase acts first in this pathway, requiring ATP and bicarbonate as substrates. Allophanate hydrolase acts next, but note that this enzyme may be found in systems that do not contain a urea carboxylase. In yeasts such as Saccaromyces cerevisiae, the two activities of this pathway are encoded in a fusion protein, designated urea amidolyase. This pathway appears to function primarily for the purpose of obtaining nitrogen in the form of ammonia. A pair of uncharacterized, tandem, homologous genes, restricted to organisms with this system and adjacent to the known genes, has been added to this Genome Property.
JCVI RoleNitrogen metabolism
Parent PropertyGenProp0814: urea utilization
GenProp0814: urea utilization
GenProp0814: urea utilization
Literature References
[ 1 ]Kanamori T, Kanou N, Atomi H, Imanaka T  Enzymatic characterization of a prokaryotic urea carboxylase.  J Bacteriol 2004 May;186(9):2532-9.  PMID 15090492
[ 1 ]Kanamori T, Kanou N, Atomi H, Imanaka T  Enzymatic characterization of a prokaryotic urea carboxylase.  J Bacteriol 2004 May;186(9):2532-9.  PMID 15090492
[ 1 ]Kanamori T, Kanou N, Atomi H, Imanaka T  Enzymatic characterization of a prokaryotic urea carboxylase.  J Bacteriol 2004 May;186(9):2532-9.  PMID 15090492
Gene Ontology TermGO:0043419: urea catabolic process (biological_process)
GO:0043419: urea catabolic process (biological_process)
GO:0043419: urea catabolic process (biological_process)
GO:0043419: urea catabolic process (biological_process)
GO:0043419: urea catabolic process (biological_process)
GO:0043419: urea catabolic process (biological_process)
GO:0043419: urea catabolic process (biological_process)
GO:0043419: urea catabolic process (biological_process)
GO:0043419: urea catabolic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
ABC transporter periplasmic binding protein, urea carboxylase regionABC_binNOTIGR03427 (HMM): ABC transporter periplasmic binding protein, urea carboxylase region
TIGR03427 (HMM): ABC transporter periplasmic binding protein, urea carboxylase region
GO:0043419: urea catabolic process
GO:0043419: urea catabolic process
ABC transporter periplasmic binding protein, urea carboxylase regionABC_binNOTIGR03427 (HMM): ABC transporter periplasmic binding protein, urea carboxylase region
TIGR03427 (HMM): ABC transporter periplasmic binding protein, urea carboxylase region
GO:0043419: urea catabolic process
GO:0043419: urea catabolic process
ABC transporter periplasmic binding protein, urea carboxylase regionABC_binNOTIGR03427 (HMM): ABC transporter periplasmic binding protein, urea carboxylase region
TIGR03427 (HMM): ABC transporter periplasmic binding protein, urea carboxylase region
GO:0043419: urea catabolic process
GO:0043419: urea catabolic process
allophanate hydrolaseallophYESTIGR02713 (HMM): allophanate hydrolase
TIGR02713 (HMM): allophanate hydrolase
GO:0043419: urea catabolic process
GO:0043419: urea catabolic process
allophanate hydrolaseallophYESTIGR02713 (HMM): allophanate hydrolase
TIGR02713 (HMM): allophanate hydrolase
GO:0043419: urea catabolic process
GO:0043419: urea catabolic process
allophanate hydrolaseallophYESTIGR02713 (HMM): allophanate hydrolase
TIGR02713 (HMM): allophanate hydrolase
GO:0043419: urea catabolic process
GO:0043419: urea catabolic process
urea carboxylaseucaYESTIGR02712 (HMM): urea carboxylase
TIGR02712 (HMM): urea carboxylase
GO:0043419: urea catabolic process
GO:0043419: urea catabolic process
urea carboxylaseucaYESTIGR02712 (HMM): urea carboxylase
TIGR02712 (HMM): urea carboxylase
GO:0043419: urea catabolic process
GO:0043419: urea catabolic process
urea carboxylaseucaYESTIGR02712 (HMM): urea carboxylase
TIGR02712 (HMM): urea carboxylase
GO:0043419: urea catabolic process
GO:0043419: urea catabolic process
urea carboxylase-associated protein 1unchar1YESTIGR03424 (HMM): urea carboxylase-associated protein 1
TIGR03424 (HMM): urea carboxylase-associated protein 1
GO:0043419: urea catabolic process
GO:0043419: urea catabolic process
urea carboxylase-associated protein 1unchar1YESTIGR03424 (HMM): urea carboxylase-associated protein 1
TIGR03424 (HMM): urea carboxylase-associated protein 1
GO:0043419: urea catabolic process
GO:0043419: urea catabolic process
urea carboxylase-associated protein 1unchar1YESTIGR03424 (HMM): urea carboxylase-associated protein 1
TIGR03424 (HMM): urea carboxylase-associated protein 1
GO:0043419: urea catabolic process
GO:0043419: urea catabolic process
urea carboxylase-associated protein 2unchar2YESTIGR03425 (HMM): urea carboxylase-associated protein 2
TIGR03425 (HMM): urea carboxylase-associated protein 2
GO:0043419: urea catabolic process
GO:0043419: urea catabolic process
urea carboxylase-associated protein 2unchar2YESTIGR03425 (HMM): urea carboxylase-associated protein 2
TIGR03425 (HMM): urea carboxylase-associated protein 2
GO:0043419: urea catabolic process
GO:0043419: urea catabolic process
urea carboxylase-associated protein 2unchar2YESTIGR03425 (HMM): urea carboxylase-associated protein 2
TIGR03425 (HMM): urea carboxylase-associated protein 2
GO:0043419: urea catabolic process
GO:0043419: urea catabolic process

Parent Properties
AccessionName
GenProp0814urea utilization
GenProp0814urea utilization
GenProp0814urea utilization


Sibling Properties
AccessionName
GenProp0051urease
GenProp0743urea ABC transporter UrtABCDE